A Fresh Look at Huntingtin mRNA Processing in Huntington’s Disease

por Romo, Lindsay, Mohn, Emily S., Aronin, Neil
Publicado 2018

CRISPRseek: A Bioconductor Package to Identify Target-Specific Guide RNAs for CRISPR-Cas9 Genome-Editing Systems

por Zhu, Lihua J., Holmes, Benjamin R., Aronin, Neil, Brodsky, Michael H.
Publicado 2014

Frameless multimodal image guidance of localized convection-enhanced delivery of therapeutics in the brain

por van der Bom, Imramsjah M J, Moser, Richard P, Gao, Guanping, Sena-Esteves, Miguel, Aronin, Neil, Gounis, Matthew J
Publicado 2013

Designing siRNA That Distinguish between Genes That Differ by a Single Nucleotide

por Schwarz, Dianne S, Ding, Hongliu, Kennington, Lori, Moore, Jessica T, Schelter, Janell, Burchard, Julja, Linsley, Peter S, Aronin, Neil, Xu, Zuoshang, Zamore, Phillip D
Publicado 2006

A synthetic luciferin improves bioluminescence imaging in live mice

por Evans, Melanie S., Chaurette, Joanna P., Adams, Spencer T., Reddy, Gadarla R., Paley, Miranda A., Aronin, Neil, Prescher, Jennifer A., Miller, Stephen C.
Publicado 2014

Safe and Efficient Silencing with a Pol II, but Not a Pol lII, Promoter Expressing an Artificial miRNA Targeting Human Huntingtin

por Pfister, Edith L., Chase, Kathryn O., Sun, Huaming, Kennington, Lori A., Conroy, Faith, Johnson, Emily, Miller, Rachael, Borel, Florie, Aronin, Neil, Mueller, Christian
Publicado 2017

Huntingtin associates with the actin cytoskeleton and α-actinin isoforms to influence stimulus dependent morphology changes

por Tousley, Adelaide, Iuliano, Maria, Weisman, Elizabeth, Sapp, Ellen, Richardson, Heather, Vodicka, Petr, Alexander, Jonathan, Aronin, Neil, DiFiglia, Marian, Kegel-Gleason, Kimberly B.
Publicado 2019

Large Animal Models of Huntington’s Disease: What We Have Learned and Where We Need to Go Next

por Howland, David, Ellederova, Zdenka, Aronin, Neil, Fernau, Deborah, Gallagher, Jill, Taylor, Amanda, Hennebold, Jon, Weiss, Alison R., Gray-Edwards, Heather, McBride, Jodi
Publicado 2020

Autophagy Activation by Transcription Factor EB (TFEB) in Striatum of HD(Q175/Q7) Mice

por Vodicka, Petr, Chase, Kathryn, Iuliano, Maria, Tousley, Adelaide, Valentine, Dana T., Sapp, Ellen, Kegel-Gleason, Kimberly B., Sena-Esteves, Miguel, Aronin, Neil, DiFiglia, Marian
Publicado 2016

5΄-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo

por Haraszti, Reka A., Roux, Loic, Coles, Andrew H., Turanov, Anton A., Alterman, Julia F., Echeverria, Dimas, Godinho, Bruno M.D.C., Aronin, Neil, Khvorova, Anastasia
Publicado 2017

Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain

por Nikan, Mehran, Osborn, Maire F, Coles, Andrew H, Godinho, Bruno MDC, Hall, Lauren M, Haraszti, Reka A, Hassler, Matthew R, Echeverria, Dimas, Aronin, Neil, Khvorova, Anastasia
Publicado 2016

Mutant huntingtin messenger RNA forms neuronal nuclear clusters in rodent and human brains

por Ly, Socheata, Didiot, Marie-Cécile, Ferguson, Chantal M, Coles, Andrew H, Miller, Rachael, Chase, Kathryn, Echeverria, Dimas, Wang, Feng, Sadri-Vakili, Ghazaleh, Aronin, Neil, Khvorova, Anastasia
Publicado 2022

