Using Cryopreserved Plasmodium falciparum Sporozoites in a Humanized Mouse Model to Study Early Malaria Infection Processes and Test Prophylactic Treatments

por Jiménez-Díaz, María-Belén, Möhrle, Jörg J., Angulo-Barturen, Iñigo, Demarta-Gatsi, Claudia
Publicado 2023

The multistate tuberculosis pharmacometric model: a semi-mechanistic pharmacokinetic-pharmacodynamic model for studying drug effects in an acute tuberculosis mouse model

por Chen, Chunli, Ortega, Fatima, Rullas, Joaquin, Alameda, Laura, Angulo-Barturen, Iñigo, Ferrer, Santiago, Simonsson, Ulrika SH
Publicado 2017

Pharmacokinetic / pharmacodynamic relationships of liposomal amphotericin B and miltefosine in experimental visceral leishmaniasis

por Voak, Andrew A., Harris, Andy, Coteron-Lopez, Jose Miguel, Angulo-Barturen, Iñigo, Ferrer-Bazaga, Santiago, Croft, Simon L., Seifert, Karin
Publicado 2021

Enzyme Therapy: Current Challenges and Future Perspectives

por de la Fuente, Miguel, Lombardero, Laura, Gómez-González, Alfonso, Solari, Cristina, Angulo-Barturen, Iñigo, Acera, Arantxa, Vecino, Elena, Astigarraga, Egoitz, Barreda-Gómez, Gabriel
Publicado 2021

Identifying rapidly parasiticidal anti-malarial drugs using a simple and reliable in vitro parasite viability fast assay

por Linares, María, Viera, Sara, Crespo, Benigno, Franco, Virginia, Gómez-Lorenzo, María G., Jiménez-Díaz, María Belén, Angulo-Barturen, Íñigo, Sanz, Laura María, Gamo, Francisco-Javier
Publicado 2015

Combinations of β-Lactam Antibiotics Currently in Clinical Trials Are Efficacious in a DHP-I-Deficient Mouse Model of Tuberculosis Infection

por Rullas, Joaquín, Dhar, Neeraj, McKinney, John D., García-Pérez, Adolfo, Lelievre, Joël, Diacon, Andreas H., Hugonnet, Jean-Emmanuel, Arthur, Michel, Angulo-Barturen, Iñigo, Barros-Aguirre, David, Ballell, Lluís
Publicado 2015

Study of Tissue-Specific Reactive Oxygen Species Formation by Cell Membrane Microarrays for the Characterization of Bioactive Compounds

por Elexpe, Ane, Nieto, Nerea, Fernández-Cuétara, Claudia, Domínguez-Fernández, Celtia, Morera-Herreras, Teresa, Torrecilla, María, Miguélez, Cristina, Laso, Antonio, Ochoa, Eneko, Bailen, María, González-Coloma, Azucena, Angulo-Barturen, Iñigo, Astigarraga, Egoitz, Barreda-Gómez, Gabriel
Publicado 2021

A Murine Model of falciparum-Malaria by In Vivo Selection of Competent Strains in Non-Myelodepleted Mice Engrafted with Human Erythrocytes

por Angulo-Barturen, Iñigo, Jiménez-Díaz, María Belén, Mulet, Teresa, Rullas, Joaquín, Herreros, Esperanza, Ferrer, Santiago, Jiménez, Elena, Mendoza, Alfonso, Regadera, Javier, Rosenthal, Philip J., Bathurst, Ian, Pompliano, David L., Gómez de las Heras, Federico, Gargallo-Viola, Domingo
Publicado 2008

Macrocyclic Peptidomimetic Plasmepsin X Inhibitors with Potent In Vitro and In Vivo Antimalarial Activity

por Kovada, Vadims, Withers-Martinez, Chrislaine, Bobrovs, Raitis, Ce̅rule, Hele̅na, Liepins, Edgars, Grinberga, Solveiga, Hackett, Fiona, Collins, Christine R., Kreicberga, Agrita, Jiménez-Díaz, María Belén, Angulo-Barturen, Iñigo, Rasina, Dace, Suna, Edgars, Jaudzems, Kristaps, Blackman, Michael J., Jirgensons, Aigars
Publicado 2023

