Autophagy and tumor cell invasion

por Amaravadi, Ravi K.
Publicado 2012

PUMA: a puzzle piece in chloroquine’s antimelanoma activity

por Amaravadi, Ravi K.
Publicado 2013

Targeting Autophagy in Cancer: Update on Clinical Trials and Novel Inhibitors

por Chude, Cynthia I., Amaravadi, Ravi K.
Publicado 2017

Clinical Translation of Combined MAPK and Autophagy Inhibition in RAS Mutant Cancer

por Lee, Jennifer J., Jain, Vaibhav, Amaravadi, Ravi K.
Publicado 2021

Dimeric quinacrines as chemical tools to identify PPT1, a new regulator of autophagy in cancer cells

por Nicastri, Michael C., Rebecca, Vito W., Amaravadi, Ravi K., Winkler, Jeffrey D.
Publicado 2017

A Potent Autophagy Inhibitor (Lys05) Enhances the Impact of Ionizing Radiation on Human Lung Cancer Cells H1299

por Cechakova, Lucie, Ondrej, Martin, Pavlik, Vojtech, Jost, Petr, Cizkova, Dana, Bezrouk, Ales, Pejchal, Jaroslav, Amaravadi, Ravi K., Winkler, Jeffrey D., Tichy, Ales
Publicado 2019

Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti–PD-1/PD-L1 immunotherapy

por Noman, Muhammad Zaeem, Parpal, Santiago, Van Moer, Kris, Xiao, Malina, Yu, Yasmin, Viklund, Jenny, De Milito, Angelo, Hasmim, Meriem, Andersson, Martin, Amaravadi, Ravi K., Martinsson, Jessica, Berchem, Guy, Janji, Bassam
Publicado 2020

A stratified phase I dose escalation trial of hypofractionated radiotherapy followed by ipilimumab in metastatic melanoma: long-term follow-up and final outcomes

por Maity, Amit, Mick, Rosemarie, Rengan, Ramesh, Mitchell, Tara C., Amaravadi, Ravi K., Schuchter, Lynn M., Pryma, Daniel A., Patsch, Dana M., Maity, Alisha P., Minn, Andy J., Vonderheide, Robert H., Lukens, John N.
Publicado 2021

Phase I Trial of Regorafenib, Hydroxychloroquine, and Entinostat in Metastatic Colorectal Cancer

por Karasic, Thomas B, Brown, Timothy J, Schneider, Charles, Teitelbaum, Ursina R, Reiss, Kim A, Mitchell, Tara C, Massa, Ryan C, O’Hara, Mark H, DiCicco, Lisa, Garcia-Marcano, Luis, Amaravadi, Ravi K, O’Dwyer, Peter J
Publicado 2022

Autophagy supports generation of cells with high CD44 expression via modulation of oxidative stress and Parkin-mediated mitochondrial clearance

por Whelan, Kelly A., Chandramouleeswaran, Prasanna M., Tanaka, Koji, Natsuizaka, Mitsuteru, Guha, Manti, Srinivasan, Satish, Darling, Douglas S., Kita, Yoshiaki, Natsugoe, Shoji, Winkler, Jeffrey D., Klein-Szanto, Andres J., Amaravadi, Ravi K., Avadhani, Narayan G., Rustgi, Anil. K, Nakagawa, Hiroshi
Publicado 2017

CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers

por Vijayaraghavan, Smruthi, Karakas, Cansu, Doostan, Iman, Chen, Xian, Bui, Tuyen, Yi, Min, Raghavendra, Akshara S., Zhao, Yang, Bashour, Sami I., Ibrahim, Nuhad K., Karuturi, Meghan, Wang, Jing, Winkler, Jeffrey D., Amaravadi, Ravi K., Hunt, Kelly K., Tripathy, Debu, Keyomarsi, Khandan
Publicado 2017

Moderate Colitis Not Requiring Intravenous Steroids Is Associated with Improved Survival in Stage IV Melanoma after Anti-CTLA4 Monotherapy, But Not Combination Therapy

por Anstadt, Emily J, Chu, Brian, Yegya-Raman, Nikhil, Han, Xiaoyan, Doucette, Abigail, Poirier, Kendra, Mohiuddin, Jahan J, Maity, Amit, Facciabene, Andrea, Amaravadi, Ravi K, Karakousis, Giorgos C, Cohen, Justine V, Mitchell, Tara C, Schuchter, Lynn M, Lukens, John N
Publicado 2022

