Melatonin improves brain function in a model of chronic Gulf War Illness with modulation of oxidative stress, NLRP3 inflammasomes, and BDNF-ERK-CREB pathway in the hippocampus

por Madhu, Leelavathi N., Kodali, Maheedhar, Attaluri, Sahithi, Shuai, Bing, Melissari, Laila, Rao, Xiaolan, Shetty, Ashok K.
Publicado 2021

Brain-Specific Increase in Leukotriene Signaling Accompanies Chronic Neuroinflammation and Cognitive Impairment in a Model of Gulf War Illness

por Attaluri, Sahithi, Upadhya, Raghavendra, Kodali, Maheedhar, Madhu, Leelavathi N., Upadhya, Dinesh, Shuai, Bing, Shetty, Ashok K.
Publicado 2022

Chronic Oxidative Stress, Mitochondrial Dysfunction, Nrf2 Activation and Inflammation in the Hippocampus Accompany Heightened Systemic Inflammation and Oxidative Stress in an Anima...

por Shetty, Geetha A., Hattiangady, Bharathi, Upadhya, Dinesh, Bates, Adrian, Attaluri, Sahithi, Shuai, Bing, Kodali, Maheedhar, Shetty, Ashok K.
Publicado 2017

Metformin treatment in late middle age improves cognitive function with alleviation of microglial activation and enhancement of autophagy in the hippocampus

por Kodali, Maheedhar, Attaluri, Sahithi, Madhu, Leelavathi N., Shuai, Bing, Upadhya, Raghavendra, Gonzalez, Jenny Jaimes, Rao, Xiaolan, Shetty, Ashok K.
Publicado 2021

A single intranasal dose of human mesenchymal stem cell-derived extracellular vesicles after traumatic brain injury eases neurogenesis decline, synapse loss, and BDNF-ERK-CREB sign...

por Kodali, Maheedhar, Madhu, Leelavathi N., Reger, Roxanne L., Milutinovic, Bojana, Upadhya, Raghavendra, Attaluri, Sahithi, Shuai, Bing, Shankar, Goutham, Shetty, Ashok K.
Publicado 2023

Grafted hPSC-derived GABA-ergic interneurons regulate seizures and specific cognitive function in temporal lobe epilepsy

por Upadhya, Dinesh, Attaluri, Sahithi, Liu, Yan, Hattiangady, Bharathi, Castro, Olagide W., Shuai, Bing, Dong, Yi, Zhang, Su-Chun, Shetty, Ashok K.
Publicado 2022

A Model of Chronic Temporal Lobe Epilepsy Presenting Constantly Rhythmic and Robust Spontaneous Seizures, Co-morbidities and Hippocampal Neuropathology

por Upadhya, Dinesh, Kodali, Maheedhar, Gitai, Daniel, Castro, Olagide W, Zanirati, Gabriele, Upadhya, Raghavendra, Attaluri, Sahithi, Mitra, Eeshika, Shuai, Bing, Hattiangady, Bharathi, Shetty, Ashok K
Publicado 2019

Monosodium luminol reinstates redox homeostasis, improves cognition, mood and neurogenesis, and alleviates neuro- and systemic inflammation in a model of Gulf War Illness

por Shetty, Ashok K., Attaluri, Sahithi, Kodali, Maheedhar, Shuai, Bing, Shetty, Geetha A., Upadhya, Dinesh, Hattiangady, Bharathi, Madhu, Leelavathi N., Upadhya, Raghavendra, Bates, Adrian, Rao, Xiaolan
Publicado 2019

Human induced pluripotent stem cell-derived MGE cell grafting after status epilepticus attenuates chronic epilepsy and comorbidities via synaptic integration

por Upadhya, Dinesh, Hattiangady, Bharathi, Castro, Olagide W., Shuai, Bing, Kodali, Maheedhar, Attaluri, Sahithi, Bates, Adrian, Dong, Yi, Zhang, Su-Chun, Prockop, Darwin J., Shetty, Ashok K.
Publicado 2019

Intranasally Administered Human MSC-Derived Extracellular Vesicles Pervasively Incorporate into Neurons and Microglia in both Intact and Status Epilepticus Injured Forebrain

por Kodali, Maheedhar, Castro, Olagide W., Kim, Dong-Ki, Thomas, Alicia, Shuai, Bing, Attaluri, Sahithi, Upadhya, Raghavendra, Gitai, Daniel, Madhu, Leelavathi N., Prockop, Darwin J., Shetty, Ashok K.
Publicado 2019

Intranasally administered extracellular vesicles from human induced pluripotent stem cell-derived neural stem cells quickly incorporate into neurons and microglia in 5xFAD mice

por Attaluri, Sahithi, Jaimes Gonzalez, Jenny, Kirmani, Maha, Vogel, Andrew D., Upadhya, Raghavendra, Kodali, Maheedhar, Madhu, Leelavathi N., Rao, Shama, Shuai, Bing, Babu, Roshni S., Huard, Charles, Shetty, Ashok K.
Publicado 2023

Extracellular vesicles from human iPSC-derived neural stem cells: miRNA and protein signatures, and anti-inflammatory and neurogenic properties

por Upadhya, Raghavendra, Madhu, Leelavathi N., Attaluri, Sahithi, Gitaí, Daniel Leite Góes, Pinson, Marisa R, Kodali, Maheedhar, Shetty, Geetha, Zanirati, Gabriele, Kumar, Smrithi, Shuai, Bing, Weintraub, Susan T, Shetty, Ashok K.
Publicado 2020

Oral Nano-Curcumin in a Model of Chronic Gulf War Illness Alleviates Brain Dysfunction with Modulation of Oxidative Stress, Mitochondrial Function, Neuroinflammation, Neurogenesis,...

por Attaluri, Sahithi, Arora, Meenakshi, Madhu, Leelavathi N, Kodali, Maheedhar, Shuai, Bing, Melissari, Laila, Upadhya, Raghavendra, Rao, Xiaolan, Bates, Adrian, Mitra, Eeshika, Ghahfarouki, Keyhan R, Ravikumar, M. N. V, Shetty, Ashok K
Publicado 2022