First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease

por Purgatorio, Rosa, Gambacorta, Nicola, de Candia, Modesto, Catto, Marco, Rullo, Mariagrazia, Pisani, Leonardo, Nicolotti, Orazio, Altomare, Cosimo D.
Publicado 2021

Assessing the Role of a Malonamide Linker in the Design of Potent Dual Inhibitors of Factor Xa and Cholinesterases

por Purgatorio, Rosa, Gambacorta, Nicola, Samarelli, Francesco, Lopopolo, Gianfranco, de Candia, Modesto, Catto, Marco, Nicolotti, Orazio, Altomare, Cosimo D.
Publicado 2022

Synthesis and Biological Evaluation of Dantrolene‐Like Hydrazide and Hydrazone Analogues as Multitarget Agents for Neurodegenerative Diseases

por Bolognino, Isabella, Giangregorio, Nicola, Tonazzi, Annamaria, Martínez, Antón L., Altomare, Cosimo D., Loza, María I., Sablone, Sara, Cellamare, Saverio, Catto, Marco
Publicado 2021

Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer’s Disease †

por Purgatorio, Rosa, Gambacorta, Nicola, Catto, Marco, de Candia, Modesto, Pisani, Leonardo, Espargaró, Alba, Sabaté, Raimon, Cellamare, Saverio, Nicolotti, Orazio, Altomare, Cosimo D.
Publicado 2020

Synthesis of Novel Benzo[b][1,6]naphthyridine Derivatives and Investigation of Their Potential as Scaffolds of MAO Inhibitors

por Kulikova, Larisa N., Raesi, Ghulam Reza, Levickaya, Daria D., Purgatorio, Rosa, Spada, Gabriella La, Catto, Marco, Altomare, Cosimo D., Voskressensky, Leonid G.
Publicado 2023

Investigation on Novel E/Z 2-Benzylideneindan-1-One-Based Photoswitches with AChE and MAO-B Dual Inhibitory Activity

por Paolino, Marco, de Candia, Modesto, Purgatorio, Rosa, Catto, Marco, Saletti, Mario, Tondo, Anna Rita, Nicolotti, Orazio, Cappelli, Andrea, Brizzi, Antonella, Mugnaini, Claudia, Corelli, Federico, Altomare, Cosimo D.
Publicado 2023

Synthesis of Isomeric 3-Benzazecines Decorated with Endocyclic Allene Moiety and Exocyclic Conjugated Double Bond and Evaluation of Their Anticholinesterase Activity

por Titov, Alexander A., Purgatorio, Rosa, Obydennik, Arina Y., Listratova, Anna V., Borisova, Tatiana N., de Candia, Modesto, Catto, Marco, Altomare, Cosimo D., Varlamov, Alexey V., Voskressensky, Leonid G.
Publicado 2022

Chemical and Biological Evaluation of Novel 1H-Chromeno[3,2-c]pyridine Derivatives as MAO Inhibitors Endowed with Potential Anticancer Activity

por Kulikova, Larisa N., Purgatorio, Rosa, Beloglazkin, Andrey A., Tafeenko, Viktor A., Reza, Raesi Gh., Levickaya, Daria D., Sblano, Sabina, Boccarelli, Angelina, de Candia, Modesto, Catto, Marco, Voskressensky, Leonid G., Altomare, Cosimo D.
Publicado 2023

Homobivalent Lamellarin-Like Schiff Bases: In Vitro Evaluation of Their Cancer Cell Cytotoxicity and Multitargeting Anti-Alzheimer’s Disease Potential

por Nevskaya, Alisa A., Anikina, Lada V., Purgatorio, Rosa, Catto, Marco, Nicolotti, Orazio, de Candia, Modesto, Pisani, Leonardo, Borisova, Tatiana N., Miftyakhova, Almira R., Varlamov, Aleksey V., Nevskaya, Elena Yu., Borisov, Roman S., Voskressensky, Leonid G., Altomare, Cosimo D.
Publicado 2021

Exploring Mannosylpurines as Copper Chelators and Cholinesterase Inhibitors with Potential for Alzheimer’s Disease

por Schino, Ignazio, Cantore, Mariangela, de Candia, Modesto, Altomare, Cosimo D., Maria, Catarina, Barros, João, Cachatra, Vasco, Calado, Patrícia, Shimizu, Karina, Freitas, Adilson A., Oliveira, Maria C., Ferreira, Maria J., Lopes, José N. C., Colabufo, Nicola A., Rauter, Amélia P.
Publicado 2022