Iminosugar antivirals: the therapeutic sweet spot

por Alonzi, Dominic S., Scott, Kathryn A., Dwek, Raymond A., Zitzmann, Nicole
Publicado 2017

Antiviral effects of deoxynojirimycin (DNJ)-based iminosugars in dengue virus-infected primary dendritic cells

por Perera, Nilanka, Brun, Juliane, Alonzi, Dominic S., Tyrrell, Beatrice E., Miller, Joanna L., Zitzmann, Nicole
Publicado 2022

Amine-linked diglycosides: Synthesis facilitated by the enhanced reactivity of allylic electrophiles, and glycosidase inhibition assays

por Cumpstey, Ian, Frigell, Jens, Pershagen, Elias, Akhtar, Tashfeen, Moreno-Clavijo, Elena, Robina, Inmaculada, Alonzi, Dominic S, Butters, Terry D
Publicado 2011

ToP-DNJ, a Selective Inhibitor of Endoplasmic Reticulum α-Glucosidase II Exhibiting Antiflaviviral Activity

por Kiappes, J. L., Hill, Michelle L., Alonzi, Dominic S., Miller, Joanna L., Iwaki, Ren, Sayce, Andrew C., Caputo, Alessandro T., Kato, Atsushi, Zitzmann, Nicole
Publicado 2017

Engineering Hydrophobic Protein–Carbohydrate Interactions to Fine-Tune Monoclonal Antibodies

por Yu, Xiaojie, Baruah, Kavitha, Harvey, David J., Vasiljevic, Snezana, Alonzi, Dominic S., Song, Byeong-Doo, Higgins, Matthew K., Bowden, Thomas A., Scanlan, Christopher N., Crispin, Max
Publicado 2013

Exploring the Potential of Iminosugars as Antivirals for Crimean-Congo Haemorrhagic Fever Virus, Using the Surrogate Hazara Virus: Liquid-Chromatography-Based Mapping of Viral N-Gl...

por Tyrrell, Beatrice E., Kumar, Abhinav, Gangadharan, Bevin, Alonzi, Dominic, Brun, Juliane, Hill, Michelle, Bharucha, Tehmina, Bosworth, Andrew, Graham, Victoria, Dowall, Stuart, Miller, Joanna L., Zitzmann, Nicole
Publicado 2023

A Novel Iminosugar UV-12 with Activity against the Diverse Viruses Influenza and Dengue (Novel Iminosugar Antiviral for Influenza and Dengue)

por Warfield, Kelly L., Plummer, Emily, Alonzi, Dominic S., Wolfe, Gary W., Sampath, Aruna, Nguyen, Tam, Butters, Terry D., Enterlein, Sven G., Stavale, Eric J., Shresta, Sujan, Ramstedt, Urban
Publicado 2015

Assessing Antigen Structural Integrity through Glycosylation Analysis of the SARS-CoV-2 Viral Spike

por Brun, Juliane, Vasiljevic, Snežana, Gangadharan, Bevin, Hensen, Mario, V. Chandran, Anu, Hill, Michelle L., Kiappes, J.L., Dwek, Raymond A., Alonzi, Dominic S., Struwe, Weston B., Zitzmann, Nicole
Publicado 2021

Structure of human endo-α-1,2-mannosidase (MANEA), an antiviral host-glycosylation target

por Sobala, Łukasz F., Fernandes, Pearl Z., Hakki, Zalihe, Thompson, Andrew J., Howe, Jonathon D., Hill, Michelle, Zitzmann, Nicole, Davies, Scott, Stamataki, Zania, Butters, Terry D., Alonzi, Dominic S., Williams, Spencer J., Davies, Gideon J.
Publicado 2020

Minimal In Vivo Efficacy of Iminosugars in a Lethal Ebola Virus Guinea Pig Model

por Miller, Joanna L., Spiro, Simon G., Dowall, Stuart D., Taylor, Irene, Rule, Antony, Alonzi, Dominic S., Sayce, Andrew C., Wright, Edward, Bentley, Emma M., Thom, Ruth, Hall, Graham, Dwek, Raymond A., Hewson, Roger, Zitzmann, Nicole
Publicado 2016

Iminosugars Inhibit Dengue Virus Production via Inhibition of ER Alpha-Glucosidases—Not Glycolipid Processing Enzymes

por Sayce, Andrew C., Alonzi, Dominic S., Killingbeck, Sarah S., Tyrrell, Beatrice E., Hill, Michelle L., Caputo, Alessandro T., Iwaki, Ren, Kinami, Kyoko, Ide, Daisuke, Kiappes, J. L., Beatty, P. Robert, Kato, Atsushi, Harris, Eva, Dwek, Raymond A., Miller, Joanna L., Zitzmann, Nicole
Publicado 2016

Hepatitis C virus E2 envelope glycoprotein produced in Nicotiana benthamiana triggers humoral response with virus‐neutralizing activity in vaccinated mice

por Dobrica, Mihaela‐Olivia, van Eerde, André, Tucureanu, Catalin, Onu, Adrian, Paruch, Lisa, Caras, Iuliana, Vlase, Ene, Steen, Hege, Haugslien, Sissel, Alonzi, Dominic, Zitzmann, Nicole, Bock, Ralph, Dubuisson, Jean, Popescu, Costin‐Ioan, Stavaru, Crina, Liu Clarke, Jihong, Branza‐Nichita, Norica
Publicado 2021

Clamping, bending, and twisting inter-domain motions in the misfold-recognizing portion of UDP-glucose: Glycoprotein glucosyltransferase

por Modenutti, Carlos P., Blanco Capurro, Juan I., Ibba, Roberta, Alonzi, Dominic S., Song, Mauro N., Vasiljević, Snežana, Kumar, Abhinav, Chandran, Anu V., Tax, Gabor, Marti, Lucia, Hill, Johan C., Lia, Andrea, Hensen, Mario, Waksman, Thomas, Rushton, Jonathan, Rubichi, Simone, Santino, Angelo, Martí, Marcelo A., Zitzmann, Nicole, Roversi, Pietro
Publicado 2021

Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4

por Warfield, Kelly L., Plummer, Emily M., Sayce, Andrew C., Alonzi, Dominic S., Tang, William, Tyrrell, Beatrice E., Hill, Michelle L., Caputo, Alessandro T., Killingbeck, Sarah S., Beatty, P. Robert, Harris, Eva, Iwaki, Ren, Kinami, Kyoko, Ide, Daisuke, Kiappes, J.L., Kato, Atsushi, Buck, Michael D., King, Kevin, Eddy, William, Khaliq, Mansoora, Sampath, Aruna, Treston, Anthony M., Dwek, Raymond A., Enterlein, Sven G., Miller, Joanna L., Zitzmann, Nicole, Ramstedt, Urban, Shresta, Sujan
Publicado 2016