Plant Glycosides and Glycosidases: A Treasure-Trove for Therapeutics

por Kytidou, Kassiani, Artola, Marta, Overkleeft, Herman S., Aerts, Johannes M. F. G.
Publicado 2020

Fabry Disease: Molecular Basis, Pathophysiology, Diagnostics and Potential Therapeutic Directions

por Kok, Ken, Zwiers, Kimberley C., Boot, Rolf G., Overkleeft, Hermen S., Aerts, Johannes M. F. G., Artola, Marta
Publicado 2021

Structure of a GH51 α-l-arabinofuranosidase from Meripilus giganteus: conserved substrate recognition from bacteria to fungi

por McGregor, Nicholas G. S., Turkenburg, Johan P., Mørkeberg Krogh, Kristian B. R., Nielsen, Jens Erik, Artola, Marta, Stubbs, Keith A., Overkleeft, Herman S., Davies, Gideon J.
Publicado 2020

Xylose‐Configured Cyclophellitols as Selective Inhibitors for Glucocerebrosidase

por Su, Qin, Schröder, Sybrin P., Lelieveld, Lindsey T., Ferraz, Maria J., Verhoek, Marri, Boot, Rolf G., Overkleeft, Herman S., Aerts, Johannes M. F. G., Artola, Marta, Kuo, Chi‐Lin
Publicado 2021

Fluorescence polarisation activity-based protein profiling for the identification of deoxynojirimycin-type inhibitors selective for lysosomal retaining alpha- and beta-glucosidases

por van der Gracht, Daniël, Rowland, Rhianna J., Roig-Zamboni, Véronique, Ferraz, Maria J., Louwerse, Max, Geurink, Paul P., Aerts, Johannes M. F. G., Sulzenbacher, Gerlind, Davies, Gideon J., Overkleeft, Herman S., Artola, Marta
Publicado 2023

Functionalized Cyclophellitols Are Selective Glucocerebrosidase Inhibitors and Induce a Bona Fide Neuropathic Gaucher Model in Zebrafish

por Artola, Marta, Kuo, Chi-Lin, Lelieveld, Lindsey T., Rowland, Rhianna J., van der Marel, Gijsbert A., Codée, Jeroen D. C., Boot, Rolf G., Davies, Gideon J., Aerts, Johannes M. F. G., Overkleeft, Herman S.
Publicado 2019

In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity‐based protein profiling

por Kuo, Chi‐Lin, Kallemeijn, Wouter W., Lelieveld, Lindsey T., Mirzaian, Mina, Zoutendijk, Iris, Vardi, Ayelet, Futerman, Anthony H., Meijer, Annemarie H., Spaink, Herman P., Overkleeft, Herman S., Aerts, Johannes M.F.G., Artola, Marta
Publicado 2019

Consequences of excessive glucosylsphingosine in glucocerebrosidase-deficient zebrafish.

por Lelieveld, Lindsey T., Gerhardt, Sophie, Maas, Saskia, Zwiers, Kimberley C., de Wit, Claire, Beijk, Ernst H., Ferraz, Maria J., Artola, Marta, Meijer, Annemarie H., Tudorache, Christian, Salvatori, Daniela, Boot, Rolf G., Aerts, Johannes M.F.G.
Publicado 2022

Targeting the FtsZ Allosteric Binding Site with a Novel Fluorescence Polarization Screen, Cytological and Structural Approaches for Antibacterial Discovery

por Huecas, Sonia, Araújo-Bazán, Lidia, Ruiz, Federico M., Ruiz-Ávila, Laura B., Martínez, R. Fernando, Escobar-Peña, Andrea, Artola, Marta, Vázquez-Villa, Henar, Martín-Fontecha, Mar, Fernández-Tornero, Carlos, López-Rodríguez, María L., Andreu, José M.
Publicado 2021

Design, Synthesis and Structural Analysis of Glucocerebrosidase Imaging Agents

por Rowland, Rhianna J., Chen, Yurong, Breen, Imogen, Wu, Liang, Offen, Wendy A., Beenakker, Thomas J., Su, Qin, van den Nieuwendijk, Adrianus M. C. H., Aerts, Johannes M. F. G., Artola, Marta, Overkleeft, Herman S., Davies, Gideon J.
Publicado 2021

Gluco-1H-imidazole: A New Class of Azole-Type β-Glucosidase Inhibitor

por Schröder, Sybrin P., Wu, Liang, Artola, Marta, Hansen, Thomas, Offen, Wendy A., Ferraz, Maria J., Li, Kah-Yee, Aerts, Johannes M. F. G., van der Marel, Gijsbert A., Codée, Jeroen D. C., Davies, Gideon J., Overkleeft, Herman S.
Publicado 2018

