Quantitative Characterisation of Low Abundant Yeast Mitochondrial Proteins Reveals Compensation for Haplo-Insufficiency in Different Environments

por Manousaki, Alkisti, Bagnall, James, Spiller, David, Balarezo-Cisneros, Laura Natalia, White, Michael, Delneri, Daniela
Publicado 2022

Live-cell imaging reveals single-cell and population-level infection strategies of Listeria monocytogenes in macrophages

por Moran, Josephine, Feltham, Liam, Bagnall, James, Goldrick, Marie, Lord, Elizabeth, Nettleton, Catherine, Spiller, David G., Roberts, Ian, Paszek, Pawel
Publicado 2023

Heat shock response regulates stimulus-specificity and sensitivity of the pro-inflammatory NF-κB signalling

por Paszek, Anna, Kardyńska, Małgorzata, Bagnall, James, Śmieja, Jarosław, Spiller, David G., Widłak, Piotr, Kimmel, Marek, Widlak, Wieslawa, Paszek, Pawel
Publicado 2020

Post-transcriptional regulatory feedback encodes JAK-STAT signal memory of interferon stimulation

por Kalliara, Eirini, Kardynska, Malgorzata, Bagnall, James, Spiller, David G., Müller, Werner, Ruckerl, Dominik, Śmieja, Jarosław, Biswas, Subhra K., Paszek, Pawel
Publicado 2022

Gene-Specific Linear Trends Constrain Transcriptional Variability of the Toll-like Receptor Signaling

por Bagnall, James, Rowe, William, Alachkar, Nissrin, Roberts, James, England, Hazel, Clark, Christopher, Platt, Mark, Jackson, Dean A., Muldoon, Mark, Paszek, Pawel
Publicado 2020

Tight Control of Hypoxia-inducible Factor-α Transient Dynamics Is Essential for Cell Survival in Hypoxia

por Bagnall, James, Leedale, Joseph, Taylor, Sarah E., Spiller, David G., White, Michael R. H., Sharkey, Kieran J., Bearon, Rachel N., Sée, Violaine
Publicado 2014

Overexpression of IκB⍺ modulates NF-κB activation of inflammatory target gene expression

por Downton, Polly, Bagnall, James S., England, Hazel, Spiller, David G., Humphreys, Neil E., Jackson, Dean A., Paszek, Pawel, White, Michael R. H., Adamson, Antony D.
Publicado 2023

Cryptochrome proteins regulate the circadian intracellular behavior and localization of PER2 in mouse suprachiasmatic nucleus neurons

por Smyllie, Nicola J., Bagnall, James, Koch, Alex A., Niranjan, Dhevahi, Polidarova, Lenka, Chesham, Johanna E., Chin, Jason W., Partch, Carrie L., Loudon, Andrew S. I., Hastings, Michael H.
Publicado 2022

Stochasticity in the miR-9/Hes1 oscillatory network can account for clonal heterogeneity in the timing of differentiation

por Phillips, Nick E, Manning, Cerys S, Pettini, Tom, Biga, Veronica, Marinopoulou, Elli, Stanley, Peter, Boyd, James, Bagnall, James, Paszek, Pawel, Spiller, David G, White, Michael RH, Goodfellow, Marc, Galla, Tobias, Rattray, Magnus, Papalopulu, Nancy
Publicado 2016

Signal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states

por Adamson, Antony, Boddington, Christopher, Downton, Polly, Rowe, William, Bagnall, James, Lam, Connie, Maya-Mendoza, Apolinar, Schmidt, Lorraine, Harper, Claire V., Spiller, David G., Rand, David A., Jackson, Dean A., White, Michael R. H., Paszek, Pawel
Publicado 2016

Quantification of protein abundance and interaction defines a mechanism for operation of the circadian clock

por Koch, Alex A, Bagnall, James S, Smyllie, Nicola J, Begley, Nicola, Adamson, Antony D, Fribourgh, Jennifer L, Spiller, David G, Meng, Qing-Jun, Partch, Carrie L, Strimmer, Korbinian, House, Thomas A, Hastings, Michael H, Loudon, Andrew SI
Publicado 2022

Integration of Kinase and Calcium Signaling at the Level of Chromatin Underlies Inducible Gene Activation in T Cells

por Brignall, Ruth, Cauchy, Pierre, Bevington, Sarah L., Gorman, Bethany, Pisco, Angela O., Bagnall, James, Boddington, Christopher, Rowe, William, England, Hazel, Rich, Kevin, Schmidt, Lorraine, Dyer, Nigel P., Travis, Mark A., Ott, Sascha, Jackson, Dean A., Cockerill, Peter N., Paszek, Pawel
Publicado 2017

Quantitative live imaging of Venus::BMAL1 in a mouse model reveals complex dynamics of the master circadian clock regulator

por Yang, Nan, Smyllie, Nicola J., Morris, Honor, Gonçalves, Cátia F., Dudek, Michal, Pathiranage, Dharshika R. J., Chesham, Johanna E., Adamson, Antony, Spiller, David G., Zindy, Egor, Bagnall, James, Humphreys, Neil, Hoyland, Judith, Loudon, Andrew S. I., Hastings, Michael H., Meng, Qing-Jun
Publicado 2020

The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia

por Kitchen, Gareth B., Cunningham, Peter S., Poolman, Toryn M., Iqbal, Mudassar, Maidstone, Robert, Baxter, Matthew, Bagnall, James, Begley, Nicola, Saer, Ben, Hussell, Tracy, Matthews, Laura C., Dockrell, David H., Durrington, Hannah J., Gibbs, Julie E., Blaikley, John F., Loudon, Andrew S., Ray, David W.
Publicado 2020

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models

por Daniels, Michael J. D., Rivers-Auty, Jack, Schilling, Tom, Spencer, Nicholas G., Watremez, William, Fasolino, Victoria, Booth, Sophie J., White, Claire S., Baldwin, Alex G., Freeman, Sally, Wong, Raymond, Latta, Clare, Yu, Shi, Jackson, Joshua, Fischer, Nicolas, Koziel, Violette, Pillot, Thierry, Bagnall, James, Allan, Stuart M., Paszek, Pawel, Galea, James, Harte, Michael K., Eder, Claudia, Lawrence, Catherine B., Brough, David
Publicado 2016

The circadian clock protein REVERBα inhibits pulmonary fibrosis development

por Cunningham, Peter S., Meijer, Peter, Nazgiewicz, Alicja, Anderson, Simon G., Borthwick, Lee A., Bagnall, James, Kitchen, Gareth B., Lodyga, Monika, Begley, Nicola, Venkateswaran, Rajamiyer V., Shah, Rajesh, Mercer, Paul F., Durrington, Hannah J., Henderson, Neil C., Piper-Hanley, Karen, Fisher, Andrew J., Chambers, Rachel C., Bechtold, David A., Gibbs, Julie E., Loudon, Andrew S., Rutter, Martin K., Hinz, Boris, Ray, David W., Blaikley, John F.
Publicado 2020