Pancreatic Cancer Chemoresistance to Gemcitabine

por Amrutkar, Manoj, Gladhaug, Ivar P.
Publicado 2017

Stellate Cells Aid Growth-Permissive Metabolic Reprogramming and Promote Gemcitabine Chemoresistance in Pancreatic Cancer

por Amrutkar, Manoj, Gladhaug, Ivar P.
Publicado 2021

Secretion of fibronectin by human pancreatic stellate cells promotes chemoresistance to gemcitabine in pancreatic cancer cells

por Amrutkar, Manoj, Aasrum, Monica, Verbeke, Caroline S., Gladhaug, Ivar P.
Publicado 2019

Fatty acids abrogate the growth-suppressive effects induced by inhibition of cholesterol flux in pancreatic cancer cells

por Li, Yuchuan, Amrutkar, Manoj, Finstadsveen, Anette Vefferstad, Dalen, Knut Tomas, Verbeke, Caroline S., Gladhaug, Ivar P.
Publicado 2023

Neoadjuvant chemotherapy is associated with an altered metabolic profile and increased cancer stemness in patients with pancreatic ductal adenocarcinoma

por Amrutkar, Manoj, Verbeke, Caroline S., Finstadsveen, Anette Vefferstad, Dorg, Linda, Labori, Knut Jørgen, Gladhaug, Ivar P.
Publicado 2022

Commonly Used Pancreatic Stellate Cell Cultures Differ Phenotypically and in Their Interactions with Pancreatic Cancer Cells

por Lenggenhager, Daniela, Amrutkar, Manoj, Sántha, Petra, Aasrum, Monica, Löhr, Johannes-Matthias, Gladhaug, Ivar P., Verbeke, Caroline S.
Publicado 2019

Differential Gemcitabine Sensitivity in Primary Human Pancreatic Cancer Cells and Paired Stellate Cells Is Driven by Heterogenous Drug Uptake and Processing

por Amrutkar, Manoj, Vethe, Nils Tore, Verbeke, Caroline S., Aasrum, Monica, Finstadsveen, Anette Vefferstad, Sántha, Petra, Gladhaug, Ivar P.
Publicado 2020

Morphological Heterogeneity in Pancreatic Cancer Reflects Structural and Functional Divergence

por Sántha, Petra, Lenggenhager, Daniela, Finstadsveen, Anette, Dorg, Linda, Tøndel, Kristin, Amrutkar, Manoj, Gladhaug, Ivar P., Verbeke, Caroline
Publicado 2021

Establishment and Characterization of Paired Primary Cultures of Human Pancreatic Cancer Cells and Stellate Cells Derived from the Same Tumor

por Amrutkar, Manoj, Larsen, Emma Kristine, Aasrum, Monica, Finstadsveen, Anette Vefferstad, Andresen, Per Arne, Verbeke, Caroline S., Gladhaug, Ivar P.
Publicado 2020

Pancreatic stellate cell-induced gemcitabine resistance in pancreatic cancer is associated with LDHA- and MCT4-mediated enhanced glycolysis

por Amrutkar, Manoj, Berg, Kjersti, Balto, Aina, Skilbrei, Miguel G., Finstadsveen, Anette V., Aasrum, Monica, Gladhaug, Ivar P., Verbeke, Caroline S.
Publicado 2023

Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic Fatty Liver Disease

por Cansby, Emmelie, Nuñez-Durán, Esther, Magnusson, Elin, Amrutkar, Manoj, Booten, Sheri L., Kulkarni, Nagaraj M., Svensson, L. Thomas, Borén, Jan, Marschall, Hanns-Ulrich, Aghajan, Mariam, Mahlapuu, Margit
Publicado 2018

Overexpression of protein kinase STK25 in mice exacerbates ectopic lipid accumulation, mitochondrial dysfunction and insulin resistance in skeletal muscle

por Chursa, Urszula, Nuñez-Durán, Esther, Cansby, Emmelie, Amrutkar, Manoj, Sütt, Silva, Ståhlman, Marcus, Olsson, Britt-Marie, Borén, Jan, Johansson, Maria E., Bäckhed, Fredrik, Johansson, Bengt R., Sihlbom, Carina, Mahlapuu, Margit
Publicado 2016

Genetic Disruption of Protein Kinase STK25 Ameliorates Metabolic Defects in a Diet-Induced Type 2 Diabetes Model

por Amrutkar, Manoj, Cansby, Emmelie, Chursa, Urszula, Nuñez-Durán, Esther, Chanclón, Belén, Ståhlman, Marcus, Fridén, Vincent, Mannerås-Holm, Louise, Wickman, Anna, Smith, Ulf, Bäckhed, Fredrik, Borén, Jan, Howell, Brian W., Mahlapuu, Margit
Publicado 2015

Serine/threonine protein kinase 25 antisense oligonucleotide treatment reverses glucose intolerance, insulin resistance, and nonalcoholic fatty liver disease in mice

por Nuñez‐Durán, Esther, Aghajan, Mariam, Amrutkar, Manoj, Sütt, Silva, Cansby, Emmelie, Booten, Sheri L., Watt, Andrew, Ståhlman, Marcus, Stefan, Norbert, Häring, Hans‐Ulrich, Staiger, Harald, Borén, Jan, Marschall, Hanns‐Ulrich, Mahlapuu, Margit
Publicado 2017