Mechanism of Darunavir (DRV)’s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV...

por Aoki, Manabu, Das, Debananda, Hayashi, Hironori, Aoki-Ogata, Hiromi, Takamatsu, Yuki, Ghosh, Arun K., Mitsuya, Hiroaki
Publicado 2018

Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity

por Bulut, Haydar, Hattori, Shin-ichiro, Aoki-Ogata, Hiromi, Hayashi, Hironori, Das, Debananda, Aoki, Manabu, Davis, David A., Rao, Kalapala Venkateswara, Nyalapatla, Prasanth R., Ghosh, Arun K., Mitsuya, Hiroaki
Publicado 2020

GRL-142 binds to and impairs HIV-1 integrase nuclear localization signal and potently suppresses highly INSTI-resistant HIV-1 variants

por Aoki, Manabu, Aoki-Ogata, Hiromi, Bulut, Haydar, Hayashi, Hironori, Takamune, Nobutoki, Kishimoto, Naoki, Tanaka, Hiroki, Higashi-Kuwata, Nobuyo, Hattori, Shin-ichiro, Das, Debananda, Venkateswara Rao, Kalapala, Iwama, Kazuya, Davis, David A., Hasegawa, Kazuya, Murayama, Kazutaka, Yarchoan, Robert, Ghosh, Arun K., Pau, Alice K., Machida, Shinichi, Misumi, Shogo, Mitsuya, Hiroaki
Publicado 2023

A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency

por Aoki, Manabu, Hayashi, Hironori, Rao, Kalapala Venkateswara, Das, Debananda, Higashi-Kuwata, Nobuyo, Bulut, Haydar, Aoki-Ogata, Hiromi, Takamatsu, Yuki, Yedidi, Ravikiran S, Davis, David A, Hattori, Shin-ichiro, Nishida, Noriko, Hasegawa, Kazuya, Takamune, Nobutoki, Nyalapatla, Prasanth R, Osswald, Heather L, Jono, Hirofumi, Saito, Hideyuki, Yarchoan, Robert, Misumi, Shogo, Ghosh, Arun K, Mitsuya, Hiroaki
Publicado 2017