Quantitative system pharmacology as a legitimate approach to examine extrapolation strategies used to support pediatric drug development

por Azer, Karim, Barrett, Jeffrey S.
Publicado 2022

Role of Disease Progression Models in Drug Development

por Barrett, Jeffrey S., Nicholas, Tim, Azer, Karim, Corrigan, Brian W.
Publicado 2022

Linear-In-Flux-Expressions Methodology: Toward a Robust Mathematical Framework for Quantitative Systems Pharmacology Simulators

por McQuade, Sean T, Abrams, Ruth E, Barrett, Jeffrey S, Piccoli, Benedetto, Azer, Karim
Publicado 2017

Reconstruction of the Cytokine Signaling in Lysosomal Storage Diseases by Literature Mining and Network Analysis

por Parolo, Silvia, Tomasoni, Danilo, Bora, Pranami, Ramponi, Alan, Kaddi, Chanchala, Azer, Karim, Domenici, Enrico, Neves-Zaph, Susana, Lombardo, Rosario
Publicado 2021

ABNORMAL SKELETAL METABOLISM BUT NOT CARDIAC DYSFUNCTION AS A CAUSE FOR FATIGUE POST COVID-19

por Cassar, Mark Philip, Finnigan, Lucy, Ashkir, Zakariye, Koziel, Margaret, Zhao, Jeff, Azer, Karim, Valkovic, Ladislav, Neubauer, Stefan, Raman, Betty
Publicado 2023

QSPcc reduces bottlenecks in computational model simulations

por Tomasoni, Danilo, Paris, Alessio, Giampiccolo, Stefano, Reali, Federico, Simoni, Giulia, Marchetti, Luca, Kaddi, Chanchala, Neves-Zaph, Susana, Priami, Corrado, Azer, Karim, Lombardo, Rosario
Publicado 2021

Efficacy and tolerability of an endogenous metabolic modulator (AXA1125) in fatigue-predominant long COVID: a single-centre, double-blind, randomised controlled phase 2a pilot stud...

por Finnigan, Lucy E.M., Cassar, Mark Philip, Koziel, Margaret James, Pradines, Joel, Lamlum, Hanan, Azer, Karim, Kirby, Dan, Montgomery, Hugh, Neubauer, Stefan, Valkovič, Ladislav, Raman, Betty
Publicado 2023

History and Future Perspectives on the Discipline of Quantitative Systems Pharmacology Modeling and Its Applications

por Azer, Karim, Kaddi, Chanchala D., Barrett, Jeffrey S., Bai, Jane P. F., McQuade, Sean T., Merrill, Nathaniel J., Piccoli, Benedetto, Neves-Zaph, Susana, Marchetti, Luca, Lombardo, Rosario, Parolo, Silvia, Immanuel, Selva Rupa Christinal, Baliga, Nitin S.
Publicado 2021

Quantitative Systems Pharmacology Modeling of Acid Sphingomyelinase Deficiency and the Enzyme Replacement Therapy Olipudase Alfa Is an Innovative Tool for Linking Pathophysiology a...

por Kaddi, Chanchala D., Niesner, Bradley, Baek, Rena, Jasper, Paul, Pappas, John, Tolsma, John, Li, Jing, van Rijn, Zachary, Tao, Mengdi, Ortemann‐Renon, Catherine, Easton, Rachael, Tan, Sharon, Puga, Ana Cristina, Schuchman, Edward H., Barrett, Jeffrey S., Azer, Karim
Publicado 2018

A Quantitative Systems Pharmacology Model of Gaucher Disease Type 1 Provides Mechanistic Insight Into the Response to Substrate Reduction Therapy With Eliglustat

por Abrams, Ruth, Kaddi, Chanchala D., Tao, Mengdi, Leiser, Randolph J., Simoni, Giulia, Reali, Federico, Tolsma, John, Jasper, Paul, van Rijn, Zachary, Li, Jing, Niesner, Bradley, Barrett, Jeffrey S., Marchetti, Luca, Peterschmitt, M. Judith, Azer, Karim, Neves‐Zaph, Susana
Publicado 2020

A Quantitative Systems Pharmacology Platform to Investigate the Impact of Alirocumab and Cholesterol-Lowering Therapies on Lipid Profiles and Plaque Characteristics

por Ming, Jeffrey E, Abrams, Ruth E, Bartlett, Derek W, Tao, Mengdi, Nguyen, Tu, Surks, Howard, Kudrycki, Katherine, Kadambi, Ananth, Friedrich, Christina M, Djebli, Nassim, Goebel, Britta, Koszycki, Alex, Varshnaya, Meera, Elassal, Joseph, Banerjee, Poulabi, Sasiela, William J, Reed, Michael J, Barrett, Jeffrey S, Azer, Karim
Publicado 2017

Discovery and Clinical Evaluation of MK‐8150, A Novel Nitric Oxide Donor With a Unique Mechanism of Nitric Oxide Release

por Knox, Clayton D., de Kam, Pieter‐Jan, Azer, Karim, Wong, Peggy, Ederveen, Antwan G., Shevell, Diane, Morabito, Christopher, Meehan, Alan G., Liu, Wen, Reynders, Tom, Denef, Jean Francois, Mitselos, Anna, Jonathan, Daniel, Gutstein, David E., Mitra, Kaushik, Sun, Shu Yu, Lo, Michael Man‐Chu, Cully, Doris, Ali, Amjad
Publicado 2016