Editorial: The next generation of tools and technologies for studying human neurons in a dish

por Durcan, Thomas M., Axtman, Alison D.
Publicado 2023

Exploration of Aberrant E3 Ligases Implicated in Alzheimer’s Disease and Development of Chemical Tools to Modulate Their Function

por Potjewyd, Frances M., Axtman, Alison D.
Publicado 2021

Evaluation of a Selective Chemical Probe Validates That CK2 Mediates Neuroinflammation in a Human Induced Pluripotent Stem Cell-Derived Mircroglial Model

por Mishra, Swati, Kinoshita, Chizuru, Axtman, Alison D., Young, Jessica E.
Publicado 2022

PKIS deep dive yields a chemical starting point for dark kinases and a cell active BRSK2 inhibitor

por Tamir, Tigist Y., Drewry, David H., Wells, Carrow, Major, M. Ben, Axtman, Alison D.
Publicado 2020

Function through bio-inspired, synthesis-informed design: step-economical syntheses of designed kinase inhibitors

por Wender, Paul A., Axtman, Alison D., Golden, Jennifer E., Kee, Jung-Min, Sirois, Lauren E., Quiroz, Ryan V., Stevens, Matthew C.
Publicado 2014

Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration

por Drewry, David H., Annor-Gyamfi, Joel K., Wells, Carrow I., Pickett, Julie E., Dederer, Verena, Preuss, Franziska, Mathea, Sebastian, Axtman, Alison D.
Publicado 2021

REDOR NMR Reveals Multiple Conformers for a Protein Kinase C Ligand in a Membrane Environment

por Yang, Hao, Staveness, Daryl, Ryckbosch, Steven M., Axtman, Alison D., Loy, Brian A., Barnes, Alexander B., Pande, Vijay S., Schaefer, Jacob, Wender, Paul A., Cegelski, Lynette
Publicado 2018

Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis

por Bashore, Frances M., Marquez, Ariana B., Chaikuad, Apirat, Howell, Stefanie, Dunn, Andrea S., Beltran, Alvaro A., Smith, Jeffery L., Drewry, David H., Beltran, Adriana S., Axtman, Alison D.
Publicado 2023

Optimization of 3-Cyano-7-cyclopropylamino-pyrazolo[1,5-a]pyrimidines Toward the Development of an In Vivo Chemical Probe for CSNK2A

por Yang, Xuan, Ong, Han Wee, Dickmander, Rebekah J., Smith, Jeffery L., Brown, Jason W., Tao, William, Chang, Edcon, Moorman, Nathaniel J., Axtman, Alison D., Willson, Timothy M.
Publicado 2023

Optimization of 3-Cyano-7-cyclopropylamino-pyrazolo[1,5-a]pyrimidines toward the Development of an In Vivo Chemical Probe for CSNK2A

por Yang, Xuan, Ong, Han Wee, Dickmander, Rebekah J., Smith, Jeffery L., Brown, Jason W., Tao, William, Chang, Edcon, Moorman, Nathaniel J., Axtman, Alison D., Willson, Timothy M.
Publicado 2023

Protein proximity networks and functional evaluation of the casein kinase 1 gamma family reveal unique roles for CK1γ3 in WNT signaling

por Agajanian, Megan J., Potjewyd, Frances M., Bowman, Brittany M., Solomon, Smaranda, LaPak, Kyle M., Bhatt, Dhaval P., Smith, Jeffery L., Goldfarb, Dennis, Axtman, Alison D., Major, Michael B.
Publicado 2022

Fused Tetrahydroquinolines Are Interfering with Your Assay

por Bashore, Frances M., Annor-Gyamfi, Joel, Du, Yuhong, Katis, Vittorio, Nwogbo, Felix, Flax, Raymond G., Frye, Stephen V., Pearce, Kenneth H., Fu, Haian, Willson, Timothy M., Drewry, David H., Axtman, Alison D.
Publicado 2023

Open drug discovery in Alzheimer's disease

por Axtman, Alison D., Brennan, Paul E., Frappier‐Brinton, Tristan, Betarbet, Ranjita, Carter, Gregory W., Fu, Haian, Gileadi, Opher, Greenwood, Anna K., Leal, Karina, Longo, Frank M., Mangravite, Lara M., Edwards, Aled M., Levey, Allan I.
Publicado 2023

Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2

por Davis-Gilbert, Zachary W., Krämer, Andreas, Dunford, James E., Howell, Stefanie, Senbabaoglu, Filiz, Wells, Carrow I., Bashore, Frances M., Havener, Tammy M., Smith, Jeffery L., Hossain, Mohammad A., Oppermann, Udo, Drewry, David H., Axtman, Alison D.
Publicado 2023

Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses

por Drewry, David H., Potjewyd, Frances M., Bayati, Armin, Smith, Jeffery L., Dickmander, Rebekah J., Howell, Stefanie, Taft-Benz, Sharon, Min, Sophia M., Hossain, Mohammad Anwar, Heise, Mark, McPherson, Peter S., Moorman, Nathaniel J., Axtman, Alison D.
Publicado 2022

Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective

por Ong, Han Wee, Liang, Yi, Richardson, William, Lowry, Emily R., Wells, Carrow I., Chen, Xiangrong, Silvestre, Margaux, Dempster, Kelvin, Silvaroli, Josie A., Smith, Jeffery L., Wichterle, Hynek, Pabla, Navjot S., Ultanir, Sila K., Bullock, Alex N., Drewry, David H., Axtman, Alison D.
Publicado 2023

A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective

por Ong, Han Wee, Liang, Yi, Richardson, William, Lowry, Emily R., Wells, Carrow I., Chen, Xiangrong, Silvestre, Margaux, Dempster, Kelvin, Silvaroli, Josie A., Smith, Jeffery L., Wichterle, Hynek, Pabla, Navjot S., Ultanir, Sila K., Bullock, Alex N., Drewry, David H., Axtman, Alison D.
Publicado 2023

Development of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic strategy for Alzheimer’s disease

por Du, Yuhong, Bradshaw, William J., Leisner, Tina M., Annor-Gyamfi, Joel K., Qian, Kun, Bashore, Frances M., Sikdar, Arunima, Nwogbo, Felix O., Ivanov, Andrey A., Frye, Stephen V., Gileadi, Opher, Brennan, Paul E., Levey, Allan I., Axtman, Alison D., Pearce, Kenneth H., Fu, Haian, Katis, Vittorio L.
Publicado 2023

Discovery of FERM domain protein–protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer’s disease

por Du, Yuhong, Bradshaw, William J., Leisner, Tina M., Annor-Gyamfi, Joel K., Qian, Kun, Bashore, Frances M., Sikdar, Arunima, Nwogbo, Felix O., Ivanov, Andrey A., Frye, Stephen V., Gileadi, Opher, Brennan, Paul E., Levey, Allan I., Axtman, Alison D., Pearce, Kenneth H., Fu, Haian, Katis, Vittorio L.
Publicado 2023

Host kinase CSNK2 is a target for inhibition of pathogenic β-coronaviruses including SARS-CoV-2

por Yang, Xuan, Dickmander, Rebekah J., Bayati, Armin, Taft-Benz, Sharon A., Smith, Jeffery L., Wells, Carrow I., Madden, Emily A., Brown, Jason W., Lenarcic, Erik M., Yount, Boyd L., Chang, Edcon, Axtman, Alison D., Baric, Ralph S., Heise, Mark T., McPherson, Peter S., Moorman, Nathaniel J., Willson, Timothy M.
Publicado 2022