The Feasibility of Enzyme Targeted Activation for Amino Acid/Dipeptide Monoester Prodrugs of Floxuridine; Cathepsin D as a Potential Targeted Enzym

por Tsume, Yasuhiro, Amidon, Gordon L.
Publicado 2012

Enhanced Cancer Cell Growth Inhibition by Dipeptide Prodrugs of Floxuridine: Increased Transporter Affinity and Metabolic Stability

por Tsume, Yasuhiro, Hilfinger, John M., Amidon, Gordon L.
Publicado 2008

The Dipeptide Monoester Prodrugs of Floxuridine and Gemcitabine—Feasibility of Orally Administrable Nucleoside Analogs

por Tsume, Yasuhiro, Bermejo, Blanca Borras, Amidon, Gordon L.
Publicado 2014

An improved synthesis of a fluorophosphonate–polyethylene glycol–biotin probe and its use against competitive substrates

por Xu, Hao, Sabit, Hairat, Amidon, Gordon L, Showalter, H D Hollis
Publicado 2013

Mechanistic Analysis of Cocrystal Dissolution as a Function of pH and Micellar Solubilization

por Cao, Fengjuan, Amidon, Gordon L., Rodriguez-Hornedo, Nair, Amidon, Gregory E.
Publicado 2016

Potential Development of Tumor-Targeted Oral Anti-Cancer Prodrugs: Amino Acid and Dipeptide Monoester Prodrugs of Gemcitabine

por Tsume, Yasuhiro, Drelich, Adam J., Smith, David E., Amidon, Gordon L.
Publicado 2017

Application of the Gastrointestinal Simulator (GIS) Coupled with In Silico Modeling to Measure the Impact of Coca-Cola(®) on the Luminal and Systemic Behavior of Loratadine (BCS Cl...

por Hens, Bart, Bermejo, Marival, Cristofoletti, Rodrigo, Amidon, Gregory E., Amidon, Gordon L.
Publicado 2020

Erratum: Hens, B.; et al. Application of the Gastrointestinal Simulator (GIS) Coupled with In Silico Modeling to Measure the Impact of Coca-Cola(®) on the Luminal and Systemic Beha...

por Hens, Bart, Bermejo, Marival, Augustijns, Patrick, Cristofoletti, Rodrigo, Amidon, Gregory E., Amidon, Gordon L.
Publicado 2020

The Role of Paracellular Transport in the Intestinal Absorption and Biopharmaceutical Characterization of Minoxidil

por Markovic, Milica, Zur, Moran, Garsiani, Sapir, Porat, Daniel, Cvijić, Sandra, Amidon, Gordon L., Dahan, Arik
Publicado 2022

Dipeptidyl Peptidase IV as a Potential Target for Selective Prodrug Activation and Chemotherapeutic Action in Cancers

por Dahan, Arik, Wolk, Omri, Yang, Peihua, Mittal, Sachin, Wu, Zhiqian, Landowski, Christopher P., Amidon, Gordon L.
Publicado 2014

Enhanced Absorption and Growth Inhibition with Amino Acid Monoester Prodrugs of Floxuridine by Targeting hPEPT1 Transporters

por Tsume, Yasuhiro, Vig, Balvinder S., Sun, Jing, Landowski, Christopher P., Hilfinger, John M., Ramachandran, Chandrasekharan, Amidon, Gordon L
Publicado 2008

A Mechanistic Physiologically-Based Biopharmaceutics Modeling (PBBM) Approach to Assess the In Vivo Performance of an Orally Administered Drug Product: From IVIVC to IVIVP

por Bermejo, Marival, Hens, Bart, Dickens, Joseph, Mudie, Deanna, Paixão, Paulo, Tsume, Yasuhiro, Shedden, Kerby, Amidon, Gordon L.
Publicado 2020

Cytomegalovirus Protease Targeted Prodrug Development

por Sabit, Hairat, Dahan, Arik, Sun, Jing, Provoda, Chester J., Lee, Kyung-Dall, Hilfinger, John H., Amidon, Gordon L.
Publicado 2013

Biphasic Dissolution as an Exploratory Method during Early Drug Product Development

por Amaral Silva, Daniela, Al-Gousous, Jozef, Davies, Neal M., Bou Chacra, Nadia, Webster, Gregory K., Lipka, Elke, Amidon, Gordon L., Löbenberg, Raimar
Publicado 2020

An In Vivo Predictive Dissolution Methodology (iPD Methodology) with a BCS Class IIb Drug Can Predict the In Vivo Bioequivalence Results: Etoricoxib Products

por Gonzalez-Alvarez, Isabel, Bermejo, Marival, Tsume, Yasuhiro, Ruiz-Picazo, Alejandro, Gonzalez-Alvarez, Marta, Hens, Bart, Garcia-Arieta, Alfredo, Amidon, Greg E., Amidon, Gordon L.
Publicado 2021

Propagation Characteristics of Fasting Duodeno-Jejunal Contractions in Healthy Controls Measured by Clustered Closely-spaced Manometric Sensors

por Baker, Jason R, Dickens, Joseph R, Koenigsknecht, Mark, Frances, Ann, Lee, Allen A, Shedden, Kerby A, Brasseur, James G, Amidon, Gordon L, Sun, Duxin, Hasler, William L
Publicado 2019

Exploring Bioequivalence of Dexketoprofen Trometamol Drug Products with the Gastrointestinal Simulator (GIS) and Precipitation Pathways Analyses

por Bermejo, Marival, Kuminek, Gislaine, Al-Gousous, Jozef, Ruiz-Picazo, Alejandro, Tsume, Yasuhiro, Garcia-Arieta, Alfredo, González-Alvarez, Isabel, Hens, Bart, Mudie, Deanna, Amidon, Gregory E., Rodriguez-Hornedo, Nair, Amidon, Gordon L.
Publicado 2019

Measurement of fasted state gastric antral motility before and after a standard bioavailability and bioequivalence 240 mL drink of water: Validation of MRI method against concomita...

por Heissam, Khaled, Abrehart, Nichola, Hoad, Caroline L., Wright, Jeff, Menys, Alex, Murray, Kathryn, Glover, Paul M., Hebbard, Geoffrey, Gowland, Penny A., Baker, Jason, Hasler, William L., Spiller, Robin C., Corsetti, Maura, Brasseur, James G., Hens, Bart, Shedden, Kerby, Dickens, Joseph, Mudie, Deanna M., Amidon, Greg E., Amidon, Gordon L., Marciani, Luca
Publicado 2020