Development of and insights from systems pharmacology models of antibody‐drug conjugates

por Lam, Inez, Pilla Reddy, Venkatesh, Ball, Kathryn, Arends, Rosalinda H., Mac Gabhann, Feilim
Publicado 2022

Harnessing Clinical Trial and Real-World Data Towards an Understanding of Sex Effects on Drug Pharmacokinetics, Pharmacodynamics and Efficacy

por Oi Yan Chan, Joyce, Moullet, Marie, Williamson, Beth, Arends, Rosalinda H., Pilla Reddy, Venkatesh
Publicado 2022

Comparing the applications of machine learning, PBPK, and population pharmacokinetic models in pharmacokinetic drug–drug interaction prediction

por Gill, Jaidip, Moullet, Marie, Martinsson, Anton, Miljković, Filip, Williamson, Beth, Arends, Rosalinda H., Pilla Reddy, Venkatesh
Publicado 2022

Evaluating the performance of machine‐learning regression models for pharmacokinetic drug–drug interactions

por Gill, Jaidip, Moullet, Marie, Martinsson, Anton, Miljković, Filip, Williamson, Beth, Arends, Rosalinda H., Pilla Reddy, Venkatesh
Publicado 2022

Safety, Tolerability and Pharmacokinetics of Half-Life Extended Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Monoclonal Antibodies AZD7442 (Tixagevimab-Cilgavimab)...

por Forte-Soto, Pablo, Albayaty, Muna, Brooks, Dennis, Arends, Rosalinda H, Tillinghast, John, Aksyuk, Anastasia A, Bouquet, Jerome, Chen, Cecil, Gebre, Asfiha, Kubiak, Robert J, Pilla Reddy, Venkatesh, Seegobin, Seth, Streicher, Katie, Templeton, Alison, Esser, Mark T
Publicado 2023

Multiplex Hybrid Antigen-Capture LC-MRM Quantification in Sera and Nasal Lining Fluid of AZD7442, a SARS-CoV-2-Targeting Antibody Combination

por Mu, Ruipeng, Huang, Yue, Bouquet, Jerome, Yuan, Jiaqi, Kubiak, Robert J., Ma, Eric, Naser, Sami, Mylott, William R., Ismaiel, Omnia A., Wheeler, Aaron M., Burkart, Rebecca, Cortes, Diego F., Bruton, James, Arends, Rosalinda H., Liang, Meina, Rosenbaum, Anton I.
Publicado 2022

LB5. PROVENT: Phase 3 Study of Efficacy and Safety of AZD7442 (Tixagevimab/Cilgavimab) for Pre-exposure Prophylaxis of COVID-19 in Adults

por Levin, Myron J, Ustianowski, Andrew, De Wit, Stéphane, Launay, Odile, Avila, Miles, Seegobin, Seth, Templeton, Alison, Yuan, Yuan, Ambery, Philip, Arends, Rosalinda H, Beavon, Rohini, Near, Karen A, Padilla, Kelly W, Psachoulia, Konstantina, Sharbaugh, Audrey, Streicher, Katie, Pangalos, Menelas N, Esser, Mark T, Gasser, Robert A
Publicado 2021

AZD7442 (Tixagevimab/Cilgavimab) for Post-Exposure Prophylaxis of Symptomatic Coronavirus Disease 2019

por Levin, Myron J, Ustianowski, Andrew, Thomas, Steven, Templeton, Alison, Yuan, Yuan, Seegobin, Seth, Houlihan, Catherine F, Menendez-Perez, Ibrahim, Pollett, Simon, Arends, Rosalinda H, Beavon, Rohini, Dey, Kanika, Garbes, Pedro, Kelly, Elizabeth J, Koh, Gavin C K W, Ivanov, Stefan, Near, Karen A, Sharbaugh, Audrey, Streicher, Katie, Pangalos, Menelas N, Esser, Mark T
Publicado 2022

Efficacy and safety of intramuscular administration of tixagevimab–cilgavimab for early outpatient treatment of COVID-19 (TACKLE): a phase 3, randomised, double-blind, placebo-cont...

por Montgomery, Hugh, Hobbs, F D Richard, Padilla, Francisco, Arbetter, Douglas, Templeton, Alison, Seegobin, Seth, Kim, Kenneth, Campos, Jesus Abraham Simón, Arends, Rosalinda H, Brodek, Bryan H, Brooks, Dennis, Garbes, Pedro, Jimenez, Julieta, Koh, Gavin C K W, Padilla, Kelly W, Streicher, Katie, Viani, Rolando M, Alagappan, Vijay, Pangalos, Menelas N, Esser, Mark T
Publicado 2022

Intramuscular AZD7442 (Tixagevimab–Cilgavimab) for Prevention of Covid-19

por Levin, Myron J., Ustianowski, Andrew, De Wit, Stéphane, Launay, Odile, Avila, Miles, Templeton, Alison, Yuan, Yuan, Seegobin, Seth, Ellery, Adam, Levinson, Dennis J., Ambery, Philip, Arends, Rosalinda H., Beavon, Rohini, Dey, Kanika, Garbes, Pedro, Kelly, Elizabeth J., Koh, Gavin C.K.W., Near, Karen A., Padilla, Kelly W., Psachoulia, Konstantina, Sharbaugh, Audrey, Streicher, Katie, Pangalos, Menelas N., Esser, Mark T.
Publicado 2022

The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in non-human primates and has an extended half-life in humans

por Loo, Yueh-Ming, McTamney, Patrick M., Arends, Rosalinda H., Abram, Michael E., Aksyuk, Anastasia A., Diallo, Seme, Flores, Daniel J., Kelly, Elizabeth J., Ren, Kuishu, Roque, Richard, Rosenthal, Kim, Streicher, Katie, Tuffy, Kevin M., Bond, Nicholas J., Cornwell, Owen, Bouquet, Jerome, Cheng, Lily I., Dunyak, James, Huang, Yue, Rosenbaum, Anton I., Reddy, Venkatesh Pilla, Andersen, Hanne, Carnahan, Robert H., Crowe, James E., Kuehne, Ana I., Herbert, Andrew S., Dye, John M., Bright, Helen, Kallewaard, Nicole L., Pangalos, Menelas N., Esser, Mark T.
Publicado 2022