Balancing Nonsense Mutation Readthrough and Toxicity of Designer Aminoglycosides for Treatment of Genetic Diseases

por Guchhait, Sandip, Khononov, Alina, Pieńko, Tomasz, Belakhov, Valery, Baasov, Timor
Publicado 2023

Gene-based treatment options for Usher type 1C by translational read-through of a nonsense mutation

por Wolfrum, U, Goldmann, T, Overlack, N, Möller, F, Belakov, V, Baasov, T, Nagel-Wolfrum, K
Publicado 2012

Readthrough of nonsense mutations in Rett syndrome: evaluation of novel aminoglycosides and generation of a new mouse model

por Brendel, Cornelia, Belakhov, Valery, Werner, Hauke, Wegener, Eike, Gärtner, Jutta, Nudelman, Igor, Baasov, Timor, Huppke, Peter
Publicado 2010

Erratum to: Readthrough of nonsense mutations in Rett syndrome: evaluation of novel aminoglycosides and generation of a new mouse model

por Brendel, Cornelia, Belakhov, Valery, Werner, Hauke, Wegener, Eike, Gärtner, Jutta, Nudelman, Igor, Baasov, Timor, Huppke, Peter
Publicado 2013

Dynamic Intramolecular Cap for Preserving Metallodrug Integrity—A Case of Catalytic Fluoroquinolones

por Goldmeier, Moshe N., Khononov, Alina, Belakhov, Valery, Pieńko, Tomasz, Orbach, Noam, Gilad Barzilay, Yuval, Baasov, Timor
Publicado 2022

A comparative evaluation of NB30, NB54 and PTC124 in translational read-through efficacy for treatment of an USH1C nonsense mutation

por Goldmann, Tobias, Overlack, Nora, Möller, Fabian, Belakhov, Valery, van Wyk, Michiel, Baasov, Timor, Wolfrum, Uwe, Nagel-Wolfrum, Kerstin
Publicado 2012

Ex Vivo Treatment with a Novel Synthetic Aminoglycoside NB54 in Primary Fibroblasts from Rett Syndrome Patients Suppresses MECP2 Nonsense Mutations

por Vecsler, Manuela, Ben Zeev, Bruria, Nudelman, Igor, Anikster, Yair, Simon, Amos J., Amariglio, Ninette, Rechavi, Gideon, Baasov, Timor, Gak, Eva
Publicado 2011

Structural basis for selective targeting of leishmanial ribosomes: aminoglycoside derivatives as promising therapeutics

por Shalev, Moran, Rozenberg, Haim, Smolkin, Boris, Nasereddin, Abedelmajeed, Kopelyanskiy, Dmitry, Belakhov, Valery, Schrepfer, Thomas, Schacht, Jochen, Jaffe, Charles L., Adir, Noam, Baasov, Timor
Publicado 2015

Attenuation of Nonsense-Mediated mRNA Decay Enhances In Vivo Nonsense Suppression

por Keeling, Kim M., Wang, Dan, Dai, Yanying, Murugesan, Srinivasan, Chenna, Balachandra, Clark, Jeremy, Belakhov, Valery, Kandasamy, Jeyakumar, Velu, Sadanandan E., Baasov, Timor, Bedwell, David M.
Publicado 2013