Stochasticity and positive feedback enable enzyme kinetics at the membrane to sense reaction size

por Lee, Albert A., Huang, William Y. C., Hansen, Scott D., Kim, Neil H., Alvarez, Steven, Groves, Jay T.
Publicado 2021

Mechanism of SOS PR-domain autoinhibition revealed by single-molecule assays on native protein from lysate

por Lee, Young Kwang, Low-Nam, Shalini T., Chung, Jean K., Hansen, Scott D., Lam, Hiu Yue Monatrice, Alvarez, Steven, Groves, Jay T.
Publicado 2017

One-way membrane trafficking of SOS in receptor-triggered Ras activation

por Christensen, Sune M., Tu, Hsiung-Lin, Jun, Jesse E., Alvarez, Steven, Triplet, Meredith G., Iwig, Jeffrey S., Yadav, Kamlesh K., Bar-Sagi, Dafna, Roose, Jeroen P., Groves, Jay T.
Publicado 2016

A two-component protein condensate of the EGFR cytoplasmic tail and Grb2 regulates Ras activation by SOS at the membrane

por Lin, Chun-Wei, Nocka, Laura M., Stinger, Brittany L., DeGrandchamp, Joseph B., Lew, L. J. Nugent, Alvarez, Steven, Phan, Henry T., Kondo, Yasushi, Kuriyan, John, Groves, Jay T.
Publicado 2022