Pharmacokinetic comparison of a diverse panel of non-targeting human antibodies as matched IgG1 and IgG2 isotypes in rodents and non-human primates

por Walker, Kenneth W., Salimi-Moosavi, Hossein, Arnold, Gregory E., Chen, Qing, Soto, Marcus, Jacobsen, Frederick W., Hui, John
Publicado 2019

Brief Report: A Randomized, Double‐Blind, Parallel‐Group, Placebo‐Controlled, Multiple‐Dose Study to Evaluate AMG 557 in Patients With Systemic Lupus Erythematosus and Active Lupus...

por Cheng, Laurence E., Amoura, Zahir, Cheah, Benjamin, Hiepe, Falk, Sullivan, Barbara A., Zhou, Lei, Arnold, Gregory E., Tsuji, Wayne H., Merrill, Joan T., Chung, James B.
Publicado 2018

Reduced TRPM8 expression underpins reduced migraine risk and attenuated cold pain sensation in humans

por Gavva, Narender R., Sandrock, Robert, Arnold, Gregory E., Davis, Michael, Lamas, Edwin, Lindvay, Chris, Li, Chi-Ming, Smith, Brian, Backonja, Miroslav, Gabriel, Kristin, Vargas, Gabriel
Publicado 2019

Brief Report: Pharmacodynamics, Safety, and Clinical Efficacy of AMG 811, a Human Anti–Interferon‐γ Antibody, in Patients With Discoid Lupus Erythematosus

por Werth, Victoria P., Fiorentino, David, Sullivan, Barbara A., Boedigheimer, Michael J., Chiu, Kit, Wang, Christine, Arnold, Gregory E., Damore, Michael A., Bigler, Jeannette, Welcher, Andrew A., Russell, Chris B., Martin, David A., Chung, James B.
Publicado 2017

Blockade of Interferon‐γ Normalizes Interferon‐Regulated Gene Expression and Serum CXCL10 Levels in Patients With Systemic Lupus Erythematosus

por Welcher, Andrew A., Boedigheimer, Michael, Kivitz, Alan J., Amoura, Zahir, Buyon, Jill, Rudinskaya, Alla, Latinis, Kevin, Chiu, Kit, Oliner, Kelly S., Damore, Michael A., Arnold, Gregory E., Sohn, Winnie, Chirmule, Narendra, Goyal, Lovely, Banfield, Christopher, Chung, James B.
Publicado 2015

Safety, pharmacokinetics and pharmacodynamics of AMG 811, an anti-interferon-γ monoclonal antibody, in SLE subjects without or with lupus nephritis

por Boedigheimer, Michael J, Martin, David A, Amoura, Zahir, Sánchez-Guerrero, Jorge, Romero-Diaz, Juanita, Kivitz, Alan, Aranow, Cynthia, Chan, Tak Mao, Chong, Yip Boon, Chiu, Kit, Wang, Christine, Sohn, Winnie, Arnold, Gregory E, Damore, Michael A, Welcher, Andrew A, Sullivan, Barbara A, Kotzin, Brian L, Chung, James B
Publicado 2017