Finding new medicines to fight CF: multiple steps of a success story

por Amaral, Margarida D
Publicado 2012

What Can RNA-Based Therapy Do for Monogenic Diseases?

por Clarke, Luka A., Amaral, Margarida D.
Publicado 2023

What Role Does CFTR Play in Development, Differentiation, Regeneration and Cancer?

por Amaral, Margarida D., Quaresma, Margarida C., Pankonien, Ines
Publicado 2020

Cross-talk of inflammatory mediators and airway epithelium reveals the cystic fibrosis transmembrane conductance regulator as a major target

por Simões, Filipa B., Kmit, Arthur, Amaral, Margarida D.
Publicado 2021

Neuronal Reprograming of Protein Homeostasis by Calcium-Dependent Regulation of the Heat Shock Response

por Silva, M. Catarina, Amaral, Margarida D., Morimoto, Richard I.
Publicado 2013

Changes in transcriptome of native nasal epithelium expressing F508del-CFTR and intersecting data from comparable studies

por Clarke, Luka A, Sousa, Lisete, Barreto, Celeste, Amaral, Margarida D
Publicado 2013

CFTR, Cell Junctions and the Cytoskeleton

por Pankonien, Ines, Quaresma, Margarida C., Rodrigues, Cláudia S., Amaral, Margarida D.
Publicado 2022

Personalized Medicine Based on Nasal Epithelial Cells: Comparative Studies with Rectal Biopsies and Intestinal Organoids

por Silva, Iris A. L., Railean, Violeta, Duarte, Aires, Amaral, Margarida D.
Publicado 2021

Impact of KLF4 on Cell Proliferation and Epithelial Differentiation in the Context of Cystic Fibrosis

por Sousa, Luís, Pankonien, Ines, Simões, Filipa B., Chanson, Marc, Amaral, Margarida D.
Publicado 2020

Rare Trafficking CFTR Mutations Involve Distinct Cellular Retention Machineries and Require Different Rescuing Strategies

por Ramalho, Sofia S., Silva, Iris A. L., Amaral, Margarida D., Farinha, Carlos M.
Publicado 2021

Increased efficacy of VX-809 in different cellular systems results from an early stabilization effect of F508del-CFTR

por Farinha, Carlos M, Sousa, Marisa, Canato, Sara, Schmidt, André, Uliyakina, Inna, Amaral, Margarida D
Publicado 2015

KLF4 Acts as a wt-CFTR Suppressor through an AKT-Mediated Pathway

por Sousa, Luis, Pankonien, Ines, Clarke, Luka A, Silva, Iris, Kunzelmann, Karl, Amaral, Margarida D
Publicado 2020

A Genetic Screening Strategy Identifies Novel Regulators of the Proteostasis Network

por Silva, M. Catarina, Fox, Susan, Beam, Monica, Thakkar, Happy, Amaral, Margarida D., Morimoto, Richard I.
Publicado 2011

Regulation of the Epithelial Na(+) Channel by the Protein Kinase CK2

por Bachhuber, Tanja, Almaça, Joana, Aldehni, Fadi, Mehta, Anil, Amaral, Margarida D., Schreiber, Rainer, Kunzelmann, Karl
Publicado 2008

Pharmacological Modulation of Ion Channels for the Treatment of Cystic Fibrosis

por Pinto, Madalena C, Silva, Iris A L, Figueira, Miriam F, Amaral, Margarida D, Lopes-Pacheco, Miquéias
Publicado 2021

Absence of EPAC1 Signaling to Stabilize CFTR in Intestinal Organoids

por Ferreira, João F., Silva, Iris A. L., Botelho, Hugo M., Amaral, Margarida D., Farinha, Carlos M.
Publicado 2022

LMTK2-mediated Phosphorylation Regulates CFTR Endocytosis in Human Airway Epithelial Cells

por Luz, Simão, Cihil, Kristine M., Brautigan, David L., Amaral, Margarida D., Farinha, Carlos M., Swiatecka-Urban, Agnieszka
Publicado 2014

A Mathematical Model of the Phosphoinositide Pathway

por Olivença, Daniel V., Uliyakina, Inna, Fonseca, Luis L., Amaral, Margarida D., Voit, Eberhard O., Pinto, Francisco R.
Publicado 2018

Prolonged co-treatment with HGF sustains epithelial integrity and improves pharmacological rescue of Phe508del-CFTR

por Matos, Ana M., Gomes-Duarte, Andreia, Faria, Márcia, Barros, Patrícia, Jordan, Peter, Amaral, Margarida D., Matos, Paulo
Publicado 2018

Integrity and Stability of PTC Bearing CFTR mRNA and Relevance to Future Modulator Therapies in Cystic Fibrosis

por Clarke, Luka A., Luz, Vanessa C. C., Targowski, Szymon, Ramalho, Sofia S., Farinha, Carlos M., Amaral, Margarida D.
Publicado 2021