Monocyclic β-Lactams Are Selective, Mechanism-Based Inhibitors of Rhomboid Intramembrane Proteases

por Pierrat, Olivier A., Strisovsky, Kvido, Christova, Yonka, Large, Jonathan, Ansell, Keith, Bouloc, Nathalie, Smiljanic, Ela, Freeman, Matthew
Publicado 2010

Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): Preparation and evaluation of pyrazole linked analogues()

por Large, Jonathan M., Osborne, Simon A., Smiljanic-Hurley, Ela, Ansell, Keith H., Jones, Hayley M., Taylor, Debra L., Clough, Barbara, Green, Judith L., Holder, Anthony A.
Publicado 2013

Corrigendum to “Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): Preparation and evaluation of pyrazole linked analogu...

por Large, Jonathan M., Osborne, Simon A., Smiljanic-Hurley, Ela, Ansell, Keith H., Jones, Hayley M., Taylor, Debra L., Clough, Barbara, Green, Judith L., Holder, Anthony A.
Publicado 2014

Optimization of an Imidazopyridazine Series of Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 (PfCDPK1)

por Chapman, Timothy M., Osborne, Simon A., Wallace, Claire, Birchall, Kristian, Bouloc, Nathalie, Jones, Hayley M., Ansell, Keith H., Taylor, Debra L., Clough, Barbara, Green, Judith L., Holder, Anthony A.
Publicado 2014

Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1)

por Chapman, Timothy M., Osborne, Simon A., Bouloc, Nathalie, Large, Jonathan M., Wallace, Claire, Birchall, Kristian, Ansell, Keith H., Jones, Hayley M., Taylor, Debra, Clough, Barbara, Green, Judith L., Holder, Anthony A.
Publicado 2013

Potent inhibitors of malarial P. Falciparum protein kinase G: Improving the cell activity of a series of imidazopyridines

por Large, Jonathan M., Birchall, Kristian, Bouloc, Nathalie S., Merritt, Andy T., Smiljanic-Hurley, Ela, Tsagris, Denise J., Wheldon, Mary C., Ansell, Keith H., Coombs, Peter J., Kettleborough, Catherine A., Whalley, David, Stewart, Lindsay B., Bowyer, Paul W., Baker, David A., Osborne, Simon A.
Publicado 2019

Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty

por Large, Jonathan M., Birchall, Kristian, Bouloc, Nathalie S., Merritt, Andy T., Smiljanic-Hurley, Ela, Tsagris, Denise J., Wheldon, Mary C., Ansell, Keith H., Coombs, Peter J., Kettleborough, Catherine A., Whalley, David, Stewart, Lindsay B., Bowyer, Paul W., Baker, David A., Osborne, Simon A.
Publicado 2019

Biochemical and Antiparasitic Properties of Inhibitors of the Plasmodium falciparum Calcium-Dependent Protein Kinase PfCDPK1

por Ansell, Keith H., Jones, Hayley M., Whalley, David, Hearn, Alisdair, Taylor, Debra L., Patin, Emmanuel C., Chapman, Timothy M., Osborne, Simon A., Wallace, Claire, Birchall, Kristian, Large, Jonathan, Bouloc, Nathalie, Smiljanic-Hurley, Ela, Clough, Barbara, Moon, Robert W., Green, Judith L., Holder, Anthony A.
Publicado 2014

Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Paras...

por Green, Judith L., Moon, Robert W., Whalley, David, Bowyer, Paul W., Wallace, Claire, Rochani, Ankit, Nageshan, Rishi K., Howell, Steven A., Grainger, Munira, Jones, Hayley M., Ansell, Keith H., Chapman, Timothy M., Taylor, Debra L., Osborne, Simon A., Baker, David A., Tatu, Utpal, Holder, Anthony A.
Publicado 2016

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission

por Baker, David A., Stewart, Lindsay B., Large, Jonathan M., Bowyer, Paul W., Ansell, Keith H., Jiménez-Díaz, María B., El Bakkouri, Majida, Birchall, Kristian, Dechering, Koen J., Bouloc, Nathalie S., Coombs, Peter J., Whalley, David, Harding, Denise J., Smiljanic-Hurley, Ela, Wheldon, Mary C., Walker, Eloise M., Dessens, Johannes T., Lafuente, María José, Sanz, Laura M., Gamo, Francisco-Javier, Ferrer, Santiago B., Hui, Raymond, Bousema, Teun, Angulo-Barturén, Iñigo, Merritt, Andy T., Croft, Simon L., Gutteridge, Winston E., Kettleborough, Catherine A., Osborne, Simon A.
Publicado 2017