Probing the depths of cellular senescence

por Baker, Darren J., Sedivy, John M.
Publicado 2013

Insights from In Vivo Studies of Cellular Senescence

por Prieto, Luis I., Graves, Sara I., Baker, Darren J.
Publicado 2020

Oncogenic senescence: a multi-functional perspective

por Baker, Darren J., Alimirah, Fatouma, van Deursen, Jan M., Campisi, Judith, Hildesheim, Jeffrey
Publicado 2017

Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis

por Jeganathan, Karthik, Malureanu, Liviu, Baker, Darren J., Abraham, Susan C., van Deursen, Jan M.
Publicado 2007

Chemotherapy-induced cellular senescence suppresses progression of Notch-driven T-ALL

por Zhang, Ying, Gundelach, Justin, Lindquist, Lonnie D., Baker, Darren J., van Deursen, Jan, Bram, Richard J.
Publicado 2019

Early aging–associated phenotypes in Bub3/Rae1 haploinsufficient mice

por Baker, Darren J., Jeganathan, Karthik B., Malureanu, Liviu, Perez-Terzic, Carmen, Terzic, Andre, van Deursen, Jan M.A.
Publicado 2006

Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation

por Babu, J. Ramesh, Jeganathan, Karthik B., Baker, Darren J., Wu, Xiaosheng, Kang-Decker, Ningling, van Deursen, Jan M.
Publicado 2003

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

por Bussian, Tyler J., Aziz, Asef, Meyer, Charlton F., Swenson, Barbara L., van Deursen, Jan M., Baker, Darren J.
Publicado 2018

Reduced Life- and Healthspan in Mice Carrying a Mono-Allelic BubR1 MVA Mutation

por Wijshake, Tobias, Malureanu, Liviu A., Baker, Darren J., Jeganathan, Karthik B., van de Sluis, Bart, van Deursen, Jan M.
Publicado 2012

BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer

por Weaver, Robbyn L, Limzerwala, Jazeel F, Naylor, Ryan M, Jeganathan, Karthik B, Baker, Darren J, van Deursen, Jan M
Publicado 2016

The Spindle Assembly Checkpoint Is Required for Hematopoietic Progenitor Cell Engraftment

por Brown, Andreas, Pospiech, Johannes, Eiwen, Karina, Baker, Darren J., Moehrle, Bettina, Sakk, Vadim, Nattamai, Kalpana, Vogel, Mona, Grigoryan, Ani, Geiger, Hartmut
Publicado 2017

Senescent cells limit p53 activity via multiple mechanisms to remain viable

por Sturmlechner, Ines, Sine, Chance C., Jeganathan, Karthik B., Zhang, Cheng, Fierro Velasco, Raul O., Baker, Darren J., Li, Hu, van Deursen, Jan M.
Publicado 2022

Expansion of myeloid‐derived suppressor cells with aging in the bone marrow of mice through a NF‐κB‐dependent mechanism

por Flores, Rafael R., Clauson, Cheryl L., Cho, Joonseok, Lee, Byeong‐Chel, McGowan, Sara J., Baker, Darren J., Niedernhofer, Laura J., Robbins, Paul D.
Publicado 2017

Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis

por Malureanu, Liviu, Jeganathan, Karthik B., Jin, Fang, Baker, Darren J., van Ree, Janine H., Gullon, Oliver, Chen, Zheyan, Henley, John R., van Deursen, Jan M.
Publicado 2010

Spartan deficiency causes genomic instability and progeroid phenotypes

por Maskey, Reeja S., Kim, Myoung Shin, Baker, Darren J., Childs, Bennett, Malureanu, Liviu A., Jeganathan, Karthik B., Machida, Yuka, van Deursen, Jan M., Machida, Yuichi J.
Publicado 2014

Hyperphosphorylated PTEN exerts oncogenic properties

por van Ree, Janine H., Jeganathan, Karthik B., Fierro Velasco, Raul O., Zhang, Cheng, Can, Ismail, Hamada, Masakazu, Li, Hu, Baker, Darren J., van Deursen, Jan M.
Publicado 2023

Age‐related decline in BubR1 impairs adult hippocampal neurogenesis

por Yang, Zhongxi, Jun, Heechul, Choi, Chan‐II, Yoo, Ki Hyun, Cho, Chang Hoon, Hussaini, Syed Mohammed Qasim, Simmons, Ambrosia J., Kim, Seonhee, van Deursen, Jan M., Baker, Darren J., Jang, Mi‐Hyeon
Publicado 2017

The progeroid gene BubR1 regulates axon myelination and motor function

por Choi, Chan-Il, Yoo, Ki Hyun, Qasim Hussaini, Syed Mohammed, Tak Jeon, Byeong, Welby, John, Gan, Haiyun, Scarisbrick, Isobel A., Zhang, Zhiguo, Baker, Darren J., van Deursen, Jan M., Rodriguez, Moses, Jang, Mi-Hyeon
Publicado 2016

Circulating levels of monocyte chemoattractant protein‐1 as a potential measure of biological age in mice and frailty in humans

por Yousefzadeh, Matthew J., Schafer, Marissa J., Noren Hooten, Nicole, Atkinson, Elizabeth J., Evans, Michele K., Baker, Darren J., Quarles, Ellen K., Robbins, Paul D., Ladiges, Warren C., LeBrasseur, Nathan K., Niedernhofer, Laura J.
Publicado 2017

Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan

por Baker, Darren J., Childs, Bennett G., Durik, Matej, Wijers, Melinde E., Sieben, Cynthia J., Zhong, Jian, Saltness, Rachel, Jeganathan, Karthik B., Versoza, Grace C., Pezeshki, Abdul-Mohammad, Khazaie, Khashayarsha, Miller, Jordan D., van Deursen, Jan M.
Publicado 2016