Hydroxychloroquine for Treatment of SARS‐CoV‐2 Infection? Improving Our Confidence in a Model‐Based Approach to Dose Selection

por Arnold, Samuel L.M., Buckner, Frederick
Publicado 2020

Evaluation of in vitro and in vivo antibiotic efficacy against a novel bioluminescent Shigella flexneri

por McCloskey, Molly C., Shaheen, Shareef, Rabago, Lesley, Hulverson, Matthew A., Choi, Ryan, Barrett, Lynn K., Arnold, Samuel L. M.
Publicado 2019

Author Correction: Evaluation of in vitro and in vivo antibiotic efficacy against a novel bioluminescent Shigella flexneri

por McCloskey, Molly C., Shaheen, Shareef, Rabago, Lesley, Hulverson, Matthew A., Choi, Ryan, Barrett, Lynn K., Arnold, Samuel L. M.
Publicado 2020

Impact of confinement housing on study end-points in the calf model of cryptosporidiosis

por Graef, Geneva, Hurst, Natalie J., Kidder, Lance, Sy, Tracy L., Goodman, Laura B., Preston, Whitney D., Arnold, Samuel L. M., Zambriski, Jennifer A.
Publicado 2018

P-Glycoprotein–Mediated Efflux Reduces the In Vivo Efficacy of a Therapeutic Targeting the Gastrointestinal Parasite Cryptosporidium

por Arnold, Samuel L M, Choi, Ryan, Hulverson, Matthew A, Whitman, Grant R, Mccloskey, Molly C, Dorr, Carlie S, Vidadala, Rama S R, Khatod, Mansi, Morada, Mary, Barrett, Lynn K, Maly, Dustin J, Yarlett, Nigel, Van Voorhis, Wesley C
Publicado 2019

Pharmacokinetics and Pharmacodynamics of Clofazimine for Treatment of Cryptosporidiosis

por Zhang, Cindy X., Love, Melissa S., McNamara, Case W., Chi, Victor, Woods, Ashley K., Joseph, Sean, Schaefer, Deborah A., Betzer, Dana P., Riggs, Michael W., Iroh Tam, Pui-Ying, Van Voorhis, Wesley C., Arnold, Samuel L. M.
Publicado 2022

In vitro activity, safety and in vivo efficacy of the novel bumped kinase inhibitor BKI-1748 in non-pregnant and pregnant mice experimentally infected with Neospora caninum tachyzo...

por Imhof, Dennis, Anghel, Nicoleta, Winzer, Pablo, Balmer, Vreni, Ramseier, Jessica, Hänggeli, Kai, Choi, Ryan, Hulverson, Matthew A., Whitman, Grant R., Arnold, Samuel L.M., Ojo, Kayode K., Van Voorhis, Wesley C., Doggett, J. Stone, Ortega-Mora, Luis M., Hemphill, Andrew
Publicado 2021

Endochin-like quinolones (ELQs) and bumped kinase inhibitors (BKIs): Synergistic and additive effects of combined treatments against Neospora caninum infection in vitro and in vivo

por Anghel, Nicoleta, Imhof, Dennis, Winzer, Pablo, Balmer, Vreni, Ramseier, Jessica, Haenggeli, Kai, Choi, Ryan, Hulverson, Matthew A., Whitman, Grant R., Arnold, Samuel L.M., Ojo, Kayode K., Van Voorhis, Wesley C., Doggett, J. Stone, Ortega-Mora, Luis M., Hemphill, Andrew
Publicado 2021

A linked physiologically based pharmacokinetic model for hydroxychloroquine and metabolite desethylhydroxychloroquine in SARS‐CoV‐2(−)/(+) populations

por Steinbronn, Claire, Chhonker, Yashpal S., Stewart, Jenell, Leingang, Hannah, Heller, Kate B., Krows, Meighan L., Paasche‐Orlow, Michael, Bershteyn, Anna, Stankiewicz Karita, Helen C., Agrawal, Vaidehi, Laufer, Miriam, Landovitz, Raphael, Wener, Mark, Murry, Daryl J., Johnston, Christine, Barnabas, Ruanne V., Arnold, Samuel L. M.
Publicado 2023

Necessity of Bumped Kinase Inhibitor Gastrointestinal Exposure in Treating Cryptosporidium Infection

por Arnold, Samuel L. M., Choi, Ryan, Hulverson, Matthew A., Schaefer, Deborah A., Vinayak, Sumiti, Vidadala, Rama S. R., McCloskey, Molly C., Whitman, Grant R., Huang, Wenlin, Barrett, Lynn K., Ojo, Kayode K., Fan, Erkang, Maly, Dustin J., Riggs, Michael W., Striepen, Boris, Van Voorhis, Wesley C.
Publicado 2017

Comparison of Toxicities among Different Bumped Kinase Inhibitor Analogs for Treatment of Cryptosporidiosis

por Hulverson, Matthew A., Choi, Ryan, Schaefer, Deborah A., Betzer, Dana P., McCloskey, Molly C., Whitman, Grant R., Huang, Wenlin, Lee, Sangun, Pranata, Andy, McLeod, Malcolm D., Marsh, Kennan C., Kempf, Dale J., LeRoy, Bruce E., Zafiratos, Mark T., Bielinski, Aimee L., Hackman, Robert C., Ojo, Kayode K., Arnold, Samuel L. M., Barrett, Lynn K., Tzipori, Saul, Riggs, Michael W., Fan, Erkang, Van Voorhis, Wesley C.
Publicado 2023

Clofazimine for Treatment of Cryptosporidiosis in Human Immunodeficiency Virus Infected Adults: An Experimental Medicine, Randomized, Double-blind, Placebo-controlled Phase 2a Tria...

por Iroh Tam, Py, Arnold, S L M, Barrett, L K, Chen, C R, Conrad, T M, Douglas, E, Gordon, M A, Hebert, D, Henrion, M, Hermann, D, Hollingsworth, B, Houpt, E, Jere, K C, Lindblad, R, Love, M S, Makhaza, L, McNamara, C W, Nedi, W, Nyirenda, J, Operario, D J, Phulusa, J, Quinnan, G V, Sawyer, L A, Thole, H, Toto, N, Winter, A, Van Voorhis, W C
Publicado 2020