The SNM1A DNA repair nuclease

por Baddock, Hannah T., Yosaatmadja, Yuliana, Newman, Joseph A., Schofield, Christopher J., Gileadi, Opher, McHugh, Peter J.
Publicado 2020

EXD2 promotes homologous recombination by facilitating DNA-end resection

por Broderick, Ronan, Nieminuszczy, Jadwiga, Baddock, Hannah T., Deshpande, Rajashree, Gileadi, Opher, Paull, Tanya T., McHugh, Peter J, Niedzwiedz, Wojciech
Publicado 2016

A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family

por Baddock, Hannah T, Newman, Joseph A, Yosaatmadja, Yuliana, Bielinski, Marcin, Schofield, Christopher J, Gileadi, Opher, McHugh, Peter J
Publicado 2021

A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A

por Doherty, William, Dürr, Eva-Maria, Baddock, Hannah T., Lee, Sook Y., McHugh, Peter J., Brown, Tom, Senge, Mathias O., Scanlan, Eoin M., McGouran, Joanna F.
Publicado 2019

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition

por Yosaatmadja, Yuliana, Baddock, Hannah T, Newman, Joseph A, Bielinski, Marcin, Gavard, Angeline E, Mukhopadhyay, Shubhashish M M, Dannerfjord, Adam A, Schofield, Christopher J, McHugh, Peter J, Gileadi, Opher
Publicado 2021

Characterization of the SARS-CoV-2 ExoN (nsp14(ExoN)–nsp10) complex: implications for its role in viral genome stability and inhibitor identification

por Baddock, Hannah T, Brolih, Sanja, Yosaatmadja, Yuliana, Ratnaweera, Malitha, Bielinski, Marcin, Swift, Lonnie P, Cruz-Migoni, Abimael, Fan, Haitian, Keown, Jeremy R, Walker, Alexander P, Morris, Garrett M, Grimes, Jonathan M, Fodor, Ervin, Schofield, Christopher J, Gileadi, Opher, McHugh, Peter J
Publicado 2022

Discovery of reactive peptide inhibitors of human papillomavirus oncoprotein E6

por Ye, Xiyun, Zhang, Peiyuan, Tao, Jason, Wang, John C. K., Mafi, Amirhossein, Grob, Nathalie M., Quartararo, Anthony J., Baddock, Hannah T., Chan, Leanne J. G., McAllister, Fiona E., Foe, Ian, Loas, Andrei, Eaton, Dan L., Hao, Qi, Nile, Aaron H., Pentelute, Bradley L.
Publicado 2023