To inhibit TrxR1 is to inactivate STAT3–Inhibition of TrxR1 enzymatic function by STAT3 small molecule inhibitors

por Busker, Sander, Page, Brent, Arnér, Elias S.J.
Publicado 2020

Qualitative Differences in Protection of PTP1B Activity by the Reductive Trx1 or TRP14 Enzyme Systems upon Oxidative Challenges with Polysulfides or H(2)O(2) Together with Bicarbon...

por Dagnell, Markus, Cheng, Qing, Arnér, Elias S.J.
Publicado 2021

Time- and cell-resolved dynamics of redox-sensitive Nrf2, HIF and NF-κB activities in 3D spheroids enriched for cancer stem cells

por Kipp, Anna P., Deubel, Stefanie, Arnér, Elias S.J., Johansson, Katarina
Publicado 2017

Inhibition and crosslinking of the selenoprotein thioredoxin reductase-1 by p-benzoquinone

por Shu, Nan, Cheng, Qing, Arnér, Elias S.J., Davies, Michael J.
Publicado 2019

Wobble decoding by the Escherichia coli selenocysteine insertion machinery

por Xu, Jianqiang, Croitoru, Victor, Rutishauser, Dorothea, Cheng, Qing, Arnér, Elias S.J.
Publicado 2013

Comprehensive chemical proteomics analyses reveal that the new TRi-1 and TRi-2 compounds are more specific thioredoxin reductase 1 inhibitors than auranofin

por Sabatier, Pierre, Beusch, Christian M., Gencheva, Radosveta, Cheng, Qing, Zubarev, Roman, Arnér, Elias S.J.
Publicado 2021

TXNL1 has dual functions as a redox active thioredoxin-like protein as well as an ATP- and redox-independent chaperone

por Andor, Attila, Mohanraj, Mahendravarman, Pató, Zsuzsanna Anna, Úri, Katalin, Biri-Kovács, Beáta, Cheng, Qing, Arnér, Elias S.J.
Publicado 2023

Cisplatin and oxaliplatin are toxic to cochlear outer hair cells and both target thioredoxin reductase in organ of Corti cultures

por Dammeyer, Pascal, Hellberg, Victoria, Wallin, Inger, Laurell, Göran, Shoshan, Maria, Ehrsson, Hans, Arnér, Elias S.J., Kirkegaard, Mette
Publicado 2014

Side-by-side comparison of recombinant human glutathione peroxidases identifies overlapping substrate specificities for soluble hydroperoxides

por Schwarz, Maria, Löser, Alina, Cheng, Qing, Wichmann-Costaganna, Mareike, Schädel, Patrick, Werz, Oliver, Arnér, Elias SJ., Kipp, Anna P.
Publicado 2023

Development of an assay pipeline for the discovery of novel small molecule inhibitors of human glutathione peroxidases GPX1 and GPX4

por Cheff, Dorian M., Cheng, Qing, Guo, Hui, Travers, Jameson, Klumpp-Thomas, Carleen, Shen, Min, Arnér, Elias S.J., Hall, Matthew D.
Publicado 2023

APR-246/PRIMA-1(MET) inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase

por Peng, Xiaoxiao, Zhang, Mei-Qiong-Zi, Conserva, Francesca, Hosny, Gihan, Selivanova, Galina, Bykov, Vladimir JN, Arnér, Elias SJ, Wiman, Klas G
Publicado 2017

The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1

por Cheff, Dorian M., Huang, Chuying, Scholzen, Karoline C., Gencheva, Radosveta, Ronzetti, Michael H., Cheng, Qing, Hall, Matthew D., Arnér, Elias S.J.
Publicado 2023

Arsenic exposure and increased C-reactive protein are independently associated with lower erythrocyte glutathione peroxidase activity in Bangladeshi children

por Cheff, Dorian M., Skröder, Helena, Akhtar, Evana, Cheng, Qing, Hall, Matthew D., Raqib, Rubhana, Kippler, Maria, Vahter, Marie, Arnér, Elias S.J.
Publicado 2023

Clozapine suppresses NADPH oxidase activation, counteracts cytosolic H(2)O(2), and triggers early onset mitochondrial dysfunction during adipogenesis of human liposarcoma SW872 cel...

por Blandino, Giulia, Fiorani, Mara, Canonico, Barbara, De Matteis, Rita, Guidarelli, Andrea, Montanari, Mariele, Buffi, Gloria, Coppo, Lucia, Arnér, Elias S.J., Cantoni, Orazio
Publicado 2023

Cytosolic thioredoxin reductase 1 is required for correct disulfide formation in the ER

por Poet, Greg J, Oka, Ojore BV, van Lith, Marcel, Cao, Zhenbo, Robinson, Philip J, Pringle, Marie Anne, Arnér, Elias SJ, Bulleid, Neil J
Publicado 2017

Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads

por Kaminska, Kamila K., Bertrand, Helene C., Tajima, Hisashi, Stafford, William C., Cheng, Qing, Chen, Wan, Wells, Geoffrey, Arner, Elias S.J., Chew, Eng-Hui
Publicado 2016

Comprehensive chemical proteomics for target deconvolution of the redox active drug auranofin

por Saei, Amir Ata, Gullberg, Hjalmar, Sabatier, Pierre, Beusch, Christian M., Johansson, Katarina, Lundgren, Bo, Arvidsson, Per I., Arnér, Elias S.J., Zubarev, Roman A.
Publicado 2020

Production and purification of homogenous recombinant human selenoproteins reveals a unique codon skipping event in E. coli and GPX4-specific affinity to bromosulfophthalein

por Cheng, Qing, Roveri, Antonella, Cozza, Giorgio, Bordin, Luciana, Rohn, Isabelle, Schwerdtle, Tanja, Kipp, Anna, Ursini, Fulvio, Maiorino, Matilde, Miotto, Giovanni, Arnér, Elias S.J.
Publicado 2021

Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells

por Sachweh, Marijke C.C., Stafford, William C., Drummond, Catherine J., McCarthy, Anna R., Higgins, Maureen, Campbell, Johanna, Brodin, Bertha, Arnér, Elias S.J., Laín, Sonia
Publicado 2015

Cardiolipin drives the catalytic activity of GPX4 on membranes: Insights from the R152H mutant

por Roveri, Antonella, Di Giacinto, Flavio, Rossetto, Monica, Cozza, Giorgio, Cheng, Qing, Miotto, Giovanni, Zennaro, Lucio, Di Paolo, Maria Luisa, Arnér, Elias S.J., De Spirito, Marco, Maiorino, Matilde, Ursini, Fulvio
Publicado 2023