Allele-Selective Suppression of Mutant Huntingtin in Primary Human Blood Cells

por Miller, James R. C., Pfister, Edith L., Liu, Wanzhao, Andre, Ralph, Träger, Ulrike, Kennington, Lori A., Lo, Kimberly, Dijkstra, Sipke, Macdonald, Douglas, Ostroff, Gary, Aronin, Neil, Tabrizi, Sarah J.
Publicado 2017

High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources

por Haraszti, Reka A., Didiot, Marie-Cecile, Sapp, Ellen, Leszyk, John, Shaffer, Scott A., Rockwell, Hannah E., Gao, Fei, Narain, Niven R., DiFiglia, Marian, Kiebish, Michael A., Aronin, Neil, Khvorova, Anastasia
Publicado 2016

Adeno-Associated Virus Neutralizing Antibodies in Large Animals and Their Impact on Brain Intraparenchymal Gene Transfer

por Wang, Dan, Zhong, Li, Li, Mengxin, Li, Jia, Tran, Karen, Ren, Lingzhi, He, Ran, Xie, Jun, Moser, Richard P., Fraser, Cara, Kuchel, Tim, Sena-Esteves, Miguel, Flotte, Terence R., Aronin, Neil, Gao, Guangping
Publicado 2018

Excitatory transmission onto AgRP neurons is regulated by cJun NH(2)-terminal kinase 3 in response to metabolic stress

por Vernia, Santiago, Morel, Caroline, Madara, Joseph C, Cavanagh-Kyros, Julie, Barrett, Tamera, Chase, Kathryn, Kennedy, Norman J, Jung, Dae Young, Kim, Jason K, Aronin, Neil, Flavell, Richard A, Lowell, Bradford B, Davis, Roger J
Publicado 2016

Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain

por Alterman, Julia F, Hall, Lauren M, Coles, Andrew H, Hassler, Matthew R, Didiot, Marie-Cecile, Chase, Kathryn, Abraham, Jasmin, Sottosanti, Emily, Johnson, Emily, Sapp, Ellen, Osborn, Maire F, Difiglia, Marian, Aronin, Neil, Khvorova, Anastasia
Publicado 2015

Structurally constrained phosphonate internucleotide linkage impacts oligonucleotide-enzyme interaction, and modulates siRNA activity and allele specificity

por Yamada, Ken, Hildebrand, Samuel, Davis, Sarah M, Miller, Rachael, Conroy, Faith, Sapp, Ellen, Caiazzi, Jillian, Alterman, Julia F, Roux, Loic, Echeverria, Dimas, Hassler, Matthew R, Pfister, Edith L, DiFiglia, Marian, Aronin, Neil, Khvorova, Anastasia
Publicado 2021

Rac1 Activity Is Modulated by Huntingtin and Dysregulated in Models of Huntington’s Disease

por Tousley, Adelaide, Iuliano, Maria, Weisman, Elizabeth, Sapp, Ellen, Zhang, Ningzhe, Vodicka, Petr, Alexander, Jonathan, Aviolat, Hubert, Gatune, Leah, Reeves, Patrick, Li, Xueyi, Khvorova, Anastasia, Ellerby, Lisa M., Aronin, Neil, DiFiglia, Marian, Kegel-Gleason, Kimberly B.
Publicado 2019

A RET::GRB2 fusion in pheochromocytoma defies the classic paradigm of RET oncogenic fusions

por Estrada-Zuniga, Cynthia M., Cheng, Zi-Ming, Ethiraj, Purushoth, Guo, Qianjin, Gonzalez-Cantú, Hector, Adderley, Elaina, Lopez, Hector, Landry, Bethany N., Zainal, Abir, Aronin, Neil, Ding, Yanli, Wang, Xiaojing, Aguiar, Ricardo C.T., Dahia, Patricia L.M.
Publicado 2022