The Catalytic Cycle of the Antioxidant and Cancer-Associated Human NQO1 Enzyme: Hydride Transfer, Conformational Dynamics and Functional Cooperativity

por Anoz-Carbonell, Ernesto, Timson, David J., Pey, Angel L., Medina, Milagros
Publicado 2020

Cofactors and pathogens: Flavin mononucleotide and flavin adenine dinucleotide (FAD) biosynthesis by the FAD synthase from Brucella ovis

por Moreno, Andrea, Taleb, Victor, Sebastián, María, Anoz‐Carbonell, Ernesto, Martínez‐Júlvez, Marta, Medina, Milagros
Publicado 2021

A Natural Chimeric Pseudomonas Bacteriocin with Novel Pore-Forming Activity Parasitizes the Ferrichrome Transporter

por Ghequire, Maarten G. K., Kemland, Lieselore, Anoz-Carbonell, Ernesto, Buchanan, Susan K., De Mot, René
Publicado 2017

Mutation of Aspartate 238 in FAD Synthase Isoform 6 Increases the Specific Activity by Weakening the FAD Binding

por Leone, Piero, Galluccio, Michele, Quarta, Stefano, Anoz-Carbonell, Ernesto, Medina, Milagros, Indiveri, Cesare, Barile, Maria
Publicado 2019

In silico discovery and biological validation of ligands of FAD synthase, a promising new antimicrobial target

por Lans, Isaias, Anoz-Carbonell, Ernesto, Palacio-Rodríguez, Karen, Aínsa, José Antonio, Medina, Milagros, Cossio, Pilar
Publicado 2020

Discovery of antimicrobial compounds targeting bacterial type FAD synthetases

por Sebastián, María, Anoz-Carbonell, Ernesto, Gracia, Begoña, Cossio, Pilar, Aínsa, José Antonio, Lans, Isaías, Medina, Milagros
Publicado 2017

Mycobacterial Aminoglycoside Acetyltransferases: A Little of Drug Resistance, and a Lot of Other Roles

por Sanz-García, Fernando, Anoz-Carbonell, Ernesto, Pérez-Herrán, Esther, Martín, Carlos, Lucía, Ainhoa, Rodrigues, Liliana, Aínsa, José A.
Publicado 2019

Targeting HIF-1α Function in Cancer through the Chaperone Action of NQO1: Implications of Genetic Diversity of NQO1

por Salido, Eduardo, Timson, David J., Betancor-Fernández, Isabel, Palomino-Morales, Rogelio, Anoz-Carbonell, Ernesto, Pacheco-García, Juan Luis, Medina, Milagros, Pey, Angel L.
Publicado 2022

Allosteric Communication in the Multifunctional and Redox NQO1 Protein Studied by Cavity-Making Mutations

por Pacheco-Garcia, Juan Luis, Loginov, Dmitry S., Anoz-Carbonell, Ernesto, Vankova, Pavla, Palomino-Morales, Rogelio, Salido, Eduardo, Man, Petr, Medina, Milagros, Naganathan, Athi N., Pey, Angel L.
Publicado 2022

A Novel Natural Siderophore Antibiotic Conjugate Reveals a Chemical Approach to Macromolecule Coupling

por Caradec, Thibault, Anoz-Carbonell, Ernesto, Petrov, Ravil, Billamboz, Muriel, Antraygues, Kevin, Cantrelle, Francois-Xavier, Boll, Emmanuelle, Beury, Delphine, Hot, David, Drobecq, Herve, Trivelli, Xavier, Hartkoorn, Ruben C.
Publicado 2023

Structural basis of the pleiotropic and specific phenotypic consequences of missense mutations in the multifunctional NAD(P)H:quinone oxidoreductase 1 and their pharmacological res...

por Pacheco-Garcia, Juan Luis, Anoz-Carbonell, Ernesto, Vankova, Pavla, Kannan, Adithi, Palomino-Morales, Rogelio, Mesa-Torres, Noel, Salido, Eduardo, Man, Petr, Medina, Milagros, Naganathan, Athi N., Pey, Angel L.
Publicado 2021

Selective Targeting of Human and Animal Pathogens of the Helicobacter Genus by Flavodoxin Inhibitors: Efficacy, Synergy, Resistance and Mechanistic Studies

por Salillas, Sandra, Galano-Frutos, Juan José, Mahía, Alejandro, Maity, Ritwik, Conde-Giménez, María, Anoz-Carbonell, Ernesto, Berlamont, Helena, Velazquez-Campoy, Adrian, Touati, Eliette, Mamat, Uwe, Schaible, Ulrich E., Gálvez, José A., Díaz-de-Villegas, María D., Haesebrouck, Freddy, Aínsa, José A., Sancho, Javier
Publicado 2021