The Impact of the C-Terminal Domain on the Interaction of Human DNA Topoisomerase II α and β with DNA

por Gilroy, Kathryn L., Austin, Caroline A.
Publicado 2011

Mechanism of Generation of Therapy Related Leukemia in Response to Anti-Topoisomerase II Agents

por Cowell, Ian G., Austin, Caroline A.
Publicado 2012

Do transcription factories and TOP2B provide a recipe for chromosome translocations in therapy-related leukemia?

por Cowell, Ian G., Austin, Caroline A.
Publicado 2012

DNA fragility at the KMT2A/MLL locus: insights from old and new technologies

por Cowell, Ian G., Austin, Caroline A.
Publicado 2023

To Break or Not to Break: The Role of TOP2B in Transcription

por Cowell, Ian G., Casement, John W., Austin, Caroline A.
Publicado 2023

Myeloperoxidase Enhances Etoposide and Mitoxantrone-Mediated DNA Damage: A Target for Myeloprotection in Cancer Chemotherapy

por Atwal, Mandeep, Lishman, Emma L., Austin, Caroline A., Cowell, Ian G.
Publicado 2017

The Impact of the Human DNA Topoisomerase II C-Terminal Domain on Activity

por Meczes, Emma L., Gilroy, Kathryn L., West, Katherine L., Austin, Caroline A.
Publicado 2008

mAMSA resistant human topoisomerase IIβ mutation G465D has reduced ATP hydrolysis activity

por Gilroy, Kathryn L., Leontiou, Chrysoula, Padget, Kay, Lakey, Jeremy H., Austin, Caroline A.
Publicado 2006

Small Molecule Inhibitors Confirm Ubiquitin-Dependent Removal of TOP2-DNA Covalent Complexes

por Swan, Rebecca L., Poh, Luke L.K., Cowell, Ian G., Austin, Caroline A.
Publicado 2020

Role of Topoisomerase IIβ in DNA Damage Response following IR and Etoposide

por Sunter, Nicola J., Cowell, Ian G., Willmore, Elaine, Watters, Gary P., Austin, Caroline A.
Publicado 2010

Proteasomal inhibition potentiates drugs targeting DNA topoisomerase II

por Lee, Ka C., Bramley, Rebecca L., Cowell, Ian G., Jackson, Graham H., Austin, Caroline A.
Publicado 2016

Effect of TDP2 on the Level of TOP2-DNA Complexes and SUMOylated TOP2-DNA Complexes

por Lee, Ka Cheong, Swan, Rebecca L., Sondka, Zbyslaw, Padget, Kay, Cowell, Ian G., Austin, Caroline A.
Publicado 2018

The Deubiquitinating Enzyme Inhibitor PR-619 is a Potent DNA Topoisomerase II Poison

por Cowell, Ian G., Ling, Elise M., Swan, Rebecca L., Brooks, Matilda L.W., Austin, Caroline A.
Publicado 2019

A complex suite of loci and elements in eukaryotic type II topoisomerases determine selective sensitivity to distinct poisoning agents

por Blower, Tim R, Bandak, Afif, Lee, Amy S Y, Austin, Caroline A, Nitiss, John L, Berger, James M
Publicado 2019

γH2AX Foci Form Preferentially in Euchromatin after Ionising-Radiation

por Cowell, Ian G., Sunter, Nicola J., Singh, Prim B., Austin, Caroline A., Durkacz, Barbara W., Tilby, Michael J.
Publicado 2007

A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193

por Ling, Elise M., Baslé, Arnaud, Cowell, Ian G., van den Berg, Bert, Blower, Tim R., Austin, Caroline A.
Publicado 2022

Distinct expression patterns for type II topoisomerases IIA and IIB in the early foetal human telencephalon

por Harkin, Lauren F., Gerrelli, Dianne, Gold Diaz, Diana C., Santos, Chloe, Alzu'bi, Ayman, Austin, Caroline A., Clowry, Gavin J.
Publicado 2015

TOP2B: The First Thirty Years

por Austin, Caroline A., Lee, Ka C., Swan, Rebecca L., Khazeem, Mushtaq M., Manville, Catriona M., Cridland, Peter, Treumann, Achim, Porter, Andrew, Morris, Nick J., Cowell, Ian G.
Publicado 2018

TOP2B Is Required to Maintain the Adrenergic Neural Phenotype and for ATRA-Induced Differentiation of SH-SY5Y Neuroblastoma Cells

por Khazeem, Mushtaq M., Casement, John W., Schlossmacher, George, Kenneth, Niall S., Sumbung, Nielda K., Chan, Janice Yuen Tung, McGow, Jade F., Cowell, Ian G., Austin, Caroline A.
Publicado 2022

Genome-wide ChIP-seq analysis of human TOP2B occupancy in MCF7 breast cancer epithelial cells

por Manville, Catriona M., Smith, Kayleigh, Sondka, Zbyslaw, Rance, Holly, Cockell, Simon, Cowell, Ian G., Lee, Ka Cheong, Morris, Nicholas J., Padget, Kay, Jackson, Graham H., Austin, Caroline A.
Publicado 2015