Hedgehog Signaling Overcomes an EZH2-Dependent Epigenetic Barrier to Promote Cholangiocyte Expansion

por Jalan-Sakrikar, Nidhi, De Assuncao, Thiago M., Lu, Jie, Almada, Luciana L., Lomberk, Gwen, Fernandez-Zapico, Martin E., Urrutia, Raul, Huebert, Robert C.
Publicado 2016

TFII-I-mediated polymerase pausing antagonizes GLI2 induction by TGFβ

por McCleary-Wheeler, Angela L, Paradise, Brooke D, Almada, Luciana L, Carlson, Annika J, Marks, David L, Vrabel, Anne, Vera, Renzo E, Sigafoos, Ashley N, Olson, Rachel L, Fernandez-Zapico, Martin E
Publicado 2020

ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL

por Pietrobono, Silvia, Anichini, Giulia, Sala, Cesare, Manetti, Fabrizio, Almada, Luciana L., Pepe, Sara, Carr, Ryan M., Paradise, Brooke D., Sarkaria, Jann N., Davila, Jaime I., Tofani, Lorenzo, Battisti, Ilaria, Arrigoni, Giorgio, Ying, Li, Zhang, Cheng, Li, Hu, Meves, Alexander, Fernandez-Zapico, Martin E., Stecca, Barbara
Publicado 2020

The Transcription Factor GLI1 Mediates TGFβ1 Driven EMT in Hepatocellular Carcinoma via a SNAI1-Dependent Mechanism

por Zheng, Xin, Rumie Vittar, Natalia B., Gai, Xiaohong, Fernandez-Barrena, Maite G., Moser, Catherine D., Hu, Chunling, Almada, Luciana L., McCleary-Wheeler, Angela L., Elsawa, Sherine F., Vrabel, Anne M., Shire, Abdirashid M., Comba, Andrea, Thorgeirsson, Snorri S., Kim, Youngsoo, Liu, Qingguang, Fernandez-Zapico, Martin E., Roberts, Lewis R.
Publicado 2012

A rare germline CDKN2A variant (47T>G; p16-L16R) predisposes carriers to pancreatic cancer by reducing cell cycle inhibition

por Horn, Isaac P., Marks, David L., Koenig, Amanda N., Hogenson, Tara L., Almada, Luciana L., Goldstein, Lauren E., Romecin Duran, Paola A., Vera, Renzo, Vrabel, Anne M., Cui, Gaofeng, Rabe, Kari G., Bamlet, William R., Mer, Georges, Sicotte, Hugues, Zhang, Cheng, Li, Hu, Petersen, Gloria M., Fernandez-Zapico, Martin E.
Publicado 2021

Ketogenic diets in healthy dogs induce gut and serum metabolome changes suggestive of anti‐tumourigenic effects: A model for human ketotherapy trials

por Allenspach, Karin, Borcherding, Dana C., Iennarella‐Servantez, Chelsea A., Mosichuk, Allison P., Atherly, Todd, Sahoo, Dipak Kumar, Kathrani, Aarti, Suchodolski, Jan S., Bourgois‐Mochel, Agnes, Serao, Mariana Rossoni, Serao, Nick V., Willette, Auriel, Perez, Beatriz Agulla, Gabriel, Vojtech, Mao, Sichao, Kilburn, Logan, Dang, Viet, Borts, David, Almada, Luciana L., Fernandez‐Zapico, Martin E., Phillips, Gregory J., Jergens, Albert E., Mochel, Jonathan P.
Publicado 2022

RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis

por Carr, Ryan M., Vorobyev, Denis, Lasho, Terra, Marks, David L., Tolosa, Ezequiel J., Vedder, Alexis, Almada, Luciana L., Yurcheko, Andrey, Padioleau, Ismael, Alver, Bonnie, Coltro, Giacomo, Binder, Moritz, Safgren, Stephanie L., Horn, Isaac, You, Xiaona, Solary, Eric, Balasis, Maria E., Berger, Kurt, Hiebert, James, Witzig, Thomas, Buradkar, Ajinkya, Graf, Temeida, Valent, Peter, Mangaonkar, Abhishek A., Robertson, Keith D., Howard, Matthew T., Kaufmann, Scott H., Pin, Christopher, Fernandez-Zapico, Martin E., Geissler, Klaus, Droin, Nathalie, Padron, Eric, Zhang, Jing, Nikolaev, Sergey, Patnaik, Mrinal M.
Publicado 2021

Culture media composition influences patient-derived organoid ability to predict therapeutic responses in gastrointestinal cancers

por Hogenson, Tara L., Xie, Hao, Phillips, William J., Toruner, Merih D., Li, Jenny J., Horn, Isaac P., Kennedy, Devin J., Almada, Luciana L., Marks, David L., Carr, Ryan M., Toruner, Murat, Sigafoos, Ashley N., Koenig-Kappes, Amanda N., Olson, Rachel L.O., Tolosa, Ezequiel J., Zhang, Cheng, Li, Hu, Doles, Jason D., Bleeker, Jonathan, Barrett, Michael T., Boyum, James H., Kipp, Benjamin R., Mahipal, Amit, Hubbard, Joleen M., Scheffler Hanson, Temperance J., Petersen, Gloria M., Dasari, Surendra, Oberg, Ann L., Truty, Mark J., Graham, Rondell P., Levy, Michael J., Zhu, Mojun, Billadeau, Daniel D., Adjei, Alex A., Dusetti, Nelson, Iovanna, Juan L., Bekaii-Saab, Tanios S., Ma, Wen Wee, Fernandez-Zapico, Martin E.
Publicado 2022

Molecular Modeling and Functional Analysis of Exome Sequencing–Derived Variants of Unknown Significance Identify a Novel, Constitutively Active FGFR2 Mutant in Cholangiocarcinoma

por Egan, Jan B., Marks, David L., Hogenson, Tara L., Vrabel, Anne M., Sigafoos, Ashley N., Tolosa, Ezequiel J., Carr, Ryan M., Safgren, Stephanie L., Enriquez Hesles, Elisa, Almada, Luciana L., Romecin-Duran, Paola A., Iguchi, Eriko, Ala’Aldeen, Aryan, Kocher, Jean-Pierre A., Oliver, Gavin R., Prodduturi, Naresh, Mead, David W., Hossain, Asif, Huneke, Norine E., Tagtow, Colleen M., Ailawadhi, Sikander, Ansell, Stephen M., Banck, Michaela S., Bryce, Alan H., Carballido, Estrella M., Chanan-Khan, Asher A., Curtis, Kelly K., Resnik, Ernesto, Gawryletz, Chelsea D., Go, Ronald S., Halfdanarson, Thorvardur R., Ho, Thai H., Joseph, Richard W., Kapoor, Prashant, Mansfield, Aaron S., Meurice, Nathalie, Nageswara Rao, Amulya A., Nowakowski, Grzegorz S., Pardanani, Animesh, Parikh, Sameer A., Cheville, John C., Feldman, Andrew L., Ramanathan, Ramesh K., Robinson, Steven I., Tibes, Raoul, Finnes, Heidi D., McCormick, Jennifer B., McWilliams, Robert R., Jatoi, Aminah, Patnaik, Mrinal M., Silva, Alvin C., Wieben, Eric D., McAllister, Tammy M., Rumilla, Kandelaria M., Kerr, Sarah E., Lazaridis, Konstantinos N., Farrugia, Gianrico, Stewart, A. Keith, Clark, Karl J., Kennedy, Eileen J., Klee, Eric W., Borad, Mitesh J., Fernandez-Zapico, Martin E.
Publicado 2017