The chemistry and biology of mycolactones

por Gehringer, Matthias, Altmann, Karl-Heinz
Publicado 2017

Ring-Closing Metathesis Approaches towards the Total Synthesis of Rhizoxins

por Liniger, Marc, Neuhaus, Christian M., Altmann, Karl-Heinz
Publicado 2020

Synthesis and Biological Evaluation of C(13)/C(13′)‐Bis(desmethyl)disorazole Z

por Bold, Christian Paul, Lucena‐Agell, Daniel, Oliva, María Ángela, Díaz, José Fernando, Altmann, Karl‐Heinz
Publicado 2022

Structure-Activity Relationship Studies on the Macrolide Exotoxin Mycolactone of Mycobacterium ulcerans

por Scherr, Nicole, Gersbach, Philipp, Dangy, Jean-Pierre, Bomio, Claudio, Li, Jun, Altmann, Karl-Heinz, Pluschke, Gerd
Publicado 2013

Zampanolide, a Microtubule-Stabilizing Agent, Is Active in Resistant Cancer Cells and Inhibits Cell Migration

por Field, Jessica J., Northcote, Peter T., Paterson, Ian, Altmann, Karl-Heinz, Díaz, J. Fernando, Miller, John H.
Publicado 2017

Synthesis, Microtubule-Binding Affinity, and Antiproliferative Activity of New Epothilone Analogs and of an EGFR-Targeted Epothilone-Peptide Conjugate

por Gaugaz, Fabienne Zdenka, Chicca, Andrea, Redondo-Horcajo, Mariano, Barasoain, Isabel, Díaz, J. Fernando, Altmann, Karl-Heinz
Publicado 2019

The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model

por Häfliger, Pascal, Graff, Julien, Rubin, Matthias, Stooss, Amandine, Dettmer, Matthias S., Altmann, Karl-Heinz, Gertsch, Jürg, Charles, Roch-Philippe
Publicado 2018

Development of an ELISA for the quantification of mycolactone, the cytotoxic macrolide toxin of Mycobacterium ulcerans

por Warryn, Louisa, Dangy, Jean-Pierre, Gersbach, Philipp, Gehringer, Matthias, Schäfer, Anja, Ruf, Marie-Thérèse, Ruggli, Nicolas, Altmann, Karl-Heinz, Pluschke, Gerd
Publicado 2020

Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter

por Yan, Renhong, Li, Yaning, Müller, Jennifer, Zhang, Yuanyuan, Singer, Simon, Xia, Lu, Zhong, Xinyue, Gertsch, Jürg, Altmann, Karl-Heinz, Zhou, Qiang
Publicado 2021

Synthesis, Biological Profiling and Determination of the Tubulin-Bound Conformation of 12-Aza-Epothilones (Azathilones)

por Jantsch, Andrea, Nieto, Lidia, Gertsch, Jürg, Rodríguez-Salarichs, Javier, Matesanz, Ruth, Jiménez-Barbero, Jesús, Díaz, J. Fernando, Canales, Ángeles, Altmann, Karl-Heinz
Publicado 2016

Towards a new tuberculosis drug: pyridomycin – nature's isoniazid

por Hartkoorn, Ruben C, Sala, Claudia, Neres, João, Pojer, Florence, Magnet, Sophie, Mukherjee, Raju, Uplekar, Swapna, Boy-Röttger, Stefanie, Altmann, Karl-Heinz, Cole, Stewart T
Publicado 2012

Antibody-Mediated Neutralization of the Exotoxin Mycolactone, the Main Virulence Factor Produced by Mycobacterium ulcerans

por Dangy, Jean-Pierre, Scherr, Nicole, Gersbach, Philipp, Hug, Melanie N., Bieri, Raphael, Bomio, Claudio, Li, Jun, Huber, Sylwia, Altmann, Karl-Heinz, Pluschke, Gerd
Publicado 2016

The Evaluation of l‐Tryptophan Derivatives as Inhibitors of the l‐Type Amino Acid Transporter LAT1 (SLC7A5)

por Graff, Julien, Müller, Jennifer, Sadurní, Anna, Rubin, Matthias, Canivete Cuissa, Inês André, Keller, Claudia, Hartmann, Marco, Singer, Simon, Gertsch, Jürg, Altmann, Karl‐Heinz
Publicado 2022

Small molecule inhibitors provide insights into the relevance of LAT1 and LAT2 in materno‐foetal amino acid transport

por Zaugg, Jonas, Huang, Xiao, Ziegler, Fabian, Rubin, Matthias, Graff, Julien, Müller, Jennifer, Moser‐Hässig, Ruedi, Powell, Theresa, Gertsch, Jürg, Altmann, Karl‐Heinz, Albrecht, Christiane
Publicado 2020

Morphing of Amphipathic Helices to Explore the Activity and Selectivity of Membranolytic Antimicrobial Peptides

por Müller, Alex T., Posselt, Gernot, Gabernet, Gisela, Neuhaus, Claudia, Bachler, Simon, Blatter, Markus, Pfeiffer, Bernhard, Hiss, Jan A., Dittrich, Petra S., Altmann, Karl-Heinz, Wessler, Silja, Schneider, Gisbert
Publicado 2020

A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin

por Menchon, Grégory, Prota, Andrea E., Lucena-Agell, Daniel, Bucher, Pascal, Jansen, Rolf, Irschik, Herbert, Müller, Rolf, Paterson, Ian, Díaz, J. Fernando, Altmann, Karl-Heinz, Steinmetz, Michel O.
Publicado 2018

Arylvinylpiperazine Amides, a New Class of Potent Inhibitors Targeting QcrB of Mycobacterium tuberculosis

por Foo, Caroline S., Lupien, Andréanne, Kienle, Maryline, Vocat, Anthony, Benjak, Andrej, Sommer, Raphael, Lamprecht, Dirk A., Steyn, Adrie J. C., Pethe, Kevin, Piton, Jérémie, Altmann, Karl-Heinz, Cole, Stewart T.
Publicado 2018

Maytansinol Derivatives: Side Reactions as a Chance for New Tubulin Binders

por Marzullo, Paola, Boiarska, Zlata, Pérez‐Peña, Helena, Abel, Anne‐Catherine, Álvarez‐Bernad, Beatriz, Lucena‐Agell, Daniel, Vasile, Francesca, Sironi, Maurizio, Altmann, Karl‐Heinz, Prota, Andrea E., Díaz, J. Fernando, Pieraccini, Stefano, Passarella, Daniele
Publicado 2021

Structural insight into the stabilization of microtubules by taxanes

por Prota, Andrea E, Lucena-Agell, Daniel, Ma, Yuntao, Estevez-Gallego, Juan, Li, Shuo, Bargsten, Katja, Josa-Prado, Fernando, Altmann, Karl-Heinz, Gaillard, Natacha, Kamimura, Shinji, Mühlethaler, Tobias, Gago, Federico, Oliva, Maria A, Steinmetz, Michel O, Fang, Wei-Shuo, Díaz, J Fernando
Publicado 2023

Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands

por Balaguer, Francisco de Asís, Mühlethaler, Tobias, Estévez-Gallego, Juan, Calvo, Enrique, Giménez-Abián, Juan Francisco, Risinger, April L., Sorensen, Erik J., Vanderwal, Christopher D., Altmann, Karl-Heinz, Mooberry, Susan L., Steinmetz, Michel O., Oliva, María Ángela, Prota, Andrea E., Díaz, J. Fernando
Publicado 2019