The NLRP1 and CARD8 inflammasomes

por Taabazuing, Cornelius Y., Griswold, Andrew R., Bachovchin, Daniel A.
Publicado 2020

The NLRP1 Inflammasome Induces Pyroptosis in Human Corneal Epithelial Cells

por Griswold, Andrew R., Huang, Hsin-Che, Bachovchin, Daniel A.
Publicado 2022

Substrate-Free High-Throughput Screening Identifies Selective Inhibitors for Uncharacterized Enzymes

por Bachovchin, Daniel A., Brown, Steven J., Rosen, Hugh, Cravatt, Benjamin F.
Publicado 2009

Click-generated triazole ureas as ultrapotent, in vivo-active serine hydrolase inhibitors

por Adibekian, Alexander, Martin, Brent R., Wang, Chu, Hsu, Ku-Lung, Bachovchin, Daniel A., Niessen, Sherry, Hoover, Heather, Cravatt, Benjamin F.
Publicado 2011

DPP8/9 inhibitors are universal activators of functional NLRP1 alleles

por Gai, Kuo, Okondo, Marian C., Rao, Sahana D., Chui, Ashley J., Ball, Daniel P., Johnson, Darren C., Bachovchin, Daniel A.
Publicado 2019

DPP9’s Enzymatic Activity and Not Its Binding to CARD8 Inhibits Inflammasome Activation

por Griswold, Andrew R., Ball, Daniel P., Bhattacharjee, Abir, Chui, Ashley J., Rao, Sahana D., Taabazuing, Cornelius Y., Bachovchin, Daniel A.
Publicado 2019

DPP8/9 inhibitors activate the CARD8 inflammasome in resting lymphocytes

por Johnson, Darren C., Okondo, Marian C., Orth, Elizabeth L., Rao, Sahana D., Huang, Hsin-Che, Ball, Daniel P., Bachovchin, Daniel A.
Publicado 2020

Quantitative reactivity profiling predicts functional cysteines in proteomes

por Weerapana, Eranthie, Wang, Chu, Simon, Gabriel M., Richter, Florian, Khare, Sagar, Dillon, Myles B.D., Bachovchin, Daniel A., Mowen, Kerri, Baker, David, Cravatt, Benjamin F.
Publicado 2010

Activation of the CARD8 Inflammasome Requires a Disordered Region

por Chui, Ashley J., Griswold, Andrew R., Taabazuing, Cornelius Y., Orth, Elizabeth L., Gai, Kuo, Rao, Sahana D., Ball, Daniel P., Hsiao, Jeffrey C., Bachovchin, Daniel A.
Publicado 2020

The NLRP1 and CARD8 inflammasomes detect reductive stress

por Wang, Qinghui, Hsiao, Jeffrey C., Yardeny, Noah, Huang, Hsin-Che, O’Mara, Claire M., Orth-He, Elizabeth L., Ball, Daniel P., Zhang, Ze, Bachovchin, Daniel A.
Publicado 2023

Caspase-1 interdomain linker cleavage is required for pyroptosis

por Ball, Daniel P, Taabazuing, Cornelius Y, Griswold, Andrew R, Orth, Elizabeth L, Rao, Sahana D, Kotliar, Ilana B, Vostal, Lauren E, Johnson, Darren C, Bachovchin, Daniel A
Publicado 2020

Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes

por Robert Hollingsworth, L., David, Liron, Li, Yang, Griswold, Andrew R., Ruan, Jianbin, Sharif, Humayun, Fontana, Pietro, Orth-He, Elizabeth L., Fu, Tian-Min, Bachovchin, Daniel A., Wu, Hao
Publicado 2021

Chemoproteomic profiling of host and pathogen enzymes active in cholera

por Hatzios, Stavroula K., Abel, Sören, Martell, Julianne, Hubbard, Troy, Sasabe, Jumpei, Munera, Diana, Clark, Lars, Bachovchin, Daniel A., Qadri, Firdausi, Ryan, Edward T., Davis, Brigid M., Weerapana, Eranthie, Waldor, Matthew K.
Publicado 2016

DPP8/9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia

por Johnson, Darren C., Taabazuing, Cornelius Y., Okondo, Marian C., Chui, Ashley J., Rao, Sahana D., Brown, Fiona C., Reed, Casie, Peguero, Elizabeth, de Stanchina, Elisa, Kentsis, Alex, Bachovchin, Daniel A.
Publicado 2018

A small molecule inhibitor prevents gut bacterial genotoxin production

por Volpe, Matthew R., Velilla, José A., Daniel-Ivad, Martin, Yao, Jenny J., Stornetta, Alessia, Villalta, Peter W., Huang, Hsin-Che, Bachovchin, Daniel A., Balbo, Silvia, Gaudet, Rachelle, Balskus, Emily P.
Publicado 2022

A ubiquitin-independent proteasome pathway controls activation of the CARD8 inflammasome

por Hsiao, Jeffrey C., Neugroschl, Atara R., Chui, Ashley J., Taabazuing, Cornelius Y., Griswold, Andrew R., Wang, Qinghui, Huang, Hsin-Che, Orth-He, Elizabeth L., Ball, Daniel P., Hiotis, Giorgos, Bachovchin, Daniel A.
Publicado 2022

General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases

por Tichá, Anežka, Stanchev, Stancho, Vinothkumar, Kutti R., Mikles, David C., Pachl, Petr, Began, Jakub, Škerle, Jan, Švehlová, Kateřina, Nguyen, Minh T.N., Verhelst, Steven H.L., Johnson, Darren C., Bachovchin, Daniel A., Lepšík, Martin, Majer, Pavel, Strisovsky, Kvido
Publicado 2017

A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity

por Bachovchin, Daniel A., Koblan, Luke W., Wu, Wengen, Liu, Yuxin, Li, Youhua, Zhao, Peng, Woznica, Iwona, Shu, Ying, Lai, Jack H., Poplawski, Sarah E., Kiritsy, Christopher P., Healey, Sarah E., DiMare, Matthew, Sanford, David G., Munford, Robert S., Bachovchin, William W., Golub, Todd R.
Publicado 2014

Target-Based Screen Against a Periplasmic Serine Protease That Regulates Intrabacterial pH Homeostasis in Mycobacterium tuberculosis

por Zhao, Nan, Darby, Crystal M., Small, Jennifer, Bachovchin, Daniel A., Jiang, Xiuju, Burns-Huang, Kristin E., Botella, Helene, Ehrt, Sabine, Boger, Dale L., Anderson, Erin D., Cravatt, Benjamin F., Speers, Anna E., Fernandez-Vega, Virneliz, Hodder, Peter S., Eberhart, Christina, Rosen, Hugh, Spicer, Timothy P., Nathan, Carl F.
Publicado 2014