Zidovudine ameliorates pathology in the mouse model of Duchenne muscular dystrophy via P2RX7 purinoceptor antagonism

por Al-Khalidi, Rasha, Panicucci, Chiara, Cox, Paul, Chira, Natalia, Róg, Justyna, Young, Christopher N. J., McGeehan, Rhiannon E., Ambati, Kameshwari, Ambati, Jayakrishna, Zabłocki, Krzysztof, Gazzerro, Elisabetta, Arkle, Stephen, Bruno, Claudio, Górecki, Dariusz C.
Publicado 2018

A Clinical Metabolite of Azidothymidine Inhibits Experimental Choroidal Neovascularization and Retinal Pigmented Epithelium Degeneration

por Narendran, Siddharth, Pereira, Felipe, Yerramothu, Praveen, Apicella, Ivana, Wang, Shao-bin, Varshney, Akhil, Baker, Kirstie L., Marion, Kenneth M., Ambati, Meenakshi, Ambati, Vidya L., Ambati, Kameshwari, Sadda, Srinivas R., Gelfand, Bradley D., Ambati, Jayakrishna
Publicado 2020

Reduction of human Alzheimer’s disease risk and reversal of mouse model cognitive deficit with nucleoside analog use

por Magagnoli, Joseph, Yerramothu, Praveen, Ambati, Kameshwari, Cummings, Tammy, Nguyen, Joseph, Thomas, Claire C., Wang, Shao-bin, Cheng, Kaitlyn, Juraev, Maksud, Dholkawala, Roshni, Nagasaka, Ayami, Ambati, Meenakshi, Nagasaka, Yosuke, Ban, Ashley, Ambati, Vidya L., Sutton, S. Scott, Gelfand, Bradley D., Ambati, Jayakrishna
Publicado 2023

Kamuvudine-9 Protects Retinal Structure and Function in a Novel Model of Experimental Rhegmatogenous Retinal Detachment

por Huang, Peirong, Thomas, Claire C., Ambati, Kameshwari, Dholkawala, Roshni, Nagasaka, Ayami, Yerramothu, Praveen, Narendran, Siddharth, Pereira, Felipe, Nagasaka, Yosuke, Apicella, Ivana, Cai, Xiaoyu, Makin, Ryan D., Magagnoli, Joseph, Stains, Cliff I., Yin, Ruwen, Wang, Shao-bin, Gelfand, Bradley D., Ambati, Jayakrishna
Publicado 2023

Nucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-β induced retinal pigmented epithelium degeneration

por Narendran, Siddharth, Pereira, Felipe, Yerramothu, Praveen, Apicella, Ivana, Wang, Shao-bin, Ambati, Kameshwari, Hirahara, Shuichiro, Kim, Younghee, Ambati, Meenakshi, Ambati, Vidya L., Huang, Peirong, Varshney, Akhil, Nagasaka, Yosuke, Fukuda, Shinichi, Baker, Kirstie L., Marion, Kenneth M., Deussing, Jan M., Sadda, Srinivas R., Gelfand, Bradley D., Ambati, Jayakrishna
Publicado 2021

LINE-1 derepression in senescent cells triggers interferon and inflammaging

por Cecco, Marco De, Ito, Takahiro, Petrashen, Anna P., Elias, Amy E., Skvir, Nicholas J., Criscione, Steven W., Caligiana, Alberto, Brocculi, Greta, Adney, Emily M., Boeke, Jef D., Le, Oanh, Beauséjour, Christian, Ambati, Jayakrishna, Ambati, Kameshwari, Simon, Matthew, Seluanov, Andrei, Gorbunova, Vera, Slagboom, P. Eline, Helfand, Stephen L., Neretti, Nicola, Sedivy, John M.
Publicado 2019

Repurposing anti-inflammasome NRTIs for improving insulin sensitivity and reducing type 2 diabetes development

por Ambati, Jayakrishna, Magagnoli, Joseph, Leung, Hannah, Wang, Shao-bin, Andrews, Chris A., Fu, Dongxu, Pandey, Akshat, Sahu, Srabani, Narendran, Siddharth, Hirahara, Shuichiro, Fukuda, Shinichi, Sun, Jian, Pandya, Lekha, Ambati, Meenakshi, Pereira, Felipe, Varshney, Akhil, Cummings, Tammy, Hardin, James W., Edun, Babatunde, Bennett, Charles L., Ambati, Kameshwari, Fowler, Benjamin J., Kerur, Nagaraj, Röver, Christian, Leitinger, Norbert, Werner, Brian C., Stein, Joshua D., Sutton, S. Scott, Gelfand, Bradley D.
Publicado 2020

cGAS drives non-canonical inflammasome activation in age-related macular degeneration

por Kerur, Nagaraj, Fukuda, Shinichi, Banerjee, Daipayan, Kim, Younghee, Fu, Dongxu, Apicella, Ivana, Varshney, Akhil, Yasuma, Reo, Fowler, Benjamin J., Baghdasaryan, Elmira, Marion, Kenneth M., Huang, Xiwen, Yasuma, Tetsuhiro, Hirano, Yoshio, Serbulea, Vlad, Ambati, Meenakshi, Ambati, Vidya L., Kajiwara, Yuji, Ambati, Kameshwari, Bastos-Carvalho, Ana, Ogura, Yuichiro, Terasaki, Hiroko, Oshika, Tetsuro, Kim, Kyung Bo, Hinton, David R., Leitinger, Norbert, Cambier, John C., Buxbaum, Joseph D., Kenney, M. Cristina, Jazwinski, S. Michal, Nagai, Hiroshi, Hara, Isao, West, A. Phillip, Fitzgerald, Katherine A., Sadda, SriniVas R., Gelfand, Bradley D., Ambati, Jayakrishna
Publicado 2017

Alu complementary DNA is enriched in atrophic macular degeneration and triggers retinal pigmented epithelium toxicity via cytosolic innate immunity

por Fukuda, Shinichi, Narendran, Siddharth, Varshney, Akhil, Nagasaka, Yosuke, Wang, Shao-bin, Ambati, Kameshwari, Apicella, Ivana, Pereira, Felipe, Fowler, Benjamin J., Yasuma, Tetsuhiro, Hirahara, Shuichiro, Yasuma, Reo, Huang, Peirong, Yerramothu, Praveen, Makin, Ryan D., Wang, Mo, Baker, Kirstie L., Marion, Kenneth M., Huang, Xiwen, Baghdasaryan, Elmira, Ambati, Meenakshi, Ambati, Vidya L., Banerjee, Daipayan, Bonilha, Vera L., Tolstonog, Genrich V., Held, Ulrike, Ogura, Yuichiro, Terasaki, Hiroko, Oshika, Tetsuro, Bhattarai, Deepak, Kim, Kyung Bo, Feldman, Sanford H., Aguirre, J. Ignacio, Hinton, David R., Kerur, Nagaraj, Sadda, Srinivas R., Schumann, Gerald G., Gelfand, Bradley D., Ambati, Jayakrishna
Publicado 2021