Chemoprotective Antimalarial Activity of P218 against Plasmodium falciparum: A Randomized, Placebo-Controlled Volunteer Infection Study

por Chughlay, Mohamed Farouk, El Gaaloul, Myriam, Donini, Cristina, Campo, Brice, Berghmans, Pieter-Jan, Lucardie, Alexander, Marx, Michael W., Cherkaoui-Rbati, Mohammed H., Langdon, Grant, Angulo-Barturen, Iñigo, Viera, Sara, Rosanas-Urgell, Anna, Van Geertruyden, Jean-Pierre, Chalon, Stephan
Publicado 2021

Repositioning: the fast track to new anti-malarial medicines?

por Lotharius, Julie, Gamo-Benito, Francisco Javier, Angulo-Barturen, Iñigo, Clark, Julie, Connelly, Michele, Ferrer-Bazaga, Santiago, Parkinson, Tanya, Viswanath, Pavithra, Bandodkar, Balachandra, Rautela, Nikhil, Bharath, Sowmya, Duffy, Sandra, Avery, Vicky M, Möhrle, Jörg J, Guy, R Kiplin, Wells, Timothy
Publicado 2014

Predicting Optimal Antimalarial Drug Combinations from a Standardized Plasmodium falciparum Humanized Mouse Model

por Demarta-Gatsi, Claudia, Andenmatten, Nicole, Jiménez-Díaz, María-Belén, Gobeau, Nathalie, Cherkaoui-Rabti, Mohammed H., Fuchs, Aline, Díaz, Pablo, Berja, Sandra, Sánchez, Rebeca, Gómez, Hazel, Ruiz, Estíbaliz, Sainz, Paula, Salazar, Eider, Gil-Merino, Rodrigo, Mendoza, Luis Manuel, Eguizabal, Cristina, Leroy, Didier, Moehrle, Joerg J., Tornesi, Belen, Angulo-Barturen, Iñigo
Publicado 2023

A New In Vivo Screening Paradigm to Accelerate Antimalarial Drug Discovery

por Jiménez-Díaz, María Belén, Viera, Sara, Ibáñez, Javier, Mulet, Teresa, Magán-Marchal, Noemí, Garuti, Helen, Gómez, Vanessa, Cortés-Gil, Lorena, Martínez, Antonio, Ferrer, Santiago, Fraile, María Teresa, Calderón, Félix, Fernández, Esther, Shultz, Leonard D., Leroy, Didier, Wilson, David M., García-Bustos, José Francisco, Gamo, Francisco Javier, Angulo-Barturen, Iñigo
Publicado 2013

Linking Murine and Human Plasmodium falciparum Challenge Models in a Translational Path for Antimalarial Drug Development

por McCarthy, James S., Marquart, Louise, Sekuloski, Silvana, Trenholme, Katharine, Elliott, Suzanne, Griffin, Paul, Rockett, Rebecca, O'Rourke, Peter, Sloots, Theo, Angulo-Barturen, Iñigo, Ferrer, Santiago, Jiménez-Díaz, María Belén, Martínez, María-Santos, van Huijsduijnen, Rob Hooft, Duparc, Stephan, Leroy, Didier, Wells, Timothy N. C., Baker, Mark, Möhrle, Jörg J.
Publicado 2016

A novel class of fast‐acting antimalarial agents: Substituted 15‐membered azalides

por Peric, Mihaela, Pešić, Dijana, Alihodžić, Sulejman, Fajdetić, Andrea, Herreros, Esperanza, Gamo, Francisco Javier, Angulo‐Barturen, Iñigo, Jiménez‐Díaz, María Belén, Ferrer‐Bazaga, Santiago, Martínez, María S., Gargallo‐Viola, Domingo, Mathis, Amanda, Kessler, Albane, Banjanac, Mihailo, Padovan, Jasna, Bencetić Mihaljević, Vlatka, Munic Kos, Vesna, Bukvić, Mirjana, Eraković Haber, Vesna, Spaventi, Radan
Publicado 2020

Determination of the Pharmacokinetics and Pharmacodynamics of Isoniazid, Rifampicin, Pyrazinamide and Ethambutol in a Cross-Over Cynomolgus Macaque Model of Mycobacterium tuberculo...

