To inhibit TrxR1 is to inactivate STAT3–Inhibition of TrxR1 enzymatic function by STAT3 small molecule inhibitors

por Busker, Sander, Page, Brent, Arnér, Elias S.J.
Publicado 2020

Qualitative Differences in Protection of PTP1B Activity by the Reductive Trx1 or TRP14 Enzyme Systems upon Oxidative Challenges with Polysulfides or H(2)O(2) Together with Bicarbon...

por Dagnell, Markus, Cheng, Qing, Arnér, Elias S.J.
Publicado 2021

Cell Death by SecTRAPs: Thioredoxin Reductase as a Prooxidant Killer of Cells

por Anestål, Karin, Prast-Nielsen, Stefanie, Cenas, Narimantas, Arnér, Elias S. J.
Publicado 2008

Time- and cell-resolved dynamics of redox-sensitive Nrf2, HIF and NF-κB activities in 3D spheroids enriched for cancer stem cells

por Kipp, Anna P., Deubel, Stefanie, Arnér, Elias S.J., Johansson, Katarina
Publicado 2017

Inhibition and crosslinking of the selenoprotein thioredoxin reductase-1 by p-benzoquinone

por Shu, Nan, Cheng, Qing, Arnér, Elias S.J., Davies, Michael J.
Publicado 2019

Biochemical Discrimination between Selenium and Sulfur 2: Mechanistic Investigation of the Selenium Specificity of Human Selenocysteine Lyase

por Johansson, Ann-Louise, Collins, Ruairi, Arnér, Elias S. J., Brzezinski, Peter, Högbom, Martin
Publicado 2012

Wobble decoding by the Escherichia coli selenocysteine insertion machinery

por Xu, Jianqiang, Croitoru, Victor, Rutishauser, Dorothea, Cheng, Qing, Arnér, Elias S.J.
Publicado 2013

Dietary methionine can sustain cytosolic redox homeostasis in the mouse liver

por Eriksson, Sofi, Prigge, Justin R., Talago, Emily A., Arnér, Elias S. J., Schmidt, Edward E.
Publicado 2015

Thioredoxin reductase 1 suppresses adipocyte differentiation and insulin responsiveness

por Peng, Xiaoxiao, Giménez-Cassina, Alfredo, Petrus, Paul, Conrad, Marcus, Rydén, Mikael, Arnér, Elias S. J.
Publicado 2016

Comprehensive chemical proteomics analyses reveal that the new TRi-1 and TRi-2 compounds are more specific thioredoxin reductase 1 inhibitors than auranofin

por Sabatier, Pierre, Beusch, Christian M., Gencheva, Radosveta, Cheng, Qing, Zubarev, Roman, Arnér, Elias S.J.
Publicado 2021

TXNL1 has dual functions as a redox active thioredoxin-like protein as well as an ATP- and redox-independent chaperone

por Andor, Attila, Mohanraj, Mahendravarman, Pató, Zsuzsanna Anna, Úri, Katalin, Biri-Kovács, Beáta, Cheng, Qing, Arnér, Elias S.J.
Publicado 2023

Cisplatin and oxaliplatin are toxic to cochlear outer hair cells and both target thioredoxin reductase in organ of Corti cultures

por Dammeyer, Pascal, Hellberg, Victoria, Wallin, Inger, Laurell, Göran, Shoshan, Maria, Ehrsson, Hans, Arnér, Elias S.J., Kirkegaard, Mette
Publicado 2014

Molecular Basis for the Interactions of Human Thioredoxins with Their Respective Reductases

por Hossain, Md Faruq, Bodnar, Yana, Klein, Calvin, Salas, Clara Ortegón, Arnér, Elias S. J., Gellert, Manuela, Lillig, Christopher Horst
Publicado 2021

Targeting of Nrf2 improves antitumoral responses by human NK cells, TIL and CAR T cells during oxidative stress

por Renken, Stefanie, Nakajima, Takahiro, Magalhaes, Isabelle, Mattsson, Jonas, Lundqvist, Andreas, Arnér, Elias S J, Kiessling, Rolf, Wickström, Stina Linnea
Publicado 2022

Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target

por Kuntz, Angela N, Davioud-Charvet, Elisabeth, Sayed, Ahmed A, Califf, Lindsay L, Dessolin, Jean, Arnér, Elias S. J, Williams, David L
Publicado 2007

Correction: Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target

por Kuntz, Angela N, Davioud-Charvet, Elisabeth, Sayed, Ahmed A, Califf, Lindsay L, Dessolin, Jean, Arnér, Elias S. J, Williams, David L
Publicado 2007

Development of an assay pipeline for the discovery of novel small molecule inhibitors of human glutathione peroxidases GPX1 and GPX4

por Cheff, Dorian M., Cheng, Qing, Guo, Hui, Travers, Jameson, Klumpp-Thomas, Carleen, Shen, Min, Arnér, Elias S.J., Hall, Matthew D.
Publicado 2023

Characterization of More Selective Central Nervous System Nrf2-Activating Novel Vinyl Sulfoximine Compounds Compared to Dimethyl Fumarate

por Carlström, Karl E., Chinthakindi, Praveen K., Espinosa, Belén, Al Nimer, Faiez, Arnér, Elias S. J., Arvidsson, Per I., Piehl, Fredrik, Johansson, Katarina
Publicado 2020

Evaluation of dithiothreitol-oxidizing capacity (DOC) as a serum biomarker for chronic hepatitis B in patients exhibiting normal alanine aminotransferase levels: a pilot study towa...

por Yang, Lumin, Zhang, Yafei, Zhang, Ke, Liu, Zhongping, He, Tengfei, Zheng, Xiaowei, Li, Lei, Arnér, Elias S J, Zhang, Zhenhua, Zhang, Jinsong
Publicado 2021

The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1

por Cheff, Dorian M., Huang, Chuying, Scholzen, Karoline C., Gencheva, Radosveta, Ronzetti, Michael H., Cheng, Qing, Hall, Matthew D., Arnér, Elias S.J.
Publicado 2023