Mutant Huntingtin Does Not Affect the Intrinsic Phenotype of Human Huntington’s Disease T Lymphocytes

por Miller, James R. C., Träger, Ulrike, Andre, Ralph, Tabrizi, Sarah J.
Publicado 2015

Wild-type huntingtin regulates human macrophage function

por O’Regan, Grace C., Farag, Sahar H., Ostroff, Gary R., Tabrizi, Sarah J., Andre, Ralph
Publicado 2020

In vivo neutralization of the protagonist role of macrophages during the chronic inflammatory stage of Huntington’s disease

por Pido-Lopez, Jeffrey, Andre, Ralph, Benjamin, Agnesska C., Ali, Nadira, Farag, Sahar, Tabrizi, Sarah J., Bates, Gillian P.
Publicado 2018

Inhibition of tumour necrosis factor alpha in the R6/2 mouse model of Huntington’s disease by etanercept treatment

por Pido-Lopez, Jeffrey, Tanudjojo, Benedict, Farag, Sahar, Bondulich, Marie-Katrin, Andre, Ralph, Tabrizi, Sarah J., Bates, Gillian P.
Publicado 2019

Human Huntington’s disease pluripotent stem cell-derived microglia develop normally but are abnormally hyper-reactive and release elevated levels of reactive oxygen species

por O’Regan, Grace C., Farag, Sahar H., Casey, Caroline S., Wood-Kaczmar, Alison, Pocock, Jennifer M., Tabrizi, Sarah J., Andre, Ralph
Publicado 2021

Prion-mediated neurodegeneration is associated with early impairment of the ubiquitin–proteasome system

por McKinnon, Chris, Goold, Rob, Andre, Ralph, Devoy, Anny, Ortega, Zaira, Moonga, Julie, Linehan, Jacqueline M., Brandner, Sebastian, Lucas, José J., Collinge, John, Tabrizi, Sarah J.
Publicado 2015

FAN1 modifies Huntington’s disease progression by stabilizing the expanded HTT CAG repeat

por Goold, Robert, Flower, Michael, Moss, Davina Hensman, Medway, Chris, Wood-Kaczmar, Alison, Andre, Ralph, Farshim, Pamela, Bates, Gill P, Holmans, Peter, Jones, Lesley, Tabrizi, Sarah J
Publicado 2019

Mislocalization of Nucleocytoplasmic Transport Proteins in Human Huntington’s Disease PSC-Derived Striatal Neurons

por Lange, Jenny, Wood-Kaczmar, Alison, Ali, Aneesa, Farag, Sahar, Ghosh, Rhia, Parker, Jennifer, Casey, Caroline, Uno, Yumiko, Kunugi, Akiyoshi, Ferretti, Patrizia, Andre, Ralph, Tabrizi, Sarah J.
Publicado 2021

Development of an ELISA assay for the quantification of soluble huntingtin in human blood cells

por Massai, Luisa, Petricca, Lara, Magnoni, Letizia, Rovetini, Luca, Haider, Salman, Andre, Ralph, Tabrizi, Sarah J, Süssmuth, Sigurd D, Landwehrmeyer, Bernhard G, Caricasole, Andrea, Pollio, Giuseppe, Bernocco, Simonetta
Publicado 2013

RNA-Seq of Huntington’s disease patient myeloid cells reveals innate transcriptional dysregulation associated with proinflammatory pathway activation

por Miller, James R. C., Lo, Kitty K., Andre, Ralph, Hensman Moss, Davina J., Träger, Ulrike, Stone, Timothy C., Jones, Lesley, Holmans, Peter, Plagnol, Vincent, Tabrizi, Sarah J.
Publicado 2016

Allele-Selective Suppression of Mutant Huntingtin in Primary Human Blood Cells

por Miller, James R. C., Pfister, Edith L., Liu, Wanzhao, Andre, Ralph, Träger, Ulrike, Kennington, Lori A., Lo, Kimberly, Dijkstra, Sipke, Macdonald, Douglas, Ostroff, Gary, Aronin, Neil, Tabrizi, Sarah J.
Publicado 2017

Characterisation of immune cell function in fragment and full-length Huntington's disease mouse models

por Träger, Ulrike, Andre, Ralph, Magnusson-Lind, Anna, Miller, James R.C., Connolly, Colúm, Weiss, Andreas, Grueninger, Stephan, Silajdžić, Edina, Smith, Donna L., Leavitt, Blair R., Bates, Gillian P., Björkqvist, Maria, Tabrizi, Sarah J.
Publicado 2015

Expression of mutant exon 1 huntingtin fragments in human neural stem cells and neurons causes inclusion formation and mitochondrial dysfunction

por Ghosh, Rhia, Wood‐Kaczmar, Alison, Dobson, Lucianne, Smith, Edward J., Sirinathsinghji, Eva C., Kriston‐Vizi, Janos, Hargreaves, Iain P., Heaton, Robert, Herrmann, Frank, Abramov, Andrey Y., Lam, Amanda J., Heales, Simon J., Ketteler, Robin, Bates, Gillian P., Andre, Ralph, Tabrizi, Sarah J.
Publicado 2020

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

por Björkqvist, Maria, Wild, Edward J., Thiele, Jenny, Silvestroni, Aurelio, Andre, Ralph, Lahiri, Nayana, Raibon, Elsa, Lee, Richard V., Benn, Caroline L., Soulet, Denis, Magnusson, Anna, Woodman, Ben, Landles, Christian, Pouladi, Mahmoud A., Hayden, Michael R., Khalili-Shirazi, Azadeh, Lowdell, Mark W., Brundin, Patrik, Bates, Gillian P., Leavitt, Blair R., Möller, Thomas, Tabrizi, Sarah J.
Publicado 2008