High-resolution complex of papain with remnants of a cysteine protease inhibitor derived from Trypanosoma brucei

por Alphey, Magnus S., Hunter, William N.
Publicado 2006

Structural and mechanistic insights into type II trypanosomatid tryparedoxin-dependent peroxidases

por Alphey, Magnus S., König, Janine, Fairlamb, Alan H.
Publicado 2008

Non‐canonical binding of the Chaetomium thermophilum PolD4 N‐terminal PIP motif to PCNA involves Q‐pocket and compact 2‐fork plug interactions but no 3(10) helix

por Yang, Dongxiao, Alphey, Magnus S., MacNeill, Stuart A.
Publicado 2022

Structure of Trypanosoma brucei glutathione synthetase: Domain and loop alterations in the catalytic cycle of a highly conserved enzyme

por Fyfe, Paul K., Alphey, Magnus S., Hunter, William N.
Publicado 2010

Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome

por Jones, Deuan C, Alphey, Magnus S, Wyllie, Susan, Fairlamb, Alan H
Publicado 2012

Mapping the Structural Path for Allosteric Inhibition of a Short-Form ATP Phosphoribosyltransferase by Histidine

por Thomson, Catherine M., Alphey, Magnus S., Fisher, Gemma, da Silva, Rafael G.
Publicado 2019

Trypanosoma brucei UDP-galactose-4′-epimerase in ternary complex with NAD(+) and the substrate analogue UDP-4-deoxy-4-fluoro-α-d-galactose

por Alphey, Magnus S., Burton, Andrew, Urbaniak, Michael D., Boons, Geert-Jan, Ferguson, Michael A. J., Hunter, William N.
Publicado 2006

Allosteric rescue of catalytically impaired ATP phosphoribosyltransferase variants links protein dynamics to active-site electrostatic preorganisation

por Fisher, Gemma, Corbella, Marina, Alphey, Magnus S., Nicholson, John, Read, Benjamin J., Kamerlin, Shina C. L., da Silva, Rafael G.
Publicado 2022

The Synthesis of UDP-N-acetylglucosamine Is Essential for Bloodstream Form Trypanosoma brucei in Vitro and in Vivo and UDP-N-acetylglucosamine Starvation Reveals a Hierarchy in P...

por Stokes, Matthew J., Güther, M. Lucia S., Turnock, Daniel C., Prescott, Alan R., Martin, Kirstee L., Alphey, Magnus S., Ferguson, Michael A. J.
Publicado 2008

Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallo...

por Patterson, Stephen, Alphey, Magnus S., Jones, Deuan C., Shanks, Emma J., Street, Ian P., Frearson, Julie A., Wyatt, Paul G., Gilbert, Ian H., Fairlamb, Alan H.
Publicado 2011

Next generation Glucose-1-phosphate thymidylyltransferase (RmlA) inhibitors: An extended SAR study to direct future design

por Xiao, Ganyuan, Alphey, Magnus S., Tran, Fanny, Pirrie, Lisa, Milbeo, Pierre, Zhou, Yi, Bickel, Jasmine K., Kempf, Oxana, Kempf, Karl, Naismith, James H., Westwood, Nicholas J.
Publicado 2021

Characterization of Aquifex aeolicus 4-diphosphocytidyl-2C-methyl-d-erythritol kinase – ligand recognition in a template for antimicrobial drug discovery

por Sgraja, Tanja, Alphey, Magnus S, Ghilagaber, Stephanos, Marquez, Rudi, Robertson, Murray N, Hemmings, Jennifer L, Lauw, Susan, Rohdich, Felix, Bacher, Adelbert, Eisenreich, Wolfgang, Illarionova, Victoria, Hunter, William N
Publicado 2008

The AEROPATH project targeting Pseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery

por Moynie, Lucille, Schnell, Robert, McMahon, Stephen A., Sandalova, Tatyana, Boulkerou, Wassila Abdelli, Schmidberger, Jason W., Alphey, Magnus, Cukier, Cyprian, Duthie, Fraser, Kopec, Jolanta, Liu, Huanting, Jacewicz, Agata, Hunter, William N., Naismith, James H., Schneider, Gunter
Publicado 2012