TDP-43 dysfunction results in R-loop accumulation and DNA replication defects

por Wood, Matthew, Quinet, Annabel, Lin, Yea-Lih, Davis, Albert A., Pasero, Philippe, Ayala, Yuna M., Vindigni, Alessandro
Publicado 2020

TDP-43 Oligomerization and Phase Separation Properties Are Necessary for Autoregulation

por Koehler, Lydia C., Grese, Zachary R., Bastos, Alliny C. S., Mamede, Lohany D., Heyduk, Tomasz, Ayala, Yuna M.
Publicado 2022

TDP-43 α-helical structure tunes liquid–liquid phase separation and function

por Conicella, Alexander E., Dignon, Gregory L., Zerze, Gül H., Schmidt, Hermann Broder, D’Ordine, Alexandra M., Kim, Young C., Rohatgi, Rajat, Ayala, Yuna M., Mittal, Jeetain, Fawzi, Nicolas L.
Publicado 2020

A single N‐terminal phosphomimic disrupts TDP‐43 polymerization, phase separation, and RNA splicing

por Wang, Ailin, Conicella, Alexander E, Schmidt, Hermann Broder, Martin, Erik W, Rhoads, Shannon N, Reeb, Ashley N, Nourse, Amanda, Ramirez Montero, Daniel, Ryan, Veronica H, Rohatgi, Rajat, Shewmaker, Frank, Naik, Mandar T, Mittag, Tanja, Ayala, Yuna M, Fawzi, Nicolas L
Publicado 2018

VCP suppresses proteopathic seeding in neurons

por Zhu, Jiang, Pittman, Sara, Dhavale, Dhruva, French, Rachel, Patterson, Jessica N., Kaleelurrrahuman, Mohamed Salman, Sun, Yuanzi, Vaquer-Alicea, Jaime, Maggiore, Gianna, Clemen, Christoph S., Buscher, William J., Bieschke, Jan, Kotzbauer, Paul, Ayala, Yuna, Diamond, Marc I., Davis, Albert A., Weihl, Conrad
Publicado 2022