The aminoguanidine carboxylate BVT.12777 activates ATP-sensitive K(+ )channels in the rat insulinoma cell line, CRI-G1

por Kinsella, Jackie M, Laidlaw, Hilary A, Tang, Teresa, Harvey, Jenni, Sutherland, Calum, Ashford, Michael LJ
Publicado 2004

Central deficiency of IL-6Ra in mice impairs glucose-stimulated insulin secretion

por McNeilly, Alison D., Yianakas, Adonis, Gallagher, Jennifer G., Tarlton, Jamie, Ashford, Michael LJ., McCrimmon, Rory J.
Publicado 2022

Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and K(ATP )channel activation

por Mirshamsi, Shirin, Laidlaw, Hilary A, Ning, Ke, Anderson, Erin, Burgess, Laura A, Gray, Alexander, Sutherland, Calum, Ashford, Michael LJ
Publicado 2004

Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression

por Watterson, Kenneth R., Bestow, Dawn, Gallagher, Jennifer, Hamilton, D. Lee, Ashford, Fiona B., Meakin, Paul J., Ashford, Michael L.J.
Publicado 2012

Oleate induces K(ATP) channel-dependent hyperpolarization in mouse hypothalamic glucose-excited neurons without altering cellular energy charge

por Dadak, Selma, Beall, Craig, Vlachaki Walker, Julia M., Soutar, Marc P.M., McCrimmon, Rory J., Ashford, Michael L.J.
Publicado 2017

Calcium Channel Ca(V)2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons

por Smith, Mark A., Katsouri, Loukia, Virtue, Samuel, Choudhury, Agharul I., Vidal-Puig, Antonio, Ashford, Michael L.J., Withers, Dominic J.
Publicado 2018

Adipocyte integrin-linked kinase plays a key role in the development of diet-induced adipose insulin resistance in male mice

por Bugler-Lamb, Aimée R., Hasib, Annie, Weng, Xiong, Hennayake, Chandani K., Lin, Chenshi, McCrimmon, Rory J., Stimson, Roland H., Ashford, Michael L.J., Wasserman, David H., Kang, Li
Publicado 2021

Non-canonical Keap1-independent activation of Nrf2 in astrocytes by mild oxidative stress

por Al-Mubarak, Bashayer R., Bell, Karen F.S., Chowdhry, Sudhir, Meakin, Paul J., Baxter, Paul S., McKay, Sean, Dando, Owen, Ashford, Michael L.J., Gazaryan, Irina, Hayes, John D., Hardingham, Giles E.
Publicado 2021

Metformin increases the uptake of glucose into the gut from the circulation in high-fat diet-fed male mice, which is enhanced by a reduction in whole-body Slc2a2 expression

por Morrice, Nicola, Vainio, Susanne, Mikkola, Kirsi, van Aalten, Lidy, Gallagher, Jennifer R., Ashford, Michael L.J., McNeilly, Alison D., McCrimmon, Rory J., Grosfeld, Alexandra, Serradas, Patricia, Koffert, Jukka, Pearson, Ewan R., Nuutila, Pirjo, Sutherland, Calum
Publicado 2023

Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice

por Meakin, Paul J., Harper, Alex J., Hamilton, D. Lee, Gallagher, Jennifer, McNeilly, Alison D., Burgess, Laura A., Vaanholt, Lobke M., Bannon, Kirsten A., Latcham, Judy, Hussain, Ishrut, Speakman, John R., Howlett, David R., Ashford, Michael L.J.
Publicado 2011

Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)

por Sharma, Ritu S., Harrison, David J., Kisielewski, Dorothy, Cassidy, Diane M., McNeilly, Alison D., Gallagher, Jennifer R., Walsh, Shaun V., Honda, Tadashi, McCrimmon, Rory J., Dinkova-Kostova, Albena T., Ashford, Michael L.J., Dillon, John F., Hayes, John D.
Publicado 2017

Dominant Role of the p110β Isoform of PI3K over p110α in Energy Homeostasis Regulation by POMC and AgRP Neurons

por Al-Qassab, Hind, Smith, Mark A., Irvine, Elaine E., Guillermet-Guibert, Julie, Claret, Marc, Choudhury, Agharul I., Selman, Colin, Piipari, Kaisa, Clements, Melanie, Lingard, Steven, Chandarana, Keval, Bell, Jimmy D., Barsh, Gregory S., Smith, Andrew J.H., Batterham, Rachel L., Ashford, Michael L.J., Vanhaesebroeck, Bart, Withers, Dominic J.
Publicado 2009

Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction

por Meakin, Paul J., Coull, Bethany M., Tuharska, Zofia, McCaffery, Christopher, Akoumianakis, Ioannis, Antoniades, Charalambos, Brown, Jane, Griffin, Kathryn J., Platt, Fiona, Ozber, Claire H., Yuldasheva, Nadira Y., Makava, Natallia, Skromna, Anna, Prescott, Alan, McNeilly, Alison D., Siddiqui, Moneeza, Palmer, Colin N.A., Khan, Faisel, Ashford, Michael L.J.
Publicado 2020

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

por Bell, Karen F.S., Al-Mubarak, Bashayer, Martel, Marc-André, McKay, Sean, Wheelan, Nicola, Hasel, Philip, Márkus, Nóra M., Baxter, Paul, Deighton, Ruth F., Serio, Andrea, Bilican, Bilada, Chowdhry, Sudhir, Meakin, Paul J., Ashford, Michael L.J., Wyllie, David J.A., Scannevin, Robert H., Chandran, Siddharthan, Hayes, John D., Hardingham, Giles E.
Publicado 2015