Influence of Proteome Profiles and Intracellular Drug Exposure on Differences in CYP Activity in Donor-Matched Human Liver Microsomes and Hepatocytes

por Wegler, Christine, Matsson, Pär, Krogstad, Veronica, Urdzik, Jozef, Christensen, Hege, Andersson, Tommy B., Artursson, Per
Publicado 2021

Evaluation of 1β-Hydroxylation of Deoxycholic Acid as a Non-Invasive Urinary Biomarker of CYP3A Activity in the Assessment of Inhibition-Based Drug–Drug Interaction in Healthy Volu...

por Li, Xue-Qing, Thelingwani, Roslyn Stella, Bertilsson, Leif, Diczfalusy, Ulf, Andersson, Tommy B., Masimirembwa, Collen
Publicado 2021

Transcriptional, Functional, and Mechanistic Comparisons of Stem Cell–Derived Hepatocytes, HepaRG Cells, and Three-Dimensional Human Hepatocyte Spheroids as Predictive In Vitro Sys...

por Bell, Catherine C., Lauschke, Volker M., Vorrink, Sabine U., Palmgren, Henrik, Duffin, Rodger, Andersson, Tommy B., Ingelman-Sundberg, Magnus
Publicado 2017

Global variability analysis of mRNA and protein concentrations across and within human tissues

por Wegler, Christine, Ölander, Magnus, Wiśniewski, Jacek R, Lundquist, Patrik, Zettl, Katharina, Åsberg, Anders, Hjelmesæth, Jøran, Andersson, Tommy B, Artursson, Per
Publicado 2019

Human Pluripotent Stem Cell-Derived Hepatocytes Show Higher Transcriptional Correlation with Adult Liver Tissue than with Fetal Liver Tissue

por Ghosheh, Nidal, Küppers-Munther, Barbara, Asplund, Annika, Andersson, Christian X., Björquist, Petter, Andersson, Tommy B., Carén, Helena, Simonsson, Stina, Sartipy, Peter, Synnergren, Jane
Publicado 2020

Integrated experimental-computational analysis of a HepaRG liver-islet microphysiological system for human-centric diabetes research

por Casas, Belén, Vilén, Liisa, Bauer, Sophie, Kanebratt, Kajsa P., Wennberg Huldt, Charlotte, Magnusson, Lisa, Marx, Uwe, Andersson, Tommy B., Gennemark, Peter, Cedersund, Gunnar
Publicado 2022

Proteomics‐Informed Prediction of Rosuvastatin Plasma Profiles in Patients With a Wide Range of Body Weight

por Wegler, Christine, Prieto Garcia, Luna, Klinting, Signe, Robertsen, Ida, Wiśniewski, Jacek R., Hjelmesæth, Jøran, Åsberg, Anders, Jansson‐Löfmark, Rasmus, Andersson, Tommy B., Artursson, Per
Publicado 2020

Drug Disposition Protein Quantification in Matched Human Jejunum and Liver From Donors With Obesity

por Wegler, Christine, Wiśniewski, Jacek R., Robertsen, Ida, Christensen, Hege, Kristoffer Hertel, Jens, Hjelmesæth, Jøran, Jansson‐Löfmark, Rasmus, Åsberg, Anders, Andersson, Tommy B., Artursson, Per
Publicado 2022

Highly Synchronized Expression of Lineage-Specific Genes during In Vitro Hepatic Differentiation of Human Pluripotent Stem Cell Lines

por Ghosheh, Nidal, Olsson, Björn, Edsbagge, Josefina, Küppers-Munther, Barbara, Van Giezen, Mariska, Asplund, Annika, Andersson, Tommy B., Björquist, Petter, Carén, Helena, Simonsson, Stina, Sartipy, Peter, Synnergren, Jane
Publicado 2016

Validation of in vitro methods for human cytochrome P450 enzyme induction: Outcome of a multi-laboratory study

por Bernasconi, Camilla, Pelkonen, Olavi, Andersson, Tommy B., Strickland, Judy, Wilk-Zasadna, Iwona, Asturiol, David, Cole, Thomas, Liska, Roman, Worth, Andrew, Müller-Vieira, Ursula, Richert, Lysiane, Chesne, Christophe, Coecke, Sandra
Publicado 2019

Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model

por Bauer, Sophie, Wennberg Huldt, Charlotte, Kanebratt, Kajsa P., Durieux, Isabell, Gunne, Daniela, Andersson, Shalini, Ewart, Lorna, Haynes, William G., Maschmeyer, Ilka, Winter, Annika, Ämmälä, Carina, Marx, Uwe, Andersson, Tommy B.
Publicado 2017

