Viability of primary osteoblasts after treatment with tenofovir alafenamide: Lack of cytotoxicity at clinically relevant drug concentrations

por Callebaut, Christian, Liu, Yang, Babusis, Darius, Ray, Adrian, Miller, Michael, Kitrinos, Kathryn
Publicado 2017

Two-dose emtricitabine/tenofovir alafenamide plus bictegravir prophylaxis protects macaques against SHIV infection

por Bekerman, Elena, Cox, Stephanie, Babusis, Darius, Campigotto, Federico, Das, Moupali, Barouch, Dan H, Cihlar, Tomas, Callebaut, Christian
Publicado 2020

GS-9219/VDC-1101 - a prodrug of the acyclic nucleotide PMEG has antitumor activity inspontaneous canine multiple myeloma

por Thamm, Douglas H, Vail, David M, Kurzman, Ilene D, Babusis, Darius, Ray, Adrian S, Sousa-Powers, Noel, Tumas, Daniel B
Publicado 2014

Pharmacokinetic, Pharmacodynamic, and Drug-Interaction Profile of Remdesivir, a SARS-CoV-2 Replication Inhibitor

por Humeniuk, Rita, Mathias, Anita, Kirby, Brian J., Lutz, Justin D., Cao, Huyen, Osinusi, Anu, Babusis, Darius, Porter, Danielle, Wei, Xuelian, Ling, John, Reddy, Y. Sunila, German, Polina
Publicado 2021

Pomalidomide Shows Significant Therapeutic Activity against CNS Lymphoma with a Major Impact on the Tumor Microenvironment in Murine Models

por Li, Zhimin, Qiu, Yushi, Personett, David, Huang, Peng, Edenfield, Brandy, Katz, Jason, Babusis, Darius, Tang, Yang, Shirely, Michael A., Moghaddam, Mehran F., Copland, John A., Tun, Han W.
Publicado 2013

Nucleotide Prodrug Containing a Nonproteinogenic Amino Acid To Improve Oral Delivery of a Hepatitis C Virus Treatment

por Feng, Joy Y., Wang, Ting, Park, Yeojin, Babusis, Darius, Birkus, Gabriel, Xu, Yili, Voitenleitner, Christian, Fenaux, Martijn, Yang, Huiling, Eng, Stacey, Tirunagari, Neeraj, Kirschberg, Thorsten, Cho, Aesop, Ray, Adrian S.
Publicado 2018

Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus

por Feng, Joy Y., Xu, Yili, Barauskas, Ona, Perry, Jason K., Ahmadyar, Shekeba, Stepan, George, Yu, Helen, Babusis, Darius, Park, Yeojin, McCutcheon, Krista, Perron, Michel, Schultz, Brian E., Sakowicz, Roman, Ray, Adrian S.
Publicado 2016

Off-Target In Vitro Profiling Demonstrates that Remdesivir Is a Highly Selective Antiviral Agent

por Xu, Yili, Barauskas, Ona, Kim, Cynthia, Babusis, Darius, Murakami, Eisuke, Kornyeyev, Dmytro, Lee, Gary, Stepan, George, Perron, Michel, Bannister, Roy, Schultz, Brian E., Sakowicz, Roman, Porter, Danielle, Cihlar, Tomas, Feng, Joy Y.
Publicado 2021

The Nucleoside/Nucleotide Analogs Tenofovir and Emtricitabine Are Inactive against SARS-CoV-2

por Feng, Joy Y., Du Pont, Venice, Babusis, Darius, Gordon, Calvin J., Tchesnokov, Egor P., Perry, Jason K., Duong, Vincent, Vijjapurapu, Arya, Zhao, Xiaofeng, Chan, Julie, Cohen, Cal, Juneja, Kavita, Cihlar, Tomas, Götte, Matthias, Bilello, John P.
Publicado 2022

Intravenous delivery of GS-441524 is efficacious in the African green monkey model of SARS-CoV-2 infection

por Pitts, Jared, Babusis, Darius, Vermillion, Meghan S., Subramanian, Raju, Barrett, Kim, Lye, Diane, Ma, Bin, Zhao, Xiaofeng, Riola, Nicholas, Xie, Xuping, Kajon, Adriana, Lu, Xianghan, Bannister, Roy, Shi, Pei-Yong, Toteva, Maria, Porter, Danielle P., Smith, Bill J., Cihlar, Tomas, Mackman, Richard, Bilello, John P.
Publicado 2022

Sensitivity of Mitochondrial Transcription and Resistance of RNA Polymerase II Dependent Nuclear Transcription to Antiviral Ribonucleosides

por Arnold, Jamie J., Sharma, Suresh D., Feng, Joy Y., Ray, Adrian S., Smidansky, Eric D., Kireeva, Maria L., Cho, Aesop, Perry, Jason, Vela, Jennifer E., Park, Yeojin, Xu, Yili, Tian, Yang, Babusis, Darius, Barauskus, Ona, Peterson, Blake R., Gnatt, Averell, Kashlev, Mikhail, Zhong, Weidong, Cameron, Craig E.
Publicado 2012

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

por Sheahan, Timothy P., Sims, Amy C., Leist, Sarah R., Schäfer, Alexandra, Won, John, Brown, Ariane J., Montgomery, Stephanie A., Hogg, Alison, Babusis, Darius, Clarke, Michael O., Spahn, Jamie E., Bauer, Laura, Sellers, Scott, Porter, Danielle, Feng, Joy Y., Cihlar, Tomas, Jordan, Robert, Denison, Mark R., Baric, Ralph S.
Publicado 2020