por Sibley, Laura, White, Andrew D., Sarfas, Charlotte, Gullick, Jennie, Gleeson, Fergus, Lanni, Faye, Clark, Simon, Rayner, Emma, Ferrer-Bazaga, Santiago, Ortega-Muro, Fatima, Alameda, Laura, Rullas, Joaquin, Sousa, Veronica, Martinez, Marisa, Angulo-Barturen, Inigo, Garcia, Adolfo, Vaquero, Juan José, Pertinez, Henry E., Davies, Geraint, Dennis, Mike, Williams, Ann, Sharpe, Sally
Publicado 2022

A Plasmodium berghei sporozoite-based vaccination platform against human malaria

por Mendes, António M., Machado, Marta, Gonçalves-Rosa, Nataniel, Reuling, Isaie J., Foquet, Lander, Marques, Cláudia, Salman, Ahmed M., Yang, Annie S. P., Moser, Kara A., Dwivedi, Ankit, Hermsen, Cornelus C., Jiménez-Díaz, Belén, Viera, Sara, Santos, Jorge M., Albuquerque, Inês, Bhatia, Sangeeta N., Bial, John, Angulo-Barturen, Iñigo, Silva, Joana C., Leroux-Roels, Geert, Janse, Chris J., Khan, Shahid M., Mota, Maria M., Sauerwein, Robert W., Prudêncio, Miguel
Publicado 2018

Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6′,7′-Dihydrospiro[Piperidine-4,4′-Thieno[3,2-c]Pyran] Analogues with Bactericidal Efficacy against Mycobacterium tub...

por Remuiñán, Modesto J., Pérez-Herrán, Esther, Rullás, Joaquín, Alemparte, Carlos, Martínez-Hoyos, María, Dow, David J., Afari, Johnson, Mehta, Nalini, Esquivias, Jorge, Jiménez, Elena, Ortega-Muro, Fátima, Fraile-Gabaldón, María Teresa, Spivey, Vickey L., Loman, Nicholas J., Pallen, Mark J., Constantinidou, Chrystala, Minick, Douglas J., Cacho, Mónica, Rebollo-López, María José, González, Carolina, Sousa, Verónica, Angulo-Barturen, Iñigo, Mendoza-Losana, Alfonso, Barros, David, Besra, Gurdyal S., Ballell, Lluís, Cammack, Nicholas
Publicado 2013

Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity

por Kokkonda, Sreekanth, Deng, Xiaoyi, White, Karen L., Coteron, Jose M., Marco, Maria, de las Heras, Laura, White, John, El Mazouni, Farah, Tomchick, Diana R., Manjalanagara, Krishne, Rudra, Kakali Rani, Chen, Gong, Morizzi, Julia, Ryan, Eileen, Kaminsky, Werner, Leroy, Didier, Martínez-Martínez, María Santos, Jimenez-Diaz, Maria Belen, Bazaga, Santiago Ferrer, Angulo-Barturen, Iñigo, Waterson, David, Burrows, Jeremy N., Matthews, Dave, Charman, Susan A., Phillips, Margaret A., Rathod, Pradipsinh K.
Publicado 2016

Pyrazoleamide compounds are potent antimalarials that target Na(+) homeostasis in intraerythrocytic Plasmodium falciparum

por Vaidya, Akhil B., Morrisey, Joanne M., Zhang, Zhongsheng, Das, Sudipta, Daly, Thomas M., Otto, Thomas D., Spillman, Natalie J., Wyvratt, Matthew, Siegl, Peter, Marfurt, Jutta, Wirjanata, Grennady, Sebayang, Boni F., Price, Ric N., Chatterjee, Arnab, Nagle, Advait, Stasiak, Marcin, Charman, Susan A., Angulo-Barturen, Iñigo, Ferrer, Santiago, Belén Jiménez-Díaz, María, Martínez, María Santos, Gamo, Francisco Javier, Avery, Vicky M., Ruecker, Andrea, Delves, Michael, Kirk, Kiaran, Berriman, Matthew, Kortagere, Sandhya, Burrows, Jeremy, Fan, Erkang, Bergman, Lawrence W.
Publicado 2014