IDO1 Inhibition Reduces Immune Cell Exclusion Through Inducing Cell Migration While PD-1 Blockage Increases IL-6 and -8 Secretion From T Cells in Head and Neck Cancer

por Sieviläinen, Meri, Saavalainen, Jordan, Adnan-Awad, Shady, Salo, Tuula, Al-Samadi, Ahmed
Publicado 2022

Crosstalk between tongue carcinoma cells, extracellular vesicles, and immune cells in in vitro and in vivo models

por Al-Samadi, Ahmed, Awad, Shady Adnan, Tuomainen, Katja, Zhao, Yue, Salem, Abdelhakim, Parikka, Mataleena, Salo, Tuula
Publicado 2017

A novel class of somatic mutations in blood detected preferentially in CD8 + cells

por Valori, Miko, Jansson, Lilja, Kiviharju, Anna, Ellonen, Pekka, Rajala, Hanna, Awad, Shady Adnan, Mustjoki, Satu, Tienari, Pentti J.
Publicado 2017

Targeting Apoptosis Pathways With BCL2 and MDM2 Inhibitors in Adult B-cell Acute Lymphoblastic Leukemia

por Hohtari, Helena, Kankainen, Matti, Adnan-Awad, Shady, Yadav, Bhagwan, Potdar, Swapnil, Ianevski, Aleksandr, Dufva, Olli, Heckman, Caroline, Sexl, Veronika, Kytölä, Soili, Mustjoki, Satu, Porkka, Kimmo
Publicado 2022

Epigenetic modifier gene mutations in chronic myeloid leukemia (CML) at diagnosis are associated with risk of relapse upon treatment discontinuation

por Adnan Awad, Shady, Brück, Oscar, Shanmuganathan, Naranie, Jarvinen, Timo, Lähteenmäki, Hanna, Klievink, Jay, Ibrahim, Hazem, Kytölä, Soili, Koskenvesa, Perttu, Hughes, Timothy P., Branford, Susan, Kankainen, Matti, Mustjoki, Satu
Publicado 2022

P1228: GENOME-WIDE CRISPR-CAS9 SCREENING IDENTIFIES THERAPEUTIC TARGETS FOR MATURE T-CELL MALIGNANCIES

por Timonen, Sanna, Rebecca Gasparini, Vanessa, Piekkari, Ella, Dufva, Olli, Awad, Shady, Akimov, Yevhen, von Jan, Jana, Braun, Till, Ianevski, Aleksandr, Kankainen, Matti, Klievink, Jay, Herling, Marco, Aittokallio, Tero, Mustjoki, Satu
Publicado 2023

Characterization of p190-Bcr-Abl chronic myeloid leukemia reveals specific signaling pathways and therapeutic targets

por Adnan-Awad, Shady, Kim, Daehong, Hohtari, Helena, Javarappa, Komal Kumar, Brandstoetter, Tania, Mayer, Isabella, Potdar, Swapnil, Heckman, Caroline A., Kytölä, Soili, Porkka, Kimmo, Doma, Eszter, Sexl, Veronika, Kankainen, Matti, Mustjoki, Satu
Publicado 2020

RUNX1 mutations in blast-phase chronic myeloid leukemia associate with distinct phenotypes, transcriptional profiles, and drug responses

por Adnan Awad, Shady, Dufva, Olli, Ianevski, Aleksandr, Ghimire, Bishwa, Koski, Jan, Maliniemi, Pilvi, Thomson, Daniel, Schreiber, Andreas, Heckman, Caroline A., Koskenvesa, Perttu, Korhonen, Matti, Porkka, Kimmo, Branford, Susan, Aittokallio, Tero, Kankainen, Matti, Mustjoki, Satu
Publicado 2020

miR-22 and miR-205 Drive Tumor Aggressiveness of Mucoepidermoid Carcinomas of Salivary Glands

por Naakka, Erika, Barros-Filho, Mateus Camargo, Adnan-Awad, Shady, Al-Samadi, Ahmed, Marchi, Fábio Albuquerque, Kuasne, Hellen, Korelin, Katja, Suleymanova, Ilida, Brown, Amy Louise, Scapulatempo-Neto, Cristovam, Lourenço, Silvia Vanessa, Castilho, Rogério Moraes, Kowalski, Luiz Paulo, Mäkitie, Antti, Araújo, Vera Cavalcanti, Leivo, Ilmo, Rogatto, Silvia Regina, Salo, Tuula, Passador-Santos, Fabricio
Publicado 2022

Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target

por Dufva, Olli, Kankainen, Matti, Kelkka, Tiina, Sekiguchi, Nodoka, Awad, Shady Adnan, Eldfors, Samuli, Yadav, Bhagwan, Kuusanmäki, Heikki, Malani, Disha, Andersson, Emma I, Pietarinen, Paavo, Saikko, Leena, Kovanen, Panu E., Ojala, Teija, Lee, Dean A., Loughran, Thomas P., Nakazawa, Hideyuki, Suzumiya, Junji, Suzuki, Ritsuro, Ko, Young Hyeh, Kim, Won Seog, Chuang, Shih-Sung, Aittokallio, Tero, Chan, Wing C., Ohshima, Koichi, Ishida, Fumihiro, Mustjoki, Satu
Publicado 2018

Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia

por Kuusanmäki, Heikki, Dufva, Olli, Vähä-Koskela, Markus, Leppä, Aino-Maija, Huuhtanen, Jani, Vänttinen, Ida, Nygren, Petra, Klievink, Jay, Bouhlal, Jonas, Pölönen, Petri, Zhang, Qi, Adnan-Awad, Shady, Mancebo-Pérez, Cristina, Saad, Joseph, Miettinen, Juho, Javarappa, Komal K., Aakko, Sofia, Ruokoranta, Tanja, Eldfors, Samuli, Heinäniemi, Merja, Theilgaard-Mönch, Kim, Wartiovaara-Kautto, Ulla, Keränen, Mikko, Porkka, Kimmo, Konopleva, Marina, Wennerberg, Krister, Kontro, Mika, Heckman, Caroline A., Mustjoki, Satu
Publicado 2023