Enzyme Architecture: Remarkably Similar Transition States for Triosephosphate Isomerase-Catalyzed Reactions of the Whole Substrate and the Substrate in Pieces

por Zhai, Xiang, Amyes, Tina L., Richard, John P.
Publicado 2014

Role of Loop-Clamping Side Chains in Catalysis by Triosephosphate Isomerase

por Zhai, Xiang, Amyes, Tina L., Richard, John P.
Publicado 2015

Role of the Carboxylate in Enzyme-Catalyzed Decarboxylation of Orotidine 5′-Monophosphate: Transition State Stabilization Dominates Over Ground State Destabilization

por Goryanova, Bogdana, Amyes, Tina L., Richard, John P.
Publicado 2019

Enzyme Architecture: A Startling Role for Asn270 in Glycerol 3-Phosphate Dehydrogenase-Catalyzed Hydride Transfer

por Reyes, Archie C., Amyes, Tina L., Richard, John P.
Publicado 2016

Structure–Reactivity Effects on Intrinsic Primary Kinetic Isotope Effects for Hydride Transfer Catalyzed by Glycerol-3-phosphate Dehydrogenase

por Reyes, Archie C., Amyes, Tina L., Richard, John P.
Publicado 2016

Enzyme Architecture: Self-Assembly of Enzyme and Substrate Pieces of Glycerol-3-Phosphate Dehydrogenase into a Robust Catalyst of Hydride Transfer

por Reyes, Archie C., Amyes, Tina L., Richard, John P.
Publicado 2016

Enzyme Architecture: Erection of Active Orotidine 5′-Monophosphate Decarboxylase by Substrate-Induced Conformational Changes

por Reyes, Archie C., Amyes, Tina L., Richard, John P.
Publicado 2017

Orotidine 5′-Monophosphate Decarboxylase: Probing the Limits of the Possible for Enzyme Catalysis

por Richard, John P., Amyes, Tina L., Reyes, Archie C.
Publicado 2018

Primary Deuterium Kinetic Isotope Effects: A Probe for the Origin of the Rate Acceleration for Hydride Transfer Catalyzed by Glycerol-3-Phosphate Dehydrogenase

por Reyes, Archie C., Amyes, Tina L., Richard, John P.
Publicado 2018

Linear Free Energy Relationships for Enzymatic Reactions: Fresh Insight from a Venerable Probe

por Richard, John P., Cristobal, Judith R., Amyes, Tina L.
Publicado 2021

Enzyme Architecture: The Role of a Flexible Loop in Activation of Glycerol-3-phosphate Dehydrogenase for Catalysis of Hydride Transfer

por He, Rui, Reyes, Archie C., Amyes, Tina L., Richard, John P.
Publicado 2018

Enzyme Architecture: Optimization of Transition State Stabilization from a Cation–Phosphodianion Pair

por Reyes, Archie C., Koudelka, Astrid P., Amyes, Tina L., Richard, John P.
Publicado 2015

Uncovering the Role of Key Active-Site Side Chains in Catalysis: An Extended Brønsted Relationship for Substrate Deprotonation Catalyzed by Wild-Type and Variants of Triosephosphat...

por Kulkarni, Yashraj S., Amyes, Tina L., Richard, John P., Kamerlin, Shina C. L.
Publicado 2019

Enzyme Architecture: Deconstruction of the Enzyme-Activating Phosphodianion Interactions of Orotidine 5′-Monophosphate Decarboxylase

por Goldman, Lawrence M., Amyes, Tina L., Goryanova, Bogdana, Gerlt, John A., Richard, John P.
Publicado 2014

Enzyme Architecture: Amino Acid Side-Chains That Function To Optimize the Basicity of the Active Site Glutamate of Triosephosphate Isomerase

por Zhai, Xiang, Reinhardt, Christopher J., Malabanan, M. Merced, Amyes, Tina L., Richard, John P.
Publicado 2018

Phosphodianion Activation of Enzymes for Catalysis of Central Metabolic Reactions

por Fernandez, Patrick L., Nagorski, Richard W., Cristobal, Judith R., Amyes, Tina L., Richard, John P.
Publicado 2021

The Activating Oxydianion Binding Domain for Enzyme-Catalyzed Proton Transfer, Hydride Transfer, and Decarboxylation: Specificity and Enzyme Architecture

por Reyes, Archie C., Zhai, Xiang, Morgan, Kelsey T., Reinhardt, Christopher J., Amyes, Tina L., Richard, John P.
Publicado 2015

Rate and Equilibrium Constants for an Enzyme Conformational Change during Catalysis by Orotidine 5′-Monophosphate Decarboxylase

por Goryanova, Bogdana, Goldman, Lawrence M., Ming, Shonoi, Amyes, Tina L., Gerlt, John A., Richard, John P.
Publicado 2015

Role of Ligand-Driven Conformational Changes in Enzyme Catalysis: Modeling the Reactivity of the Catalytic Cage of Triosephosphate Isomerase

por Kulkarni, Yashraj S., Liao, Qinghua, Byléhn, Fabian, Amyes, Tina L., Richard, John P., Kamerlin, Shina C. L.
Publicado 2018

Enzyme Architecture: Breaking Down the Catalytic Cage that Activates Orotidine 5′-Monophosphate Decarboxylase for Catalysis

por Reyes, Archie C., Plache, David C., Koudelka, Astrid P., Amyes, Tina L., Gerlt, John A., Richard, John P.
Publicado 2018