Nanobodies Provide Insight into the Molecular Mechanisms of the Complement Cascade and Offer New Therapeutic Strategies

por Zarantonello, Alessandra, Pedersen, Henrik, Laursen, Nick S., Andersen, Gregers R.
Publicado 2021

Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer

por Yatime, Laure, Maasch, Christian, Hoehlig, Kai, Klussmann, Sven, Andersen, Gregers R., Vater, Axel
Publicado 2015

α(2)-Macroglobulin Can Crosslink Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Molecules and May Facilitate Adhesion of Parasitized Erythrocytes

por Stevenson, Liz, Laursen, Erik, Cowan, Graeme J., Bandoh, Betty, Barfod, Lea, Cavanagh, David R., Andersen, Gregers R., Hviid, Lars
Publicado 2015

Properdin oligomers adopt rigid extended conformations supporting function

por Pedersen, Dennis V, Pedersen, Martin Nors, Mazarakis, Sofia MM, Wang, Yong, Lindorff-Larsen, Kresten, Arleth, Lise, Andersen, Gregers R
Publicado 2021

Functional and Structural Characterization of a Potent C1q Inhibitor Targeting the Classical Pathway of the Complement System

por Laursen, Nick S., Pedersen, Dennis V., Gytz, Heidi, Zarantonello, Alessandra, Bernth Jensen, Jens Magnus, Hansen, Annette G., Thiel, Steffen, Andersen, Gregers R.
Publicado 2020

Structure and function of a family of tick-derived complement inhibitors targeting properdin

por Braunger, Katharina, Ahn, Jiyoon, Jore, Matthijs M., Johnson, Steven, Tang, Terence T. L., Pedersen, Dennis V., Andersen, Gregers R., Lea, Susan M.
Publicado 2022

Synergistic activation of eIF4A by eIF4B and eIF4G

por Nielsen, Klaus H., Behrens, Manja A., He, Yangzi, Oliveira, Cristiano L. P., Sottrup Jensen, Lars, Hoffmann, Søren V., Pedersen, Jan S., Andersen, Gregers R.
Publicado 2011

A Single-Domain Antibody Targeting Complement Component C5 Acts as a Selective Inhibitor of the Terminal Pathway of the Complement System and Thus Functionally Mimicks the C-Termin...

por Yatime, Laure, Merle, Nicolas S., Hansen, Annette G., Friis, Niels Anton, Østergaard, Jakob A., Bjerre, Mette, Roumenina, Lubka T., Thiel, Steffen, Kristensen, Peter, Andersen, Gregers R.
Publicado 2018

Mutation-induced dimerization of transforming growth factor-β–induced protein may drive protein aggregation in granular corneal dystrophy

por Nielsen, Nadia Sukusu, Gadeberg, Trine A.F., Poulsen, Ebbe Toftgaard, Harwood, Seandean Lykke, Weberskov, Christian E., Pedersen, Jan Skov, Andersen, Gregers R., Enghild, Jan J.
Publicado 2021

Structural and functional analyses of antibodies specific for modified core N‐glycans suggest a role in T(H)2 responses

por Plum, Melanie, Tjerrild, Luna, Raiber, Tim, Bantleon, Frank, Bantleon, Sara, Miehe, Michaela, Jabs, Frederic, Seismann, Henning, Möbs, Christian, Pfützner, Wolfgang, Jakob, Thilo, Andersen, Gregers R., Spillner, Edzard
Publicado 2022

Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family

por Nielsen, Nadia Sukusu, Zarantonello, Alessandra, Harwood, Seandean Lykke, Jensen, Kathrine Tejlgård, Kjøge, Katarzyna, Thøgersen, Ida B., Schauser, Leif, Karlsen, Jesper Lykkegaard, Andersen, Gregers R., Enghild, Jan J.
Publicado 2022

ITIH4 acts as a protease inhibitor by a novel inhibitory mechanism

por Pihl, Rasmus, Jensen, Rasmus K., Poulsen, Emil C., Jensen, Lisbeth, Hansen, Annette G., Thøgersen, Ida B., Dobó, József, Gál, Péter, Andersen, Gregers R., Enghild, Jan J., Thiel, Steffen
Publicado 2021

Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts FcεRI interaction

por Jabs, Frederic, Plum, Melanie, Laursen, Nick S., Jensen, Rasmus K., Mølgaard, Brian, Miehe, Michaela, Mandolesi, Marco, Rauber, Michèle M., Pfützner, Wolfgang, Jakob, Thilo, Möbs, Christian, Andersen, Gregers R., Spillner, Edzard
Publicado 2018

Novel homozygous CD46 variant with C‐isoform expression affects C3b inactivation in atypical hemolytic uremic syndrome

por Schack, Vivien R., Herlin, Morten K., Pedersen, Henrik, Jensen, J. Magnus Bernth, Færch, Mia, Bundgaard, Bettina, Jensen, Rasmus K., Jensen, Uffe B., Christensen, Rikke, Andersen, Gregers R., Thiel, Steffen, Höllsberg, Per
Publicado 2022

Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System

por Pedersen, Dennis V., Gadeberg, Trine A. F., Thomas, Caroline, Wang, Yong, Joram, Nicolas, Jensen, Rasmus K., Mazarakis, Sofia M. M., Revel, Margot, El Sissy, Carine, Petersen, Steen V., Lindorff-Larsen, Kresten, Thiel, Steffen, Laursen, Nick S., Fremeaux-Bacchi, Véronique, Andersen, Gregers R.
Publicado 2019