Tryptophan scanning mutagenesis as a way to mimic the compound-bound state and probe the selectivity of allosteric inhibitors in cells

por Taylor, Isabelle R., Assimon, Victoria A., Kuo, Szu Yu, Rinaldi, Silvia, Li, Xiaokai, Young, Zapporah T., Morra, Giulia, Green, Keith, Nguyen, Daniel, Shao, Hao, Garneau-Tsodikova, Sylvie, Colombo, Giorgio, Gestwicki, Jason E.
Publicado 2020

Predicting protein targets for drug-like compounds using transcriptomics

por Pabon, Nicolas A., Xia, Yan, Estabrooks, Samuel K., Ye, Zhaofeng, Herbrand, Amanda K., Süß, Evelyn, Biondi, Ricardo M., Assimon, Victoria A., Gestwicki, Jason E., Brodsky, Jeffrey L., Camacho, Carlos J., Bar-Joseph, Ziv
Publicado 2018

Mapping Interactions with the Chaperone Network Reveals Factors that Protect Against Tau Aggregation

por Mok, Sue-Ann, Condello, Carlo, Freilich, Rebecca, Gillies, Anne, Arhar, Taylor, Oroz, Javier, Kadavath, Harindranath, Julien, Olivier, Assimon, Victoria A., Rauch, Jennifer N., Dunyak, Bryan M., Lee, Jungsoon, Tsai, Francis T.F., Wilson, Mark R., Zweckstetter, Markus, Dickey, Chad A., Gestwicki, Jason E.
Publicado 2018