Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6

por Baker, Nicola, Alsford, Sam, Horn, David
Publicado 2011

Genetic dissection of drug resistance in trypanosomes

por ALSFORD, SAM, KELLY, JOHN M., BAKER, NICOLA, HORN, DAVID
Publicado 2013

Aquaglyceroporin-null trypanosomes display glycerol transport defects and respiratory-inhibitor sensitivity

por Jeacock, Laura, Baker, Nicola, Wiedemar, Natalie, Mäser, Pascal, Horn, David
Publicado 2017

Pentamidine Is Not a Permeant but a Nanomolar Inhibitor of the Trypanosoma brucei Aquaglyceroporin-2

por Song, Jie, Baker, Nicola, Rothert, Monja, Henke, Björn, Jeacock, Laura, Horn, David, Beitz, Eric
Publicado 2016

Chimerization at the AQP2–AQP3 locus is the genetic basis of melarsoprol–pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates

por Graf, Fabrice E., Baker, Nicola, Munday, Jane C., de Koning, Harry P., Horn, David, Mäser, Pascal
Publicado 2015

Point-of-care echocardiography in simulation-based education and assessment

por Amini, Richard, Stolz, Lori A, Javedani, Parisa P, Gaskin, Kevin, Baker, Nicola, Ng, Vivienne, Adhikari, Srikar
Publicado 2016

Sonography and hypotension: a change to critical problem solving in undergraduate medical education

por Amini, Richard, Stolz, Lori A, Hernandez, Nicholas C, Gaskin, Kevin, Baker, Nicola, Sanders, Arthur Barry, Adhikari, Srikar
Publicado 2016

Insights into antitrypanosomal drug mode-of-action from cytology-based profiling

por Thomas, James A., Baker, Nicola, Hutchinson, Sebastian, Dominicus, Caia, Trenaman, Anna, Glover, Lucy, Alsford, Sam, Horn, David
Publicado 2018

Chemogenomic Profiling of Antileishmanial Efficacy and Resistance in the Related Kinetoplastid Parasite Trypanosoma brucei

por Collett, Clare F., Kitson, Carl, Baker, Nicola, Steele-Stallard, Heather B., Santrot, Marie-Victoire, Hutchinson, Sebastian, Horn, David, Alsford, Sam
Publicado 2019

High-throughput decoding of anti-trypanosomal drug efficacy and resistance

por Alsford, Sam, Eckert, Sabine, Baker, Nicola, Glover, Lucy, Sanchez-Flores, Alejandro, Leung, Ka Fai, Turner, Daniel J., Field, Mark C., Berriman, Matthew, Horn, David
Publicado 2012

Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense

por Graf, Fabrice E., Ludin, Philipp, Arquint, Christian, Schmidt, Remo S., Schaub, Nadia, Kunz Renggli, Christina, Munday, Jane C., Krezdorn, Jessica, Baker, Nicola, Horn, David, Balmer, Oliver, Caccone, Adalgisa, de Koning, Harry P., Mäser, Pascal
Publicado 2016

Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs

por Munday, Jane C., Eze, Anthonius A., Baker, Nicola, Glover, Lucy, Clucas, Caroline, Aguinaga Andrés, David, Natto, Manal J., Teka, Ibrahim A., McDonald, Jennifer, Lee, Rebecca S., Graf, Fabrice E., Ludin, Philipp, Burchmore, Richard J. S., Turner, C. Michael R., Tait, Andy, MacLeod, Annette, Mäser, Pascal, Barrett, Michael P., Horn, David, De Koning, Harry P.
Publicado 2014

Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis

por Smith, Alasdair, Wall, Richard J., Patterson, Stephen, Rowan, Tim, Rico Vidal, Eva, Stojanovski, Laste, Huggett, Margaret, Hampton, Shahienaz E., Thomas, Michael G., Corpas Lopez, Victoriano, Gillingwater, Kirsten, Duke, Jeff, Napier, Grant, Peter, Rose, Vitouley, Hervé S., Harrison, Justin R., Milne, Rachel, Jeacock, Laura, Baker, Nicola, Davis, Susan H., Simeons, Frederick, Riley, Jennifer, Horn, David, Brun, Reto, Zuccotto, Fabio, Witty, Michael J, Wyllie, Susan, Read, Kevin D., Gilbert, Ian H.
Publicado 2022