Subcutaneous remdesivir administration prevents interstitial pneumonia in rhesus macaques inoculated with SARS-CoV-2

por Williamson, Brandi N., Pérez-Pérez, Lizzette, Schwarz, Benjamin, Feldmann, Friederike, Holbrook, Myndi G., Singh, Manmeet, Lye, Diane S., Babusis, Darius, Subramanian, Raju, Haddock, Elaine, Okumura, Atsushi, Hanley, Patrick W., Lovaglio, Jamie, Bosio, Catharine M., Porter, Danielle P., Cihlar, Tomas, Mackman, Richard L., Saturday, Greg, de Wit, Emmie
Publicado 2022

Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets

por Cox, Robert M., Wolf, Josef D., Lieber, Carolin M., Sourimant, Julien, Lin, Michelle J., Babusis, Darius, DuPont, Venice, Chan, Julie, Barrett, Kim T., Lye, Diane, Kalla, Rao, Chun, Kwon, Mackman, Richard L., Ye, Chengjin, Cihlar, Tomas, Martinez-Sobrido, Luis, Greninger, Alexander L., Bilello, John P., Plemper, Richard K.
Publicado 2021

Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells

por Li, Ruidong, Liclican, Albert, Xu, Yili, Pitts, Jared, Niu, Congrong, Zhang, Jingyu, Kim, Cynthia, Zhao, Xiaofeng, Soohoo, Daniel, Babusis, Darius, Yue, Qin, Ma, Bin, Murray, Bernard P., Subramanian, Raju, Xie, Xuping, Zou, Jing, Bilello, John P., Li, Li, Schultz, Brian E., Sakowicz, Roman, Smith, Bill J., Shi, Pei-Yong, Murakami, Eisuke, Feng, Joy Y.
Publicado 2021

539. Efficacy in Multiple SARS-CoV-2 Animal Models Supports Phase 3 Dose Selection for Obeldesivir

por Pitts, Jared, Babusis, Darius, Humeniuk, Rita, Martinez, David, Cox, Robert M, Schäfer, Alexandra, Riola, Nicholas C, Feng, Joy, Du Pont, Venice, Anoshchenko, Olena, Vermillion, Meghan, Abdelghany, Mazin, Hyland, Robert H, Girish, Sandhya, Sheahan, Timothy P, Plemper, Richard K, Baric, Ralph S, Cihlar, Tomas, Llewellyn, Joe, Winter, Helen, Bannister, Roy, Subramanian, Raju, Mackman, Richard L, Bilello, John P
Publicado 2023

Broad-spectrum Investigational Agent GS-5734 for the Treatment of Ebola, MERS Coronavirus and Other Pathogenic Viral Infections with High Outbreak Potential

por Jordan, Robert, Hogg, Alison, Warren, Travis, De Wit, Emmie, Sheahan, Timothy, Lo, Michael, Soloveva, Veronica, Weidner, Jessica, Gomba, Laura, Feldmann, Friederike, Cronin, Jacqueline, Sims, Amy, Cockrell, Adam, Feng, Joy, Trantcheva, Iva, Babusis, Darius, Porter-Poulin, Danielle, Bannister, Roy, Mackman, Richard, Siegel, Dustin, Ray, Adrian, Denison, Mark, Spiropoulou, Christina, Nichol, Stuart, Cihlar, Tomas, Baric, Ralph, Feldmann, Heinrich, Bavari, Sina
Publicado 2017

Therapeutic efficacy of an oral nucleoside analog of remdesivir against SARS-CoV-2 pathogenesis in mice.

por Schäfer, Alexandra, Martinez, David R., Won, John J., Moreira, Fernando R., Brown, Ariane J., Gully, Kendra L., Kalla, Rao, Chun, Kwon, Du Pont, Venice, Babusis, Darius, Tang, Jennifer, Murakami, Eisuke, Subramanian, Raju, Barrett, Kimberly T, Bleier, Blake J., Bannister, Roy, Feng, Joy Y., Bilello, John P., Cihlar, Tomas, Mackman, Richard L., Montgomery, Stephanie A., Baric, Ralph S., Sheahan, Timothy P.
Publicado 2021

Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection

por Vermillion, Meghan S., Murakami, Eisuke, Ma, Bin, Pitts, Jared, Tomkinson, Adrian, Rautiola, Davin, Babusis, Darius, Irshad, Hammad, Siegel, Dustin, Kim, Cynthia, Zhao, Xiaofeng, Niu, Congrong, Yang, Jesse, Gigliotti, Andrew, Kadrichu, Nani, Bilello, John P., Ellis, Scott, Bannister, Roy, Subramanian, Raju, Smith, Bill, Mackman, Richard L., Lee, William A., Kuehl, Philip J., Hartke, Jim, Cihlar, Tomas, Porter, Danielle P.
Publicado 2021

Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in mice

por Schäfer, Alexandra, Martinez, David R., Won, John J., Meganck, Rita M., Moreira, Fernando R., Brown, Ariane J., Gully, Kendra L., Zweigart, Mark R., Conrad, William S., May, Samantha R., Dong, Stephanie, Kalla, Rao, Chun, Kwon, Du Pont, Venice, Babusis, Darius, Tang, Jennifer, Murakami, Eisuke, Subramanian, Raju, Barrett, Kimberly T., Bleier, Blake J., Bannister, Roy, Feng, Joy Y., Bilello, John P., Cihlar, Tomas, Mackman, Richard L., Montgomery, Stephanie A., Baric, Ralph S., Sheahan, Timothy P.
Publicado 2022