N-Glycans and Glycosylphosphatidylinositol-Anchor Act on Polarized Sorting of Mouse PrP(C) in Madin-Darby Canine Kidney Cells

por Puig, Berta, Altmeppen, Hermann C., Thurm, Dana, Geissen, Markus, Conrad, Catharina, Braulke, Thomas, Glatzel, Markus
Publicado 2011

Inducing prion protein shedding as a neuroprotective and regenerative approach in pathological conditions of the brain: from theory to facts

por Matamoros-Angles, Andreu, Mohammadi, Behnam, Song, Feizhi, Shafiq, Mohsin, Brenna, Santra, Puig, Berta, Glatzel, Markus, Altmeppen, Hermann C.
Publicado 2023

α-Synuclein conformers reveal link to clinical heterogeneity of α-synucleinopathies

por Schmitz, Matthias, Candelise, Niccolò, Canaslan, Sezgi, Altmeppen, Hermann C., Matschke, Jakob, Glatzel, Markus, Younas, Neelam, Zafar, Saima, Hermann, Peter, Zerr, Inga
Publicado 2023

GPI-anchor signal sequence influences PrP(C) sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice

por Puig, Berta, Altmeppen, Hermann C., Linsenmeier, Luise, Chakroun, Karima, Wegwitz, Florian, Piontek, Ulrike K., Tatzelt, Jörg, Bate, Clive, Magnus, Tim, Glatzel, Markus
Publicado 2019

Secretory pathway retention of mutant prion protein induces p38-MAPK activation and lethal disease in mice

por Puig, Berta, Altmeppen, Hermann C., Ulbrich, Sarah, Linsenmeier, Luise, Krasemann, Susanne, Chakroun, Karima, Acevedo-Morantes, Claudia Y., Wille, Holger, Tatzelt, Jörg, Glatzel, Markus
Publicado 2016

Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo

por Altmeppen, Hermann C, Prox, Johannes, Puig, Berta, Kluth, Mark A, Bernreuther, Christian, Thurm, Dana, Jorissen, Ellen, Petrowitz, Bettina, Bartsch, Udo, De Strooper, Bart, Saftig, Paul, Glatzel, Markus
Publicado 2011

Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein

por Linsenmeier, Luise, Mohammadi, Behnam, Wetzel, Sebastian, Puig, Berta, Jackson, Walker S., Hartmann, Alexander, Uchiyama, Keiji, Sakaguchi, Suehiro, Endres, Kristina, Tatzelt, Jörg, Saftig, Paul, Glatzel, Markus, Altmeppen, Hermann C.
Publicado 2018

Characterization of brain-derived extracellular vesicles reveals changes in cellular origin after stroke and enrichment of the prion protein with a potential role in cellular uptak...

por Brenna, Santra, Altmeppen, Hermann C., Mohammadi, Behnam, Rissiek, Björn, Schlink, Florence, Ludewig, Peter, Krisp, Christoph, Schlüter, Hartmut, Failla, Antonio Virgilio, Schneider, Carola, Glatzel, Markus, Puig, Berta, Magnus, Tim
Publicado 2020

Transgenic Overexpression of the Disordered Prion Protein N1 Fragment in Mice Does Not Protect Against Neurodegenerative Diseases Due to Impaired ER Translocation

por Mohammadi, Behnam, Linsenmeier, Luise, Shafiq, Mohsin, Puig, Berta, Galliciotti, Giovanna, Giudici, Camilla, Willem, Michael, Eden, Thomas, Koch-Nolte, Friedrich, Lin, Yu-Hsuan, Tatzelt, Jörg, Glatzel, Markus, Altmeppen, Hermann C.
Publicado 2020

The sheddase ADAM10 is a potent modulator of prion disease

por Altmeppen, Hermann C, Prox, Johannes, Krasemann, Susanne, Puig, Berta, Kruszewski, Katharina, Dohler, Frank, Bernreuther, Christian, Hoxha, Ana, Linsenmeier, Luise, Sikorska, Beata, Liberski, Pawel P, Bartsch, Udo, Saftig, Paul, Glatzel, Markus
Publicado 2015

Pharmacological inactivation of the prion protein by targeting a folding intermediate

por Spagnolli, Giovanni, Massignan, Tania, Astolfi, Andrea, Biggi, Silvia, Rigoli, Marta, Brunelli, Paolo, Libergoli, Michela, Ianeselli, Alan, Orioli, Simone, Boldrini, Alberto, Terruzzi, Luca, Bonaldo, Valerio, Maietta, Giulia, Lorenzo, Nuria L., Fernandez, Leticia C., Codeseira, Yaiza B., Tosatto, Laura, Linsenmeier, Luise, Vignoli, Beatrice, Petris, Gianluca, Gasparotto, Dino, Pennuto, Maria, Guella, Graziano, Canossa, Marco, Altmeppen, Hermann C., Lolli, Graziano, Biressi, Stefano, Pastor, Manuel M., Requena, Jesús R., Mancini, Ines, Barreca, Maria L., Faccioli, Pietro, Biasini, Emiliano
Publicado 2021

Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies

por Linsenmeier, Luise, Mohammadi, Behnam, Shafiq, Mohsin, Frontzek, Karl, Bär, Julia, Shrivastava, Amulya N., Damme, Markus, Song, Feizhi, Schwarz, Alexander, Da Vela, Stefano, Massignan, Tania, Jung, Sebastian, Correia, Angela, Schmitz, Matthias, Puig, Berta, Hornemann, Simone, Zerr, Inga, Tatzelt, Jörg, Biasini, Emiliano, Saftig, Paul, Schweizer, Michaela, Svergun, Dmitri, Amin, Ladan, Mazzola, Federica, Varani, Luca, Thapa, Simrika, Gilch, Sabine, Schätzl, Hermann, Harris, David A., Triller, Antoine, Mikhaylova, Marina, Aguzzi, Adriano, Altmeppen, Hermann C., Glatzel, Markus
Publicado 2021

The SARS-CoV-2 main protease M(pro) causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

por Wenzel, Jan, Lampe, Josephine, Müller-Fielitz, Helge, Schuster, Raphael, Zille, Marietta, Müller, Kristin, Krohn, Markus, Körbelin, Jakob, Zhang, Linlin, Özorhan, Ümit, Neve, Vanessa, Wagner, Julian U. G., Bojkova, Denisa, Shumliakivska, Mariana, Jiang, Yun, Fähnrich, Anke, Ott, Fabian, Sencio, Valentin, Robil, Cyril, Pfefferle, Susanne, Sauve, Florent, Coêlho, Caio Fernando Ferreira, Franz, Jonas, Spiecker, Frauke, Lembrich, Beate, Binder, Sonja, Feller, Nina, König, Peter, Busch, Hauke, Collin, Ludovic, Villaseñor, Roberto, Jöhren, Olaf, Altmeppen, Hermann C., Pasparakis, Manolis, Dimmeler, Stefanie, Cinatl, Jindrich, Püschel, Klaus, Zelic, Matija, Ofengeim, Dimitry, Stadelmann, Christine, Trottein, François, Nogueiras, Ruben, Hilgenfeld, Rolf, Glatzel, Markus, Prevot, Vincent, Schwaninger, Markus
Publicado 2021