MYCN-mediated murine cancer models

por Althoff, Kristina, Schramm, Alexander
Publicado 2017

Covalent‐Allosteric Inhibitors to Achieve Akt Isoform‐Selectivity

por Quambusch, Lena, Landel, Ina, Depta, Laura, Weisner, Jörn, Uhlenbrock, Niklas, Müller, Matthias P., Glanemann, Franziska, Althoff, Kristina, Siveke, Jens T., Rauh, Daniel
Publicado 2019

Druggable epigenetic suppression of interferon-induced chemokine expression linked to MYCN amplification in neuroblastoma

por Seier, Johanna A, Reinhardt, Julia, Saraf, Kritika, Ng, Susanna S, Layer, Julian P, Corvino, Dillon, Althoff, Kristina, Giordano, Frank A, Schramm, Alexander, Fischer, Matthias, Hölzel, Michael
Publicado 2021

RITA displays anti-tumor activity in medulloblastomas independent of TP53 status

por Gottlieb, Aline, Althoff, Kristina, Grunewald, Laura, Thor, Theresa, Odersky, Andrea, Schulte, Marc, Deubzer, Hedwig E., Heukamp, Lukas, Eggert, Angelika, Schramm, Alexander, Schulte, Johannes H., Künkele, Annette
Publicado 2017

BET bromodomain protein inhibition is a therapeutic option for medulloblastoma

por Henssen, Anton, Thor, Theresa, Odersky, Andrea, Heukamp, Lukas, El-Hindy, Nicolai, Beckers, Anneleen, Speleman, Frank, Althoff, Kristina, Schäfers, Simon, Schramm, Alexander, Sure, Ulrich, Fleischhack, Gudrun, Eggert, Angelika, Schulte, Johannes H.
Publicado 2013

MYCN-targeting miRNAs are predominantly downregulated during MYCN-driven neuroblastoma tumor formation

por Beckers, Anneleen, Van Peer, Gert, Carter, Daniel R., Mets, Evelien, Althoff, Kristina, Cheung, Belamy B., Schulte, Johannes H., Mestdagh, Pieter, Vandesompele, Jo, Marshall, Glenn M., De Preter, Katleen, Speleman, Frank
Publicado 2014

Targeting tachykinin receptors in neuroblastoma

por Henssen, Anton G., Odersky, Andrea, Szymansky, Annabell, Seiler, Marleen, Althoff, Kristina, Beckers, Anneleen, Speleman, Frank, Schäfers, Simon, De Preter, Katleen, Astrahanseff, Kathy, Struck, Joachim, Schramm, Alexander, Eggert, Angelika, Bergmann, Andreas, Schulte, Johannes H.
Publicado 2016

Cellular model system to dissect the isoform-selectivity of Akt inhibitors

por Quambusch, Lena, Depta, Laura, Landel, Ina, Lubeck, Melissa, Kirschner, Tonia, Nabert, Jonas, Uhlenbrock, Niklas, Weisner, Jörn, Kostka, Michael, Levy, Laura M., Schultz-Fademrecht, Carsten, Glanemann, Franziska, Althoff, Kristina, Müller, Matthias P., Siveke, Jens T., Rauh, Daniel
Publicado 2021

Characterization of pancreatic glucagon-producing tumors and pituitary gland tumors in transgenic mice overexpressing MYCN in hGFAP-positive cells

por Fielitz, Kathrin, Althoff, Kristina, De Preter, Katleen, Nonnekens, Julie, Ohli, Jasmin, Elges, Sandra, Hartmann, Wolfgang, Klöppel, Günter, Knösel, Thomas, Schulte, Marc, Klein-Hitpass, Ludger, Beisser, Daniela, Reis, Henning, Eyking, Annette, Cario, Elke, Schulte, Johannes H., Schramm, Alexander, Schüller, Ulrich
Publicado 2016

The GSK461364 PLK1 inhibitor exhibits strong antitumoral activity in preclinical neuroblastoma models

por Pajtler, Kristian W, Sadowski, Natalie, Ackermann, Sandra, Althoff, Kristina, Schönbeck, Kerstin, Batzke, Katharina, Sch, Simonäfers, Odersky, Andrea, Heukamp, Lukas, Astrahantseff, Kathy, Künkele, Annette, Deubzer, Hedwig E, Schramm, Alexander, Spr, Annikaüssel, Thor, Theresa, Lindner, Sven, Eggert, Angelika, Fischer, Matthias, Schulte, Johannes H
Publicado 2016

MYCN transcriptionally represses CD9 to trigger an invasion-metastasis cascade in neuroblastoma

por Fabian, Johannes, Opitz, Desirée, Althoff, Kristina, Lodrini, Marco, Astrahantseff, Kathy, Hero, Barbara, Volland, Ruth, Beckers, Anneleen, Preter, Katleen de, Patil, Nitin S, Abba, Mohammed L, Thole, Theresa M, Wünschel, Jasmin, Künkele, Annette, Hu, Jamie, Schweizer, Leonille, Mechtersheimer, Gunhild, Carter, Daniel R, Cheung, Belamy B, Popanda, Odilia, Deimling, Andreas von, Henrich, Kai-Oliver, Westermann, Frank, Schwab, Manfred, Koster, Jan, Versteeg, Rogier, Marshall, Glenn M, Speleman, Frank, Zoeller, Margot, Allgayer, Heike, Fischer, Matthias, Berthold, Frank, Kulozik, Andreas E, Witt, Olaf, Eggert, Angelika, Schulte, Johannes H, Deubzer, Hedwig E
Publicado 2015

MYCN and HDAC5 transcriptionally repress CD9 to trigger invasion and metastasis in neuroblastoma

por Fabian, Johannes, Opitz, Desirée, Althoff, Kristina, Lodrini, Marco, Hero, Barbara, Volland, Ruth, Beckers, Anneleen, de Preter, Katleen, Decock, Anneleen, Patil, Nitin, Abba, Mohammed, Kopp-Schneider, Annette, Astrahantseff, Kathy, Wünschel, Jasmin, Pfeil, Sebastian, Ercu, Maria, Künkele, Annette, Hu, Jamie, Thole, Theresa, Schweizer, Leonille, Mechtersheimer, Gunhild, Carter, Daniel, Cheung, Belamy B., Popanda, Odilia, von Deimling, Andreas, Koster, Jan, Versteeg, Rogier, Schwab, Manfred, Marshall, Glenn M., Speleman, Frank, Erb, Ulrike, Zoeller, Margot, Allgayer, Heike, Simon, Thorsten, Fischer, Matthias, Kulozik, Andreas E., Eggert, Angelika, Witt, Olaf, Schulte, Johannes H., Deubzer, Hedwig E.
Publicado 2016

Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression

por Cheung, Phyllis F., Yang, JiaJin, Fang, Rui, Borgers, Arianna, Krengel, Kirsten, Stoffel, Anne, Althoff, Kristina, Yip, Chi Wai, Siu, Elaine H. L., Ng, Linda W. C., Lang, Karl S., Cham, Lamin B., Engel, Daniel R., Soun, Camille, Cima, Igor, Scheffler, Björn, Striefler, Jana K., Sinn, Marianne, Bahra, Marcus, Pelzer, Uwe, Oettle, Helmut, Markus, Peter, Smeets, Esther M. M., Aarntzen, Erik H. J. G., Savvatakis, Konstantinos, Liffers, Sven-Thorsten, Lueong, Smiths S., Neander, Christian, Bazarna, Anna, Zhang, Xin, Paschen, Annette, Crawford, Howard C., Chan, Anthony W. H., Cheung, Siu Tim, Siveke, Jens T.
Publicado 2022