Cannabis constituents interact at the drug efflux pump BCRP to markedly increase plasma cannabidiolic acid concentrations

por Anderson, Lyndsey L., Etchart, Maia G., Bahceci, Dilara, Golembiewski, Taliesin A., Arnold, Jonathon C.
Publicado 2021

Beyond CBD: Inhibitory effects of lesser studied phytocannabinoids on human voltage-gated sodium channels

por Milligan, Carol J., Anderson, Lyndsey L., McGregor, Iain S., Arnold, Jonathon C., Petrou, Steven
Publicado 2023

Ictal vocalizations in the Scn1a (+/−) mouse model of Dravet syndrome

por Anderson, Lyndsey L., Everett‐Morgan, Declan, Petkova, Stela P., Silverman, Jill L., Arnold, Jonathon C.
Publicado 2023

Fine Mapping of a Dravet Syndrome Modifier Locus on Mouse Chromosome 5 and Candidate Gene Analysis by RNA-Seq

por Hawkins, Nicole A., Zachwieja, Nicole J., Miller, Alison R., Anderson, Lyndsey L., Kearney, Jennifer A.
Publicado 2016

Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome

por Anderson, Lyndsey L., Hawkins, Nicole A., Thompson, Christopher H., Kearney, Jennifer A., George, Alfred L.
Publicado 2017

Screening of conventional anticonvulsants in a genetic mouse model of epilepsy

por Hawkins, Nicole A., Anderson, Lyndsey L., Gertler, Tracy S., Laux, Linda, George, Alfred L., Kearney, Jennifer A.
Publicado 2017

The Heat Sensing Trpv1 Receptor Is Not a Viable Anticonvulsant Drug Target in the Scn1a (+/−) Mouse Model of Dravet Syndrome

por Satpute Janve, Vaishali, Anderson, Lyndsey L., Bahceci, Dilara, Hawkins, Nicole A., Kearney, Jennifer A., Arnold, Jonathon C.
Publicado 2021

Olivetolic acid, a cannabinoid precursor in Cannabis sativa, but not CBGA methyl ester exhibits a modest anticonvulsant effect in a mouse model of Dravet syndrome

por Anderson, Lyndsey L., Udoh, Michael, Everett-Morgan, Declan, Heblinski, Marika, McGregor, Iain S., Banister, Samuel D., Arnold, Jonathon C.
Publicado 2022

A nutraceutical product, extracted from Cannabis sativa, modulates voltage-gated sodium channel function

por Milligan, Carol J., Anderson, Lyndsey L., Bowen, Michael T., Banister, Samuel D., McGregor, Iain S., Arnold, Jonathon C., Petrou, Steven
Publicado 2022

The anticonvulsant phytocannabinoids CBGVA and CBDVA inhibit recombinant T-type channels

por Udoh, Michael, Bladen, Chris, Heblinski, Marika, Luo, Jia Lin, Janve, Vaishali S., Anderson, Lyndsey L., McGregor, Iain S., Arnold, Jonathon C.
Publicado 2022

An Examination of the Anti-Cancer Properties of Plant Cannabinoids in Preclinical Models of Mesothelioma

por Colvin, Emily K., Hudson, Amanda L., Anderson, Lyndsey L., Kumar, Ramyashree Prasanna, McGregor, Iain S., Howell, Viive M., Arnold, Jonathon C.
Publicado 2022

Heterozygous deletion of Gpr55 does not affect a hyperthermia-induced seizure, spontaneous seizures or survival in the Scn1a(+/)(-) mouse model of Dravet syndrome

por Anderson, Lyndsey L., Bahceci, Dilara A., Hawkins, Nicole A., Everett-Morgan, Declan, Banister, Samuel D., Kearney, Jennifer A., Arnold, Jonathon C.
Publicado 2023

Evaluation of the Possible Anticonvulsant Effect of Δ(9)-Tetrahydrocannabinolic Acid in Murine Seizure Models

por Benson, Melissa J., Anderson, Lyndsey L., Low, Ivan K., Luo, Jia Lin, Kevin, Richard C., Zhou, Cilla, McGregor, Iain S., Arnold, Jonathon C.
Publicado 2022

Coadministered cannabidiol and clobazam: Preclinical evidence for both pharmacodynamic and pharmacokinetic interactions

por Anderson, Lyndsey L., Absalom, Nathan L., Abelev, Sarah V., Low, Ivan K., Doohan, Peter T., Martin, Lewis J., Chebib, Mary, McGregor, Iain S., Arnold, Jonathon C.
Publicado 2019

Cannabigerolic acid, a major biosynthetic precursor molecule in cannabis, exhibits divergent effects on seizures in mouse models of epilepsy

por Anderson, Lyndsey L., Heblinski, Marika, Absalom, Nathan L., Hawkins, Nicole A., Bowen, Michael T., Benson, Melissa J., Zhang, Fan, Bahceci, Dilara, Doohan, Peter T., Chebib, Mary, McGregor, Iain S., Kearney, Jennifer A., Arnold, Jonathon C.
Publicado 2021

MEPIRAPIM-derived synthetic cannabinoids inhibit T-type calcium channels with divergent effects on seizures in rodent models of epilepsy

por Harman, Thomas, Udoh, Michael, McElroy, Dan L., Anderson, Lyndsey L., Kevin, Richard C., Banister, Samuel D., Ametovski, Adam, Markham, Jack, Bladen, Chris, Doohan, Peter T., Greba, Quentin, Laprairie, Robert B., Snutch, Terrance P., McGregor, Iain S., Howland, John G., Arnold, Jonathon C.
Publicado 2023