Publisher Correction: Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model

por Bauer, Sophie, Wennberg Huldt, Charlotte, Kanebratt, Kajsa P., Durieux, Isabell, Gunne, Daniela, Andersson, Shalini, Ewart, Lorna, Haynes, William G., Maschmeyer, Ilka, Winter, Annika, Ämmälä, Carina, Marx, Uwe, Andersson, Tommy B.
Publicado 2018

Impact of body weight, low energy diet and gastric bypass on drug bioavailability, cardiovascular risk factors and metabolic biomarkers: protocol for an open, non-randomised, three...

por Hjelmesæth, Jøran, Åsberg, Anders, Andersson, Shalini, Sandbu, Rune, Robertsen, Ida, Johnson, Line Kristin, Angeles, Philip Carlo, Hertel, Jens Kristoffer, Skovlund, Eva, Heijer, Maria, Ek, Anna-Lena, Krogstad, Veronica, Karlsen, Tor-Ivar, Christensen, Hege, Andersson, Tommy B, Karlsson, Cecilia
Publicado 2018

The TM6SF2 E167K genetic variant induces lipid biosynthesis and reduces apolipoprotein B secretion in human hepatic 3D spheroids

por Prill, Sebastian, Caddeo, Andrea, Baselli, Guido, Jamialahmadi, Oveis, Dongiovanni, Paola, Rametta, Raffaela, Kanebratt, Kajsa P., Pujia, Arturo, Pingitore, Piero, Mancina, Rosellina Margherita, Lindén, Daniel, Whatling, Carl, Janefeldt, Annika, Kozyra, Mikael, Ingelman-Sundberg, Magnus, Valenti, Luca, Andersson, Tommy B., Romeo, Stefano
Publicado 2019

Short‐ and long‐term effects of body weight loss following calorie restriction and gastric bypass on CYP3A‐activity – a non‐randomized three‐armed controlled trial

por Kvitne, Kine Eide, Robertsen, Ida, Skovlund, Eva, Christensen, Hege, Krogstad, Veronica, Wegler, Christine, Angeles, Philip Carlo, Wollmann, Birgit Malene, Hole, Kristine, Johnson, Line Kristin, Sandbu, Rune, Artursson, Per, Karlsson, Cecilia, Andersson, Shalini, Andersson, Tommy B., Hjelmesæth, Jøran, Jansson‐Löfmark, Rasmus, Åsberg, Anders
Publicado 2021

Correlations between 4β-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body wei...

por Eide Kvitne, Kine, Hole, Kristine, Krogstad, Veronica, Wollmann, Birgit Malene, Wegler, Christine, Johnson, Line K., Hertel, Jens K., Artursson, Per, Karlsson, Cecilia, Andersson, Shalini, Andersson, Tommy B., Sandbu, Rune, Hjelmesæth, Jøran, Skovlund, Eva, Christensen, Hege, Jansson-Löfmark, Rasmus, Åsberg, Anders, Molden, Espen, Robertsen, Ida
Publicado 2022

Short‐ and long‐term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity

por Kvitne, Kine Eide, Krogstad, Veronica, Wegler, Christine, Johnson, Line Kristin, Kringen, Marianne K., Hovd, Markus Herberg, Hertel, Jens K., Heijer, Maria, Sandbu, Rune, Skovlund, Eva, Artursson, Per, Karlsson, Cecilia, Andersson, Shalini, Andersson, Tommy B., Hjelmesæth, Jøran, Åsberg, Anders, Jansson‐Löfmark, Rasmus, Christensen, Hege, Robertsen, Ida
Publicado 2022

Biology-Inspired Microphysiological Systems to Advance Patient Benefit and Animal Welfare in Drug Development

por Marx, Uwe, Akabane, Takafumi, Andersson, Tommy B., Baker, Elizabeth, Beilmann, Mario, Beken, Sonja, Brendler-Schwaab, Susanne, Cirit, Murat, David, Rhiannon, Dehne, Eva-Maria, Durieux, Isabell, Ewart, Lorna, Fitzpatrick, Suzanne C., Frey, Olivier, Fuchs, Florian, Griffith, Linda G., Hamilton, Geraldine A., Hartung, Thomas, Hoeng, Julia, Hogberg, Helena, Hughes, David J., Ingber, Donald E., Iskandar, Anita, Kanamori, Toshiyuki, Kojima, Hajime, Kuehnl, Jochen, Leist, Marcel, Li, Bo, Loskill, Peter, Mendrick, Donna L., Neumann, Thomas, Pallocca, Giorgia, Rusyn, Ivan, Smirnova, Lena, Steger-Hartmann, Thomas, Tagle, Danilo A., Tonevitsky, Alexander, Tsyb, Sergej, Trapecar, Martin, van de Water, Bob, van den Eijnden-van Raaij, Janny, Vulto, Paul, Watanabe, Kengo, Wolf, Armin, Zhou, Xiaobing, Roth, Adrian
Publicado 2020