Biophysical Mapping of the Adenosine A(2A) Receptor

por Zhukov, Andrei, Andrews, Stephen P., Errey, James C., Robertson, Nathan, Tehan, Benjamin, Mason, Jonathan S., Marshall, Fiona H., Weir, Malcolm, Congreve, Miles
Publicado 2011

Identification of ARUK2002821 as an isoform-selective PI5P4Kα inhibitor

por Willems, Henriëtte M. G., Edwards, Simon, Boffey, Helen K., Chawner, Stephen J., Green, Christopher, Romero, Tamara, Winpenny, David, Skidmore, John, Clarke, Jonathan H., Andrews, Stephen P.
Publicado 2023

The rational design of ARUK2007145, a dual inhibitor of the α and γ isoforms of the lipid kinase phosphatidylinositol 5-phosphate 4-kinase (PI5P4K)

por Aldred, Gregory G., Rooney, Timothy P. C., Willems, Henriette M. G., Boffey, Helen K., Green, Christopher, Winpenny, David, Skidmore, John, Clarke, Jonathan H., Andrews, Stephen P.
Publicado 2023

Identification of Novel Adenosine A(2A) Receptor Antagonists by Virtual Screening

por Langmead, Christopher J., Andrews, Stephen P., Congreve, Miles, Errey, James C., Hurrell, Edward, Marshall, Fiona H., Mason, Jonathan S., Richardson, Christine M., Robertson, Nathan, Zhukov, Andrei, Weir, Malcolm
Publicado 2012

Discovery of 1,2,4-Triazine Derivatives as Adenosine A(2A) Antagonists using Structure Based Drug Design

por Congreve, Miles, Andrews, Stephen P., Doré, Andrew S., Hollenstein, Kaspar, Hurrell, Edward, Langmead, Christopher J., Mason, Jonathan S., Ng, Irene W., Tehan, Benjamin, Zhukov, Andrei, Weir, Malcolm, Marshall, Fiona H.
Publicado 2012

The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules

por Rooney, Timothy P. C., Aldred, Gregory G., Boffey, Helen K., Willems, Henriëtte M. G., Edwards, Simon, Chawner, Stephen J., Scott, Duncan E., Green, Christopher, Winpenny, David, Skidmore, John, Clarke, Jonathan H., Andrews, Stephen P.
Publicado 2022

Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase γ Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode

por Boffey, Helen K., Rooney, Timothy P. C., Willems, Henriette M. G., Edwards, Simon, Green, Christopher, Howard, Tina, Ogg, Derek, Romero, Tamara, Scott, Duncan E., Winpenny, David, Duce, James, Skidmore, John, Clarke, Jonathan H., Andrews, Stephen P.
Publicado 2022