Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity

por Stockton, Rebecca A., Shenkar, Robert, Awad, Issam A., Ginsberg, Mark H.
Publicado 2010

Cerebral Cavernous Malformation Proteins in Barrier Maintenance and Regulation

por Wei, Shu, Li, Ye, Polster, Sean P., Weber, Christopher R., Awad, Issam A., Shen, Le
Publicado 2020

Abortive intussusceptive angiogenesis causes multi-cavernous vascular malformations

por Li, Wenqing, Tran, Virginia, Shaked, Iftach, Xue, Belinda, Moore, Thomas, Lightle, Rhonda, Kleinfeld, David, Awad, Issam A, Ginsberg, Mark H
Publicado 2021

Single-nucleus DNA sequencing reveals hidden somatic loss-of-heterozygosity in Cerebral Cavernous Malformations

por Ressler, Andrew K., Snellings, Daniel A., Girard, Romuald, Gallione, Carol J., Lightle, Rhonda, Allen, Andrew S., Awad, Issam A., Marchuk, Douglas A.
Publicado 2023

COVID-19 in a Hemorrhagic Neurovascular Disease, Cerebral Cavernous Malformation

por Shkoukani, Abdallah, Srinath, Abhinav, Stadnik, Agnieszka, Girard, Romuald, Shenkar, Robert, Sheline, Adrienne, Dahlem, Kristen, Lee, Cornelia, Flemming, Kelly, Awad, Issam A.
Publicado 2021

Case Report: Management of Traumatic Carotid-Cavernous Fistulas in the Acute Setting of Penetrating Brain Injury

por Loggini, Andrea, Kass-Hout, Tareq, Awad, Issam A., El Ammar, Faten, Kramer, Christopher L., Goldenberg, Fernando D., Lazaridis, Christos, Mansour, Ali
Publicado 2022

CSF and serum inflammatory response and association with outcomes in spontaneous intracerebral hemorrhage with intraventricular extension: an analysis of the CLEAR-III Trial

por Gusdon, Aaron M., Thompson, Carol B., Quirk, Kendel, Mayasi, Yunis M., Avadhani, Radhika, Awad, Issam A., Hanley, Daniel F., Ziai, Wendy C.
Publicado 2021

Inflammatory Mechanisms in a Neurovascular Disease: Cerebral Cavernous Malformation

por Li, Ying, Srinath, Abhinav, Alcazar-Felix, Roberto J., Hage, Stephanie, Bindal, Akash, Lightle, Rhonda, Shenkar, Robert, Shi, Changbin, Girard, Romuald, Awad, Issam A.
Publicado 2023

Developmental venous anomalies are a genetic primer for cerebral cavernous malformations

por Snellings, Daniel A., Girard, Romuald, Lightle, Rhonda, Srinath, Abhinav, Romanos, Sharbel, Li, Ying, Chen, Chang, Ren, Aileen A., Kahn, Mark L., Awad, Issam A., Marchuk, Douglas A.
Publicado 2022

Propranolol as therapy for cerebral cavernous malformations: a cautionary note

por Shenkar, Robert, Moore, Thomas, Benavides, Christian, Lightle, Rhonda, Detter, Matthew R., Hobson, Nicholas, Girard, Romuald, DeBiasse, Dorothy, Patrucco, Mary, Gallione, Carol, Zabramski, Joseph M., Marchuk, Douglas A., Awad, Issam A.
Publicado 2022

Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations

por Lopez-Ramirez, Miguel Alejandro, Fonseca, Gregory, Zeineddine, Hussein A., Girard, Romuald, Moore, Thomas, Pham, Angela, Cao, Ying, Shenkar, Robert, de Kreuk, Bart-Jan, Lagarrigue, Frederic, Lawler, Jack, Glass, Christopher K., Awad, Issam A., Ginsberg, Mark H.
Publicado 2017

A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis

por Chapman, Eric M., Lant, Benjamin, Ohashi, Yota, Yu, Bin, Schertzberg, Michael, Go, Christopher, Dogra, Deepika, Koskimäki, Janne, Girard, Romuald, Li, Yan, Fraser, Andrew G., Awad, Issam A., Abdelilah-Seyfried, Salim, Gingras, Anne-Claude, Derry, W. Brent
Publicado 2019

Quantitative Susceptibility Mapping and Vessel Wall Imaging as Screening Tools to Detect Microbleed in Sentinel Headache

por Ishii, Daizo, Nakagawa, Daichi, Zanaty, Mario, Roa, Jorge A., Al Kasab, Sami, Shaban, Amir, Hudson, Joseph S., Osorno-Cruz, Carlos, Byer, Stefano, Allan, Lauren, Torner, James C., Awad, Issam A., Carroll, Timothy J., Samaniego, Edgar A., Hasan, David M.
Publicado 2020

Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signaling

por Zhou, Zinan, Tang, Alan T., Wong, Weng-Yew, Bamezai, Sharika, Goddard, Lauren M., Shenkar, Robert, Zhou, Su, Yang, Jisheng, Wright, Alexander C., Foley, Matthew, Arthur, J. Simon C., Whitehead, Kevin J., Awad, Issam A., Li, Dean Y., Zheng, Xiangjian, Kahn, Mark L.
Publicado 2016

Leukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieu

por Goods, Brittany A., Askenase, Michael H., Markarian, Erica, Beatty, Hannah E., Drake, Riley S., Fleming, Ira, DeLong, Jonathan H., Philip, Naomi H., Matouk, Charles C., Awad, Issam A., Zuccarello, Mario, Hanley, Daniel F., Love, J. Christopher, Shalek, Alex K., Sansing, Lauren H.
Publicado 2021

EXCEPTIONAL AGGRESSIVENESS OF CEREBRAL CAVERNOUS MALFORMATION DISEASE ASSOCIATED WITH PDCD10 MUTATIONS

por Shenkar, Robert, Shi, Changbin, Rebeiz, Tania, Stockton, Rebecca A., McDonald, David A., Mikati, Abdul Ghani, Zhang, Lingjiao, Austin, Cecilia, Akers, Amy L., Gallione, Carol J., Rorrer, Autumn, Gunel, Murat, Min, Wang, De Souza, Jorge Marcondes, Lee, Connie, Marchuk, Douglas A., Awad, Issam A.
Publicado 2014

Phenotypic Characterization of Murine Models of Cerebral Cavernous Malformations

por Zeineddine, Hussein A., Girard, Romuald, Saadat, Laleh, Shen, Le, Lightle, Rhonda, Moore, Thomas, Cao, Ying, Hobson, Nick, Shenkar, Robert, Avner, Kenneth, Chaudager, Kiranj, Koskimäki, Janne, Polster, Sean P., Fam, Maged D., Shi, Changbin, Lopez-Ramirez, Miguel Alejandro, Tang, Alan T., Gallione, Carol, Kahn, Mark L., Ginsberg, Mark, Marchuk, Douglas A., Awad, Issam A.
Publicado 2018

Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma

por Polster, Sean P., Sharma, Anukriti, Tanes, Ceylan, Tang, Alan T., Mericko, Patricia, Cao, Ying, Carrión-Penagos, Julián, Girard, Romuald, Koskimäki, Janne, Zhang, Dongdong, Stadnik, Agnieszka, Romanos, Sharbel G., Lyne, Seán B., Shenkar, Robert, Yan, Kimberly, Lee, Cornelia, Akers, Amy, Morrison, Leslie, Robinson, Myranda, Zafar, Atif, Bittinger, Kyle, Kim, Helen, Gilbert, Jack A., Kahn, Mark L., Shen, Le, Awad, Issam A.
Publicado 2020

Endothelial TLR4 and the microbiome drive cerebral cavernous malformations

por Tang, Alan T., Choi, Jaesung P., Kotzin, Jonathan J., Yang, Yiqing, Hong, Courtney C., Hobson, Nicholas, Girard, Romuald, Zeineddine, Hussein A., Lightle, Rhonda, Moore, Thomas, Cao, Ying, Shenkar, Robert, Chen, Mei, Mericko, Patricia, Yang, Jisheng, Li, Li, Tanes, Ceylan, Kobuley, Dmytro, Võsa, Urmo, Whitehead, Kevin J., Li, Dean Y., Franke, Lude, Hart, Blaine, Schwaninger, Markus, Henao-Mejia, Jorge, Morrison, Leslie, Kim, Helen, Awad, Issam A., Zheng, Xiangjian, Kahn, Mark L.
Publicado 2017

Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations

por Koskimäki, Janne, Zhang, Dongdong, Li, Yan, Saadat, Laleh, Moore, Thomas, Lightle, Rhonda, Polster, Sean P., Carrión-Penagos, Julián, Lyne, Seán B., Zeineddine, Hussein A., Shi, Changbin, Shenkar, Robert, Romanos, Sharbel, Avner, Kenneth, Srinath, Abhinav, Shen, Le, Detter, Matthew R., Snellings, Daniel, Cao, Ying, Lopez-Ramirez, Miguel A., Fonseca, Gregory, Tang, Alan T., Faber, Pieter, Andrade, Jorge, Ginsberg, Mark, Kahn, Mark L., Marchuk, Douglas A., Girard, Romuald, Awad, Issam A.
Publicado 2019