Lysosomal lipid peroxidation regulates tumor immunity

por Bhardwaj, Monika, Lee, Jennifer J., Versace, Amanda M., Harper, Sandra L., Goldman, Aaron R., Crissey, Mary Ann S., Jain, Vaibhav, Singh, Mahendra Pal, Vernon, Megane, Aplin, Andrew E., Lee, Seokwoo, Morita, Masao, Winkler, Jeffrey D., Liu, Qin, Speicher, David W., Amaravadi, Ravi K.
Publicado 2023

ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumor progression

por Tameire, Feven, Verginadis, Ioannis I., Leli, Nektaria Maria, Polte, Christine, Conn, Crystal S., Ojha, Rani, Salas, Carlo, Chinga, Frank, Monroy, Alexandra. M., Fu, Weixuan, Wang, Paul, Kossenkov, Andrew, Ye, Jiangbin, Amaravadi, Ravi K., Ignatova, Zoya, Fuchs, Serge Y., Diehl, J. Alan, Ruggero, Davide, Koumenis, Constantinos
Publicado 2019

Long-term outcomes of a phase I study of agonist CD40 antibody and CTLA-4 blockade in patients with metastatic melanoma

por Bajor, David L., Mick, Rosemarie, Riese, Matthew J., Huang, Alex C., Sullivan, Brendan, Richman, Lee P., Torigian, Drew A., George, Sangeeth M., Stelekati, Erietta, Chen, Fang, Melenhorst, J. Joseph, Lacey, Simon F., Xu, Xiaowei, Wherry, E. John, Gangadhar, Tara C., Amaravadi, Ravi K., Schuchter, Lynn M., Vonderheide, Robert H.
Publicado 2018

Efficacy and Safety of Hydroxychloroquine vs Placebo for Pre-exposure SARS-CoV-2 Prophylaxis Among Health Care Workers: A Randomized Clinical Trial

por Abella, Benjamin S., Jolkovsky, Eliana L., Biney, Barbara T., Uspal, Julie E., Hyman, Matthew C., Frank, Ian, Hensley, Scott E., Gill, Saar, Vogl, Dan T., Maillard, Ivan, Babushok, Daria V., Huang, Alexander C., Nasta, Sunita D., Walsh, Jennifer C., Wiletyo, E. Paul, Gimotty, Phyllis A., Milone, Michael C., Amaravadi, Ravi K.
Publicado 2020

Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells

por McLane, Laura M., Ngiow, Shin Foong, Chen, Zeyu, Attanasio, John, Manne, Sasikanth, Ruthel, Gordon, Wu, Jennifer E., Staupe, Ryan P., Xu, Wei, Amaravadi, Ravi K., Xu, Xiaowei, Karakousis, Giorgos C., Mitchell, Tara C., Schuchter, Lynn M., Huang, Alexander C., Freedman, Bruce D., Betts, Michael R., Wherry, E. John
Publicado 2021

Targeting quiescent leukemic stem cells using second generation autophagy inhibitors

por Baquero, Pablo, Dawson, Amy, Mukhopadhyay, Arunima, Kuntz, Elodie M., Mitchell, Rebecca, Olivares, Orianne, Ianniciello, Angela, Scott, Mary T., Dunn, Karen, Nicastri, Michael C., Winkler, Jeffrey D., Michie, Alison M., Ryan, Kevin M., Halsey, Christina, Gottlieb, Eyal, Keaney, Erin P., Murphy, Leon O., Amaravadi, Ravi K., Holyoake, Tessa L., Helgason, G. Vignir
Publicado 2018

PPT1 inhibition enhances the antitumor activity of anti–PD-1 antibody in melanoma

por Sharma, Gaurav, Ojha, Rani, Noguera-Ortega, Estela, Rebecca, Vito W., Attanasio, John, Liu, Shujing, Piao, Shengfu, Lee, Jennifer J., Nicastri, Michael C., Harper, Sandra L., Ronghe, Amruta, Jain, Vaibhav, Winkler, Jeffrey D., Speicher, David W., Mastio, Jerome, Gimotty, Phyllis A., Xu, Xiaowei, Wherry, E. John, Gabrilovich, Dmitry I., Amaravadi, Ravi K.
Publicado 2020

Distinct Populations of Immune-Suppressive Macrophages Differentiate from Monocytic Myeloid-Derived Suppressor Cells in Cancer

por Kwak, Taekyoung, Wang, Fang, Deng, Hui, Condamine, Thomas, Kumar, Vinit, Perego, Michela, Kossenkov, Andrew, Montaner, Luis J., Xu, Xiaowei, Xu, Wei, Zheng, Cathy, Schuchter, Lynn M., Amaravadi, Ravi K., Mitchell, Tara C., Karakousis, Giorgos C., Mulligan, Charles, Nam, Brian, Masters, Gregory, Hockstein, Neil, Bennett, Joseph, Nefedova, Yulia, Gabrilovich, Dmitry I.
Publicado 2020