AMPK: Regulating Energy Balance at the Cellular and Whole Body Levels

por Hardie, D. Grahame, Ashford, Michael L. J.
Publicado 2014

BACE1 activity impairs neuronal glucose oxidation: rescue by beta-hydroxybutyrate and lipoic acid

por Findlay, John A., Hamilton, David L., Ashford, Michael L. J.
Publicado 2015

Palmitoylation of the Na/Ca exchanger cytoplasmic loop controls its inactivation and internalization during stress signaling

por Reilly, Louise, Howie, Jacqueline, Wypijewski, Krzysztof, Ashford, Michael L. J., Hilgemann, Donald W., Fuller, William
Publicado 2015

Identification of Caveolar Resident Proteins in Ventricular Myocytes Using a Quantitative Proteomic Approach: Dynamic Changes in Caveolar Composition Following Adrenoceptor Activat...

por Wypijewski, Krzysztof J., Tinti, Michele, Chen, Wenzhang, Lamont, Douglas, Ashford, Michael L. J., Calaghan, Sarah C., Fuller, William
Publicado 2015

Leptin-dependent Phosphorylation of PTEN Mediates Actin Restructuring and Activation of ATP-sensitive K(+) Channels

por Ning, Ke, Miller, Lisa C., Laidlaw, Hilary A., Watterson, Kenneth R., Gallagher, Jennifer, Sutherland, Calum, Ashford, Michael L. J.
Publicado 2009

Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression

por Watterson, Kenneth R., Bestow, Dawn, Gallagher, Jennifer, Hamilton, D. Lee, Ashford, Fiona B., Meakin, Paul J., Ashford, Michael L.J.
Publicado 2012

Altered amyloid precursor protein processing regulates glucose uptake and oxidation in cultured rodent myotubes

por Hamilton, D. Lee, Findlay, John A., Montagut, Gemma, Meakin, Paul J., Bestow, Dawn, Jalicy, Susan M., Ashford, Michael L. J.
Publicado 2014

Oleate induces K(ATP) channel-dependent hyperpolarization in mouse hypothalamic glucose-excited neurons without altering cellular energy charge

por Dadak, Selma, Beall, Craig, Vlachaki Walker, Julia M., Soutar, Marc P.M., McCrimmon, Rory J., Ashford, Michael L.J.
Publicado 2017

Calcium Channel Ca(V)2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons

por Smith, Mark A., Katsouri, Loukia, Virtue, Samuel, Choudhury, Agharul I., Vidal-Puig, Antonio, Ashford, Michael L.J., Withers, Dominic J.
Publicado 2018

Loss of AMP-activated protein kinase α2 subunit in mouse β-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia

por Beall, Craig, Piipari, Kaisa, Al-Qassab, Hind, Smith, Mark A., Parker, Nadeene, Carling, David, Viollet, Benoit, Withers, Dominic J., Ashford, Michael L. J.
Publicado 2010

Mice Lacking beta2-Integrin Function Remain Glucose Tolerant in Spite of Insulin Resistance, Neutrophil Infiltration and Inflammation

por Meakin, Paul J., Morrison, Vicky L., Sneddon, Claire C., Savinko, Terhi, Uotila, Liisa, Jalicy, Susan M., Gabriel, Jennie L., Kang, Li, Ashford, Michael L. J., Fagerholm, Susanna C.
Publicado 2015

Adipocyte integrin-linked kinase plays a key role in the development of diet-induced adipose insulin resistance in male mice

por Bugler-Lamb, Aimée R., Hasib, Annie, Weng, Xiong, Hennayake, Chandani K., Lin, Chenshi, McCrimmon, Rory J., Stimson, Roland H., Ashford, Michael L.J., Wasserman, David H., Kang, Li
Publicado 2021

Susceptibility of Nrf2-Null Mice to Steatohepatitis and Cirrhosis upon Consumption of a High-Fat Diet Is Associated with Oxidative Stress, Perturbation of the Unfolded Protein Resp...

por Meakin, Paul J., Chowdhry, Sudhir, Sharma, Ritu S., Ashford, Fiona B., Walsh, Shaun V., McCrimmon, Rory J., Dinkova-Kostova, Albena T., Dillon, John F., Hayes, John D., Ashford, Michael L. J.
Publicado 2014

The genetic association of the transcription factor NPAT with glycemic response to metformin involves regulation of fuel selection

por Chen, Changwei, Gallagher, Jennifer R., Tarlton, Jamie, van Aalten, Lidy, Bray, Susan E., Ashford, Michael L. J., McCrimmon, Rory J., Pearson, Ewan R., McNeilly, Alison D., Sutherland, Calum
Publicado 2021

The beta secretase BACE1 regulates the expression of insulin receptor in the liver

por Meakin, Paul J., Mezzapesa, Anna, Benabou, Eva, Haas, Mary E., Bonardo, Bernadette, Grino, Michel, Brunel, Jean-Michel, Desbois-Mouthon, Christèle, Biddinger, Sudha B., Govers, Roland, Ashford, Michael L. J., Peiretti, Franck
Publicado 2018

Non-canonical Keap1-independent activation of Nrf2 in astrocytes by mild oxidative stress

por Al-Mubarak, Bashayer R., Bell, Karen F.S., Chowdhry, Sudhir, Meakin, Paul J., Baxter, Paul S., McKay, Sean, Dando, Owen, Ashford, Michael L.J., Gazaryan, Irina, Hayes, John D., Hardingham, Giles E.
Publicado 2021

Chronic hyperglycaemia increases the vulnerability of the hippocampus to oxidative damage induced during post-hypoglycaemic hyperglycaemia in a mouse model of chemically induced ty...

por McNeilly, Alison D., Gallagher, Jennifer R., Evans, Mark L., de Galan, Bastiaan E., Pedersen-Bjergaard, Ulrik, Thorens, Bernard, Dinkova-Kostova, Albena T., Huang, Jeffrey-T., Ashford, Michael L. J., McCrimmon, Rory J.
Publicado 2023

Metformin increases the uptake of glucose into the gut from the circulation in high-fat diet-fed male mice, which is enhanced by a reduction in whole-body Slc2a2 expression

por Morrice, Nicola, Vainio, Susanne, Mikkola, Kirsi, van Aalten, Lidy, Gallagher, Jennifer R., Ashford, Michael L.J., McNeilly, Alison D., McCrimmon, Rory J., Grosfeld, Alexandra, Serradas, Patricia, Koffert, Jukka, Pearson, Ewan R., Nuutila, Pirjo, Sutherland, Calum
Publicado 2023

Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice

por Meakin, Paul J., Harper, Alex J., Hamilton, D. Lee, Gallagher, Jennifer, McNeilly, Alison D., Burgess, Laura A., Vaanholt, Lobke M., Bannon, Kirsten A., Latcham, Judy, Hussain, Ishrut, Speakman, John R., Howlett, David R., Ashford, Michael L.J.
Publicado 2011

Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)

por Sharma, Ritu S., Harrison, David J., Kisielewski, Dorothy, Cassidy, Diane M., McNeilly, Alison D., Gallagher, Jennifer R., Walsh, Shaun V., Honda, Tadashi, McCrimmon, Rory J., Dinkova-Kostova, Albena T., Ashford, Michael L.J., Dillon, John F., Hayes, John D.
Publicado 2017