Direct Stereoselective Aziridination of Cyclohexenols with 3‐Amino‐2‐(trifluoromethyl)quinazolin‐4(3H)‐one in the Synthesis of Cyclitol Aziridine Glycosidase Inhibitors

por Artola, Marta, Wouters, Shirley, Schröder, Sybrin P., de Boer, Casper, Chen, Yurong, Petracca, Rita, van den Nieuwendijk, Adrianus M. C. H., Aerts, Johannes M. F. G., van der Marel, Gijsbert A., Codée, Jeroen D. C., Overkleeft, Herman S.
Publicado 2019

1,6-epi-Cyclophellitol Cyclosulfamidate Is a Bona Fide Lysosomal α-Glucosidase Stabilizer for the Treatment of Pompe Disease

por Kok, Ken, Kuo, Chi-Lin, Katzy, Rebecca E., Lelieveld, Lindsey T., Wu, Liang, Roig-Zamboni, Véronique, van der Marel, Gijsbert A., Codée, Jeroen D. C., Sulzenbacher, Gerlind, Davies, Gideon J., Overkleeft, Herman S., Aerts, Johannes M. F. G., Artola, Marta
Publicado 2022

The structural assembly switch of cell division protein FtsZ probed with fluorescent allosteric inhibitors

por Artola, Marta, Ruíz-Avila, Laura B., Ramírez-Aportela, Erney, Martínez, R. Fernando, Araujo-Bazán, Lidia, Vázquez-Villa, Henar, Martín-Fontecha, Mar, Oliva, María A., Martín-Galiano, A. Javier, Chacón, Pablo, López-Rodríguez, María L., Andreu, José M., Huecas, Sonia
Publicado 2017

1,6-Cyclophellitol Cyclosulfates: A New Class of Irreversible Glycosidase Inhibitor

por Artola, Marta, Wu, Liang, Ferraz, Maria J., Kuo, Chi-Lin, Raich, Lluís, Breen, Imogen Z., Offen, Wendy A., Codée, Jeroen D. C., van der Marel, Gijsbert A., Rovira, Carme, Aerts, Johannes M. F. G., Davies, Gideon J., Overkleeft, Herman S.
Publicado 2017

Activity-Based Protein Profiling of Retaining α-Amylases in Complex Biological Samples

por Chen, Yurong, Armstrong, Zachary, Artola, Marta, Florea, Bogdan I., Kuo, Chi-Lin, de Boer, Casper, Rasmussen, Mikkel S., Abou Hachem, Maher, van der Marel, Gijsbert A., Codée, Jeroen D. C., Aerts, Johannes M. F. G., Davies, Gideon J., Overkleeft, Herman S.
Publicado 2021

Trans-cyclosulfamidate mannose-configured cyclitol allows isoform-dependent inhibition of GH47 α-d-mannosidases through a bump–hole strategy

por Males, Alexandra, Kok, Ken, Nin-Hill, Alba, de Koster, Nicky, van den Beukel, Sija, Beenakker, Thomas J. M., van der Marel, Gijsbert A., Codée, Jeroen D. C., Aerts, Johannes M. F. G., Overkleeft, Herman S., Rovira, Carme, Davies, Gideon J., Artola, Marta
Publicado 2023

Chemical Proteomics Identifies SLC25A20 as a Functional Target of the Ingenol Class of Actinic Keratosis Drugs

por Parker, Christopher G., Kuttruff, Christian A., Galmozzi, Andrea, Jørgensen, Lars, Yeh, Chien-Hung, Hermanson, Daniel J., Wang, Yujia, Artola, Marta, McKerrall, Steven J., Josyln, Christopher M., Nørremark, Bjarne, Dünstl, Georg, Felding, Jakob, Saez, Enrique, Baran, Phil S., Cravatt, Benjamin F.
Publicado 2017

Rational Design of Mechanism-Based Inhibitors and Activity-Based Probes for the Identification of Retaining α-l-Arabinofuranosidases

por McGregor, Nicholas G. S., Artola, Marta, Nin-Hill, Alba, Linzel, Daniël, Haon, Mireille, Reijngoud, Jos, Ram, Arthur, Rosso, Marie-Noëlle, van der Marel, Gijsbert A., Codée, Jeroen D. C., van Wezel, Gilles P., Berrin, Jean-Guy, Rovira, Carme, Overkleeft, Herman S., Davies, Gideon J.
Publicado 2020

Human glucocerebrosidase mediates formation of xylosyl-cholesterol by β-xylosidase and transxylosidase reactions

por Boer, Daphne E., Mirzaian, Mina, Ferraz, Maria J., Zwiers, Kimberley C., Baks, Merel V., Hazeu, Marc D., Ottenhoff, Roelof, Marques, André R.A., Meijer, Rianne, Roos, Jonathan C.P., Cox, Timothy M., Boot, Rolf G., Pannu, Navraj, Overkleeft, Herman S., Artola, Marta, Aerts, Johannes M.
Publicado 2021