Autophagy Receptor-Inspired Antibody-Fusion Proteins for Targeted Intracellular Degradation

por Jiang, Ziwen, Kuo, Yu-Hsuan, Arkin, Michelle R.
Publicado 2023

Tethering in RNA: An RNA-Binding Fragment Discovery Tool

por Tran, Kiet, Arkin, Michelle R., Beal, Peter A.
Publicado 2015

p97 Disease Mutations Modulate Nucleotide-Induced Conformation to Alter Protein–Protein Interactions

por Bulfer, Stacie L., Chou, Tsui-Fen, Arkin, Michelle R.
Publicado 2016

LC3B Binds to the Autophagy Protease ATG4b with High Affinity Using a Bipartite Interface

por Tang, Yinyan, Kay, Amber, Jiang, Ziwen, Arkin, Michelle R.
Publicado 2022

Octopamine signaling in the metazoan pathogen Schistosoma mansoni: localization, small-molecule screening and opportunities for drug development

por El-Sakkary, Nelly, Chen, Steven, Arkin, Michelle R., Caffrey, Conor R., Ribeiro, Paula
Publicado 2018

A multi-dimensional, time-lapse, high content screening platform applied to schistosomiasis drug discovery

por Chen, Steven, Suzuki, Brian M., Dohrmann, Jakob, Singh, Rahul, Arkin, Michelle R., Caffrey, Conor R.
Publicado 2020

A Screen against Leishmania Intracellular Amastigotes: Comparison to a Promastigote Screen and Identification of a Host Cell-Specific Hit

por De Muylder, Geraldine, Ang, Kenny K. H., Chen, Steven, Arkin, Michelle R., Engel, Juan C., McKerrow, James H.
Publicado 2011

Novel Cruzain Inhibitors for the Treatment of Chagas’ Disease

por Rogers, Kathleen E, Keränen, Henrik, Durrant, Jacob D, Ratnam, Joseline, Doak, Allison, Arkin, Michelle R, McCammon, J Andrew
Publicado 2012

The p97/VCP adapter UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions

por Braxton, Julian R., Altobelli, Chad R., Tucker, Maxwell R., Tse, Eric, Thwin, Aye C., Arkin, Michelle R., Southworth, Daniel R.
Publicado 2023

Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERRγ Protein–Protein Interaction as a Molecular Glue Drug Discovery Approach

por Somsen, Bente A., Schellekens, Rick J.C., Verhoef, Carlo J.A., Arkin, Michelle R., Ottmann, Christian, Cossar, Peter J., Brunsveld, Luc
Publicado 2023

A High-Throughput Functional Screen Identifies Small Molecule Regulators of Temperature- and Mechano-Sensitive K(2P) Channels

por Bagriantsev, Sviatoslav N., Ang, Kean-Hooi, Gallardo-Godoy, Alejandra, Clark, Kimberly A., Arkin, Michelle R., Renslo, Adam R., Minor, Daniel L.
Publicado 2013

Fluorescence Anisotropy-Based Tethering for Discovery of Protein–Protein Interaction Stabilizers

por Sijbesma, Eline, Somsen, Bente A., Miley, Galen P., Leijten-van de Gevel, Iris A., Brunsveld, Luc, Arkin, Michelle R., Ottmann, Christian
Publicado 2020

Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers

por Sijbesma, Eline, Hallenbeck, Kenneth K., Andrei, Sebastian A., Rust, Reanne R., Adriaans, Joris M. C., Brunsveld, Luc, Arkin, Michelle R., Ottmann, Christian
Publicado 2021

Adaptor-Specific Antibody Fragment Inhibitors for the Intracellular Modulation of p97 (VCP) Protein–Protein Interactions

por Jiang, Ziwen, Kuo, Yu-Hsuan, Zhong, Mengqi, Zhang, Jianchao, Zhou, Xin X., Xing, Lijuan, Wells, James A., Wang, Yanzhuang, Arkin, Michelle R.
Publicado 2022

Functional Assessment of 2,177 U.S. and International Drugs Identifies the Quinoline Nitroxoline as a Potent Amoebicidal Agent against the Pathogen Balamuthia mandrillaris

por Laurie, Matthew T., White, Corin V., Retallack, Hanna, Wu, Wesley, Moser, Matthew S., Sakanari, Judy A., Ang, Kenny, Wilson, Christopher, Arkin, Michelle R., DeRisi, Joseph L.
Publicado 2018

Identification of Plasmodium dipeptidyl aminopeptidase allosteric inhibitors by high throughput screening

por Sanchez, Mateo I., de Vries, Laura E., Lehmann, Christine, Lee, Jeong T., Ang, Kenny K., Wilson, Christopher, Chen, Steven, Arkin, Michelle R., Bogyo, Matthew, Deu, Edgar
Publicado 2019

Phenotypic Screening Using High-Content Imaging to Identify Lysosomal pH Modulators in a Neuronal Cell Model

por Chin, Marcus Y., Ang, Kean-Hooi, Davies, Julia, Alquezar, Carolina, Garda, Virginia G., Rooney, Brendan, Leng, Kun, Kampmann, Martin, Arkin, Michelle R., Kao, Aimee W.
Publicado 2022

Voreloxin Is an Anticancer Quinolone Derivative that Intercalates DNA and Poisons Topoisomerase II

por Hawtin, Rachael E., Stockett, David E., Byl, Jo Ann W., McDowell, Robert S., Tan, Nguyen, Arkin, Michelle R., Conroy, Andrew, Yang, Wenjin, Osheroff, Neil, Fox, Judith A.
Publicado 2010

A Systematic Approach to the Discovery of Protein–Protein Interaction Stabilizers

por Kenanova, Dyana N., Visser, Emira J., Virta, Johanna M., Sijbesma, Eline, Centorrino, Federica, Vickery, Holly R., Zhong, Mengqi, Neitz, R. Jeffrey, Brunsveld, Luc, Ottmann, Christian, Arkin, Michelle R.
Publicado 2023

Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3σ/ERα Protein–Protein Interaction from Nonselective Fragments

por Konstantinidou, Markella, Visser, Emira J., Vandenboorn, Edmee, Chen, Sheng, Jaishankar, Priyadarshini, Overmans, Maurits, Dutta, Shubhankar, Neitz, R. Jeffrey, Renslo, Adam R., Ottmann, Christian, Brunsveld, Luc, Arkin, Michelle R.
Publicado 2023