Mechanistic PK/PD modeling to address early-stage biotherapeutic dosing feasibility questions

por Grant, Joshuaine, Hua, Fei, Apgar, Joshua F., Burke, John M., Marcantonio, Diana H.
Publicado 2023

Stimulus Design for Model Selection and Validation in Cell Signaling

por Apgar, Joshua F, Toettcher, Jared E, Endy, Drew, White, Forest M, Tidor, Bruce
Publicado 2008

Quantitative systems pharmacology model of GITR‐mediated T cell dynamics in tumor microenvironment

por Ji, Yan, Madrasi, Kumpal, Knee, Deborah A., Gruenbaum, Lore, Apgar, Joshua F., Burke, John M., Gomes, Bruce
Publicado 2023

Quantitative Systems Pharmacology Model of a Masked, Tumor‐Activated Antibody

por Stroh, Mark, Sagert, Jason, Burke, John M., Apgar, Joshua F., Lin, Lin, Millard, Bjorn L., Michael Kavanaugh, W.
Publicado 2019

Early Feasibility Assessment: A Method for Accurately Predicting Biotherapeutic Dosing to Inform Early Drug Discovery Decisions

por Marcantonio, Diana H., Matteson, Andrew, Presler, Marc, Burke, John M., Hagen, David R., Hua, Fei, Apgar, Joshua F.
Publicado 2022

Quantitative systems toxicology

por Bloomingdale, Peter, Housand, Conrad, Apgar, Joshua F., Millard, Bjorn L., Mager, Donald E., Burke, John M., Shah, Dhaval K.
Publicado 2017

Virtual clinical trial simulations for a novel KRAS(G12C) inhibitor (ASP2453) in non‐small cell lung cancer

por Sayama, Hiroyuki, Marcantonio, Diana, Nagashima, Takeyuki, Shimazaki, Masashi, Minematsu, Tsuyoshi, Apgar, Joshua F, Burke, John M., Wille, Lucia, Nagasaka, Yasuhisa, Kirouac, Daniel C.
Publicado 2021

Quantitative systems pharmacology model for Alzheimer’s disease to predict the effect of aducanumab on brain amyloid

por Lin, Lin, Hua, Fei, Salinas, Cristian, Young, Carissa, Bussiere, Thierry, Apgar, Joshua F., Burke, John M., Kandadi Muralidharan, Kumar, Rajagovindan, Rajasimhan, Nestorov, Ivan
Publicado 2022

A systems pharmacology model for gene therapy in sickle cell disease

por Zheng, Bo, Wille, Lucia, Peppel, Karsten, Hagen, David, Matteson, Andrew, Ahlers, Jeffrey, Schaff, James, Hua, Fei, Yuraszeck, Theresa, Cobbina, Enoch, Apgar, Joshua F., Burke, John M., Roberts, John, Das, Raibatak
Publicado 2021

Systematic in silico analysis of clinically tested drugs for reducing amyloid‐beta plaque accumulation in Alzheimer's disease

por Madrasi, Kumpal, Das, Raibatak, Mohmmadabdul, Hafiz, Lin, Lin, Hyman, Bradley T., Lauffenburger, Douglas A., Albers, Mark W., Rissman, Robert A., Burke, John M., Apgar, Joshua F., Wille, Lucia, Gruenbaum, Lore, Hua, Fei
Publicado 2021

Quantitative Systems Pharmacology Model of hUGT1A1‐modRNA Encoding for the UGT1A1 Enzyme to Treat Crigler‐Najjar Syndrome Type 1

por Apgar, Joshua F., Tang, Jian‐Ping, Singh, Pratap, Balasubramanian, Nanda, Burke, John, Hodges, Michael R., Lasaro, Melissa A., Lin, Lin, Miliard, Bjorn L., Moore, Kristi, Jun, Lucy S., Sobolov, Susan, Wilkins, Anna Katharina, Gao, Xiang
Publicado 2018

Fibrinolytic therapy for refractory COVID‐19 acute respiratory distress syndrome: Scientific rationale and review

por Barrett, Christopher D., Moore, Hunter B., Moore, Ernest E., McIntyre, Robert C., Moore, Peter K., Burke, John, Hua, Fei, Apgar, Joshua, Talmor, Daniel S., Sauaia, Angela, Liptzin, Deborah R., Veress, Livia A., Yaffe, Michael B.
Publicado 2020