The utility of DNA microarrays for characterizing genotoxicity.

por Newton, Ronald K, Aardema, Marilyn, Aubrecht, Jiri
Publicado 2004

Emerging hepatotoxicity biomarkers and their potential to improve understanding and management of drug-induced liver injury

por Aubrecht, Jiri, Schomaker, Shelli J, Amacher, David E
Publicado 2013

Moving Forward in Human Cancer Risk Assessment

por Paules, Richard S., Aubrecht, Jiri, Corvi, Raffaella, Garthoff, Bernward, Kleinjans, Jos C.
Publicado 2011

Assessment of serum bile acid profiles as biomarkers of liver injury and liver disease in humans

por Luo, Lina, Aubrecht, Jiri, Li, Dingzhou, Warner, Roscoe L., Johnson, Kent J., Kenny, Julia, Colangelo, Jennifer L.
Publicado 2018

The MicroRNA-based Liquid Biopsy Improves Early Assessment of Lethal Acetaminophen Poisoning: A Case Report

por Krauskopf, Julian, Gosink, Mark M., Schomaker, Shelli, Caiment, Florian, Warner, Roscoe, Johnson, Kent, Kleinjans, Jos, Aubrecht, Jiri
Publicado 2020

Acetaminophen Overdose as a Potential Risk Factor for Parkinson's Disease

por Bohler, Sacha, Liu, Xiaosong, Krauskopf, Julian, Caiment, Florian, Aubrecht, Jiri, Nicolaes, Gerry A. F., Kleinjans, Jos C. S., Briedé, Jacco J.
Publicado 2019

Glutamate dehydrogenase as a biomarker for mitotoxicity; insights from furosemide hepatotoxicity in the mouse

por Church, Rachel J., Schomaker, Shelli J., Eaddy, J. Scott, Boucher, Germaine G., Kreeger, John M., Aubrecht, Jiri, Watkins, Paul B.
Publicado 2020

Assessment of the performance of the TGx‐DDI biomarker to detect DNA damage‐inducing agents using quantitative RT‐PCR in TK6 cells

por Cho, Eunnara, Buick, Julie K., Williams, Andrew, Chen, Renxiang, Li, Heng‐Hong, Corton, J. Christopher, Fornace, Albert J., Aubrecht, Jiri, Yauk, Carole L.
Publicado 2018

Assessment of Vedolizumab Disease‐Drug‐Drug Interaction Potential in Patients With Inflammatory Bowel Diseases

por Sun, Wan, Lirio, Richard A., Schneider, Jennifer, Aubrecht, Jiri, Kadali, Harisha, Baratta, Mike, Gulati, Parul, Suri, Ajit, Lin, Tiffany, Vasudevan, Raghavan, Rosario, Maria
Publicado 2020

Application of the TGx‐28.65 transcriptomic biomarker to classify genotoxic and non‐genotoxic chemicals in human TK6 cells in the presence of rat liver S9

por Yauk, Carole L., Buick, Julie K., Williams, Andrew, Swartz, Carol D., Recio, Leslie, Li, Heng‐Hong, Fornace, Albert J., Thomson, Errol M., Aubrecht, Jiri
Publicado 2016

Serum glutamate dehydrogenase activity enables early detection of liver injury in subjects with underlying muscle impairments

por Schomaker, Shelli, Potter, David, Warner, Roscoe, Larkindale, Jane, King, Nicholas, Porter, Amy C., Owens, Jane, Tomlinson, Lindsay, Sauer, John-Michael, Johnson, Kent, Aubrecht, Jiri
Publicado 2020

TGx-DDI, a Transcriptomic Biomarker for Genotoxicity Hazard Assessment of Pharmaceuticals and Environmental Chemicals

por Li, Heng-Hong, Yauk, Carole L., Chen, Renxiang, Hyduke, Daniel R., Williams, Andrew, Frötschl, Roland, Ellinger-Ziegelbauer, Heidrun, Pettit, Syril, Aubrecht, Jiri, Fornace, Albert J.
Publicado 2019

Integration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells

por Buick, Julie K., Moffat, Ivy, Williams, Andrew, Swartz, Carol D., Recio, Leslie, Hyduke, Daniel R., Li, Heng‐Hong, Fornace, Albert J., Aubrecht, Jiri, Yauk, Carole L.
Publicado 2015

A predictive toxicogenomics signature to classify genotoxic versus non-genotoxic chemicals in human TK6 cells

por Williams, Andrew, Buick, Julie K., Moffat, Ivy, Swartz, Carol D., Recio, Leslie, Hyduke, Daniel R., Li, Heng-Hong, Fornace, Albert J., Aubrecht, Jiri, Yauk, Carole L.
Publicado 2015

Development and validation of a high-throughput transcriptomic biomarker to address 21st century genetic toxicology needs

por Li, Heng-Hong, Chen, Renxiang, Hyduke, Daniel R., Williams, Andrew, Frötschl, Roland, Ellinger-Ziegelbauer, Heidrun, O’Lone, Raegan, Yauk, Carole L., Aubrecht, Jiri, Fornace, Albert J.
Publicado 2017

Phase I study of PF‐04895162, a Kv7 channel opener, reveals unexpected hepatotoxicity in healthy subjects, but not rats or monkeys: clinical evidence of disrupted bile acid homeost...

por Aleo, Michael D., Aubrecht, Jiri, D. Bonin, Paul, Burt, Deborah A., Colangelo, Jennifer, Luo, Lina, Schomaker, Shelli, Swiss, Rachel, Kirby, Simon, C. Rigdon, Greg, Dua, Pinky
Publicado 2019

Serum microRNA signatures as "liquid biopsies" for interrogating hepatotoxic mechanisms and liver pathogenesis in human

por Krauskopf, Julian, de Kok, Theo M., Schomaker, Shelli J., Gosink, Mark, Burt, Deborah A., Chandler, Patricia, Warner, Roscoe L., Johnson, Kent J., Caiment, Florian, Kleinjans, Jos C., Aubrecht, Jiri
Publicado 2017

Integrated Genotoxicity Testing of three anti-infective drugs using the TGx-DDI transcriptomic biomarker and high-throughput CometChip(®) assay in TK6 cells

por Buick, Julie K., Rowan-Carroll, Andrea, Gagné, Rémi, Williams, Andrew, Chen, Renxiang, Li, Heng-Hong, Fornace, Albert J., Chao, Christy, Engelward, Bevin P., Frötschl, Roland, Ellinger-Ziegelbauer, Heidrun, Pettit, Syril D., Aubrecht, Jiri, Yauk, Carole L.
Publicado 2022

Genetic Variants Associated with Non-Alcoholic Fatty Liver Disease Do Not Associate with Measures of Sub-Clinical Atherosclerosis: Results from the IMPROVE Study

por Castaldo, Luigi, Laguzzi, Federica, Strawbridge, Rona J., Baldassarre, Damiano, Veglia, Fabrizio, Vigo, Lorenzo, Tremoli, Elena, de Faire, Ulf, Eriksson, Per, Smit, Andries J., Aubrecht, Jiri, Leander, Karin, Pirro, Matteo, Giral, Philippe, Ritieni, Alberto, Di Minno, Giovanni, Mälarstig, Anders, Gigante, Bruna
Publicado 2020